Madison A. Youngblom
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View article: Contingencies in biofilm adaptation of<i>Mycobacterium tuberculosis</i>
Contingencies in biofilm adaptation of<i>Mycobacterium tuberculosis</i> Open
Biofilms are structured microbial communities that offer protection from a range of environmental stressors. Studies of experimental evolution within biofilms have yielded important insights into mechanisms of biofilm formation, as well as…
View article: Erratum for Joyce et al., “Comparative Genomics of <i>Streptococcus oralis</i> Identifies Large Scale Homologous Recombination and a Genetic Variant Associated with Infection”
Erratum for Joyce et al., “Comparative Genomics of <i>Streptococcus oralis</i> Identifies Large Scale Homologous Recombination and a Genetic Variant Associated with Infection” Open
View article: Adaptation of the Mycobacterium tuberculosis transcriptome to biofilm growth
Adaptation of the Mycobacterium tuberculosis transcriptome to biofilm growth Open
Mycobacterium tuberculosis ( M . tb ), the causative agent of tuberculosis (TB), is a leading global cause of death from infectious disease. Biofilms are increasingly recognized as a relevant growth form during M . tb infection and may imp…
View article: Portrait of a generalist bacterium: pathoadaptation, metabolic specialization and extreme environments shape diversity of<i>Staphylococcus saprophyticus</i>
Portrait of a generalist bacterium: pathoadaptation, metabolic specialization and extreme environments shape diversity of<i>Staphylococcus saprophyticus</i> Open
Staphylococcus saprophyticus is a Gram-positive, coagulase-negative staphylococcus found in diverse environments including soil and freshwater, meat, and dairy foods. S. saprophyticus is also an important cause of urinary tract infections …
View article: Adaptation of the<i>Mycobacterium tuberculosis</i>transcriptome to biofilm growth
Adaptation of the<i>Mycobacterium tuberculosis</i>transcriptome to biofilm growth Open
Mycobacterium tuberculosis ( M. tb ), the causative agent of tuberculosis (TB), is a leading global cause of death from infectious disease. Biofilms are increasingly recognized as a relevant growth form during M. tb infection and may imped…
View article: Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile
Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile Open
Severe outbreaks and deaths have been linked to the emergence and global spread of fluoroquinolone-resistant Clostridioides difficile over the past two decades. At the same time, metronidazole, a nitro-containing antibiotic, has shown decr…
View article: The Gonococcal Genetic Island defines distinct sub-populations of Neisseria gonorrhoeae
The Gonococcal Genetic Island defines distinct sub-populations of Neisseria gonorrhoeae Open
The incidence of gonorrhoea is increasing at an alarming pace, and therapeutic options continue to narrow as a result of worsening drug resistance. Neisseria gonorrhoeae is naturally competent, allowing the organism to adapt rapidly to sel…
View article: Comparative Genomics of Streptococcus oralis Identifies Large Scale Homologous Recombination and a Genetic Variant Associated with Infection
Comparative Genomics of Streptococcus oralis Identifies Large Scale Homologous Recombination and a Genetic Variant Associated with Infection Open
The viridians group streptococci (VGS) are a large collection of closely related commensal streptococci, with many being opportunistic pathogens causing invasive diseases, such as bacteremia and infective endocarditis. Little is known abou…
View article: Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant <i>Clostridioides difficile</i>
Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant <i>Clostridioides difficile</i> Open
Severe outbreaks and deaths have been linked to the emergence and global spread of fluoroquinolone-resistant Clostridioides difficile over the past two decades. At the same time, metronidazole, a nitro-containing antibiotic, has shown decr…
View article: Comparative genomics of<i>Streptococcus oralis</i>identifies large scale homologous recombination and a genetic variant associated with infection
Comparative genomics of<i>Streptococcus oralis</i>identifies large scale homologous recombination and a genetic variant associated with infection Open
The viridans group streptococci (VGS) are a large consortium of commensal streptococci that colonize the human body. Many species within this group are opportunistic pathogens causing bacteremia and infective endocarditis (IE), yet little …
View article: Rapid adaptation of a complex trait during experimental evolution of Mycobacterium tuberculosis
Rapid adaptation of a complex trait during experimental evolution of Mycobacterium tuberculosis Open
Tuberculosis (TB), caused by Mycobacterium tuberculosis ( M. tb ), is a leading cause of death due to infectious disease. TB is not traditionally associated with biofilms, but M. tb biofilms are linked with drug and immune tolerance and th…
View article: Author response: Rapid adaptation of a complex trait during experimental evolution of Mycobacterium tuberculosis
Author response: Rapid adaptation of a complex trait during experimental evolution of Mycobacterium tuberculosis Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Tuberculo…
View article: Genome reorganization during emergence of host-associated Mycobacterium abscessus
Genome reorganization during emergence of host-associated Mycobacterium abscessus Open
Mycobacterium abscessus is a rapid growing, free-living species of bacterium that also causes lung infections in humans. Human infections are usually acquired from the environment; however, dominant circulating clones (DCCs) have emerged r…
View article: Rapid adaptation of a complex trait during experimental evolution of <i>Mycobacterium tuberculosis</i>
Rapid adaptation of a complex trait during experimental evolution of <i>Mycobacterium tuberculosis</i> Open
Tuberculosis (TB), caused by Mycobacterium tuberculosis ( M. tb ), is a leading cause of death due to infectious disease. TB is not traditionally associated with biofilms, but M. tb biofilms are linked with drug and immune tolerance and th…
View article: Bacterial communities of herbivores and pollinators that have co-evolved <i>Cucurbita</i> spp
Bacterial communities of herbivores and pollinators that have co-evolved <i>Cucurbita</i> spp Open
Insects, like all animals, are exposed to diverse environmental microbes throughout their life cycle. Yet, we know little about variation in the microbial communities associated with the majority of wild, unmanaged insect species. Here, we…