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View article: Multi-omics analysis highlights the link of aging-related cognitive decline with systemic inflammation and alterations of tissue-maintenance
Multi-omics analysis highlights the link of aging-related cognitive decline with systemic inflammation and alterations of tissue-maintenance Open
Aging-related cognitive decline is associated with changes across different tissues and the gut microbiome, including dysfunction of the gut-brain axis. However, only few studies have linked multi-organ alterations to cognitive decline dur…
View article: The chloride cotransporter NKCC1 regulates self-renewal of hippocampal neural stem cells via the transcription factor Sox11
The chloride cotransporter NKCC1 regulates self-renewal of hippocampal neural stem cells via the transcription factor Sox11 Open
Summary The GABAergic-mediated depolarization plays a key role in controlling stem cell fate and neurogenesis within the dentate gyrus of the hippocampal formation. This depolarization effect is highly dependent on the balance between the …
View article: Metabolic modelling reveals the aging-associated decline of host–microbiome metabolic interactions in mice
Metabolic modelling reveals the aging-associated decline of host–microbiome metabolic interactions in mice Open
Aging is accompanied by considerable changes in the gut microbiome, yet the molecular mechanisms driving aging and the role of the microbiome remain unclear. Here we combined metagenomics, transcriptomics and metabolomics from aging mice w…
View article: Nonlinear DNA methylation trajectories in aging male mice
Nonlinear DNA methylation trajectories in aging male mice Open
View article: Restoring Age-Related Cognitive Decline through Environmental Enrichment: A Transcriptomic Approach
Restoring Age-Related Cognitive Decline through Environmental Enrichment: A Transcriptomic Approach Open
Cognitive decline is one of the greatest health threats of old age and the maintenance of optimal brain function across a lifespan remains a big challenge. The hippocampus is considered particularly vulnerable but there is cross-species co…