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View article: Enolase inhibitors as therapeutic leads for Naegleria fowleri infection
Enolase inhibitors as therapeutic leads for Naegleria fowleri infection Open
Infections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amoebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking an…
Crystal structure and biophysical characterization of IspD from <i>Burkholderia thailandensis</i> and <i>Mycobacterium paratuberculosis</i> Open
The methylerythritol phosphate (MEP) pathway is a metabolic pathway that produces the isoprenoids isopentyl pyrophosphate and dimethylallyl pyrophosphate. Notably, the MEP pathway is present in bacteria and not in mammals, which makes the …
View article: Enolase inhibitors as therapeutic leads for <i>Naegleria fowleri</i> infection
Enolase inhibitors as therapeutic leads for <i>Naegleria fowleri</i> infection Open
Infections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking and…
Structure-Guided Discovery of N<sup>5</sup>-CAIR Mutase Inhibitors Open
Because purine nucleotides are essential for all life, differences between how microbes and humans metabolize purines can be exploited for the development of antimicrobial therapies. While humans biosynthesize purine nucleotides in a 10-st…
Bacterial structural genomics target enabled by a recently discovered potent fungal acetyl-CoA synthetase inhibitor Open
The compound ethyl-adenosyl monophosphate ester (ethyl-AMP) has been shown to effectively inhibit acetyl-CoA synthetase (ACS) enzymes and to facilitate the crystallization of fungal ACS enzymes in various contexts. In this study, the addit…
View article: Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography
Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography Open
E-cadherin adhesion is regulated at the cell surface, a process that can be replicated by activating antibodies. We use cryo-electron microscopy (EM) and X-ray crystallography to examine functional states of the cadherin adhesive dimer. Th…
Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1 Open
We describe the identification and characterization of a series of covalent inhibitors of the C-terminal kinase domain (CTKD) of MSK1. The initial hit was identified via a high-throughput screening and represents a rare example of a covale…
View article: Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography
Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography Open
E-cadherin adhesion is regulated at the cell surface, a process that can be replicated by activating antibodies. We use cryo-EM and X-ray crystallography to examine functional states of the cadherin adhesive dimer. This dimer is mediated b…
Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba Open
Naegleria fowleri is a pathogenic, thermophilic, free-living amoeba which causes primary amebic meningoencephalitis (PAM). Penetrating the olfactory mucosa, the brain-eating amoeba travels along the olfactory nerves, burrowing through the …
<i>Naegleria fowleri:</i> protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba Open
Naegleria fowleri is a pathogenic, thermophilic, free-living amoeba which causes primary amebic meningoencephalitis (PAM). Penetrating the olfactory mucosa, the brain-eating amoeba travels along the olfactory nerves, burrowing through the …
View article: HGT in the human and skin commensal <i>Malassezia</i> : A bacterially derived flavohemoglobin is required for NO resistance and host interaction
HGT in the human and skin commensal <i>Malassezia</i> : A bacterially derived flavohemoglobin is required for NO resistance and host interaction Open
Significance Malassezia species are the main fungal components of the mammalian skin microbiome and are associated with a number of skin disorders. Recently, Malassezia has also been found in association with Crohn’s disease and with pancr…
Horizontal gene transfer in the human and skin commensal <i>Malassezia</i> : a bacterially-derived flavohemoglobin is required for NO resistance and host interaction Open
The skin of humans and animals is colonized by commensal and pathogenic fungi and bacteria that share this ecological niche and have established microbial interactions. Malassezia are the most abundant fungal skin inhabitant of warm-bloode…