Madison L. Lotstein
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View article: Single-cell spatial transcriptomics of fixed, paraffin-embedded biopsies reveals colitis-associated cell networks
Single-cell spatial transcriptomics of fixed, paraffin-embedded biopsies reveals colitis-associated cell networks Open
Background & Aims Imaging-based, single-cell spatial transcriptomics (iSCST) using formalin-fixed, paraffin-embedded (FFPE) tissue could transform translational research by retaining all tissue cell subsets and spatial locations while enab…
View article: Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis
Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis Open
View article: Single-Cell Spatial Transcriptomics of Fixed, Paraffin-Embedded Biopsies Reveals Colitis-Associated Cell Networks
Single-Cell Spatial Transcriptomics of Fixed, Paraffin-Embedded Biopsies Reveals Colitis-Associated Cell Networks Open
View article: Chronic social defeat alters brain vascular-associated cell gene expression patterns leading to vascular dysfunction and immune system activation
Chronic social defeat alters brain vascular-associated cell gene expression patterns leading to vascular dysfunction and immune system activation Open
View article: Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis
Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis Open
Ulcerative colitis (UC) is driven by immune and stromal subsets, culminating in epithelial injury. Vedolizumab (VDZ) is an anti-integrin antibody that is effective for treating UC. VDZ is known to inhibit lymphocyte trafficking to the inte…
View article: CCR2 monocytes repair cerebrovascular damage caused by chronic social defeat stress
CCR2 monocytes repair cerebrovascular damage caused by chronic social defeat stress Open
Immune surveillance of the brain plays an important role in health and disease. Peripheral leukocytes patrol blood-brain barrier interfaces, and after injury, monocytes cross the cerebrovasculature and follow a pattern of pro- and anti-inf…