Madison Miller
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View article: How medical students' trauma histories affect their clinical clerkship experiences
How medical students' trauma histories affect their clinical clerkship experiences Open
Background As the gender demographics of medical students have evolved over the past decades, it is important to understand potential stressors and challenges that may affect clinical learning experiences. This study investigated the preva…
View article: Template switching between the leading and lagging strands at replication forks generates inverted copy number variants through hairpin-capped extrachromosomal DNA
Template switching between the leading and lagging strands at replication forks generates inverted copy number variants through hairpin-capped extrachromosomal DNA Open
Inherited and germ-line de novo copy number variants (CNVs) are increasingly found to be correlated with human developmental and cancerous phenotypes. Several models for template switching during replication have been proposed to explain t…
View article: Template switching between the leading and lagging strands at replication forks generates inverted copy number variants through hairpin-capped extrachromosomal DNA
Template switching between the leading and lagging strands at replication forks generates inverted copy number variants through hairpin-capped extrachromosomal DNA Open
Inherited and de novo copy number variants (CNVs) are increasingly found to be correlated with human developmental and cancerous phenotypes. Several models for template switching during replication have been proposed to explain the generat…
View article: Ribosomal DNA replication time coordinates completion of genome replication and anaphase in yeast
Ribosomal DNA replication time coordinates completion of genome replication and anaphase in yeast Open
Timely completion of genome replication is a prerequisite for mitosis, genome integrity, and cell survival. A challenge to this timely completion comes from the need to replicate the hundreds of untranscribed copies of rDNA that organisms …
View article: Evaluation of a microperforate hymen leading to the incidental diagnosis of a borderline ovarian tumour
Evaluation of a microperforate hymen leading to the incidental diagnosis of a borderline ovarian tumour Open
Microperforate hymens are rare anatomical variants with an unknown incidence and very few reported cases. Borderline ovarian tumours are similarly uncommon, with an incidence of approximately 0.002%–0.006%. The concurrent presence of a mic…
View article: Exploring Soundscapes, Ambience and Photography through the Creative Process of Alternate Reality Café
Exploring Soundscapes, Ambience and Photography through the Creative Process of Alternate Reality Café Open
Electronic music is growing in experimentation and exploration, especially with the popularity of social media and music production applications.Two subgenres of electronic music which have evolved along with technological advancement are …
View article: An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression
An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression Open
Despite current advancements in research and therapeutics, lung cancer remains the leading cause of cancer-related mortality worldwide. This is mainly due to the resistance that patients develop against chemotherapeutic agents over the cou…
View article: Author response: An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression
Author response: An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Despite current advancements in research a…
View article: An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKI resistant cells by modulating miR-335 expression
An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKI resistant cells by modulating miR-335 expression Open
Lung cancer remains the leading cause of cancer-related mortality worldwide, despite current advancements in research and therapeutics. Many patients diagnosed with lung cancer will develop resistance to chemotherapeutic agents. In the con…
View article: Opioid Use Disorders in People Living with HIV/AIDS: A Review of Implications for Patient Outcomes, Drug Interactions, and Neurocognitive Disorders
Opioid Use Disorders in People Living with HIV/AIDS: A Review of Implications for Patient Outcomes, Drug Interactions, and Neurocognitive Disorders Open
The opioid epidemic has had a significant, negative impact in the United States, and people living with HIV/AIDS (PLWHA) represent a vulnerable sub-population that is at risk for negative sequela from prolonged opioid use or opioid use dis…
View article: TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions
TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions Open
TP53 truncating mutations are common in human tumors and are thought to give rise to p53-null alleles. Here, we show that TP53 exon-6 truncating mutations occur at higher than expected frequencies and produce proteins that lack canonical p…
View article: Author response: TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions
Author response: TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions Open
Full text Figures and data Side by side Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract TP53 truncating mutations a…
View article: The Evolution of <i>TP53</i> Mutations: From Loss-of-Function to Separation-of-Function Mutants.
The Evolution of <i>TP53</i> Mutations: From Loss-of-Function to Separation-of-Function Mutants. Open
As the most mutated gene in cancer, it is no surprise that TP53 has been the center of cancer biology discourse since its discovery in the late 1970s. Although early demonstrations of p53's role in the modulation of cell proliferation and …