Madison R. Glass
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View article: Excitatory cortical neurons from CDKL5 deficiency disorder patient-derived organoids show early hyperexcitability not identified in neurogenin2 induced neurons
Excitatory cortical neurons from CDKL5 deficiency disorder patient-derived organoids show early hyperexcitability not identified in neurogenin2 induced neurons Open
View article: Early cell cycle genes in cortical organoid progenitors predict interindividual variability in infant brain growth trajectories
Early cell cycle genes in cortical organoid progenitors predict interindividual variability in infant brain growth trajectories Open
Summary Human induced pluripotent stem cell (iPSC) derived cortical organoids (hCOs) model neurogenesis on an individual’s genetic background. The degree to which hCO phenotypes recapitulate the brain growth of the participants from which …
View article: Excitatory Cortical Neurons from CDKL5 Deficiency Disorder Patient-Derived Organoids Show Early Hyperexcitability Not Identified in Neurogenin2 Induced Neurons
Excitatory Cortical Neurons from CDKL5 Deficiency Disorder Patient-Derived Organoids Show Early Hyperexcitability Not Identified in Neurogenin2 Induced Neurons Open
CDKL5 deficiency disorder (CDD) is a rare developmental and epileptic encephalopathy resulting from variants in cyclin-dependent kinase-like 5 (CDKL5) that lead to impaired kinase activity or loss of function. CDD is one of the most common…
View article: Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architecture
Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architecture Open
While guided human cortical organoid (hCO) protocols reproducibly generate cortical cell types at one site, variability in hCO phenotypes across sites using a harmonized protocol has not yet been evaluated. To determine the cross-site repr…
View article: Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architecture
Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architecture Open
Background: Reproducibility of human cortical organoid (hCO) phenotypes remains a concern for modeling neurodevelopmental disorders. While guided hCO protocols reproducibly generate cortical cell types in multiple cell lines at one site, v…
View article: Donor perspectives on informed consent and use of biospecimens for brain organoid research
Donor perspectives on informed consent and use of biospecimens for brain organoid research Open
View article: Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice
Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice Open
Angelman syndrome (AS) is a neurodevelopmental disorder characterized by intellectual disability, lack of speech, ataxia, EEG abnormalities, and epilepsy. Seizures in individuals with AS are common, debilitating, and often drug resistant. …
View article: Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice
Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice Open
Angelman syndrome (AS) is a neurodevelopmental disorder characterized by intellectual disability, lack of speech, ataxia, EEG abnormalities, and epilepsy. Seizures in AS individuals are often refractory to existing antiepileptic medication…