Mads U. Werner
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View article: Persistent severe pain following groin hernia repair: Somatosensory profiles, pain trajectories, and clinical outcomes – Synopsis of a PhD thesis
Persistent severe pain following groin hernia repair: Somatosensory profiles, pain trajectories, and clinical outcomes – Synopsis of a PhD thesis Open
Background Persistent severe intensity pain after groin hernia repair (PSPG; 200–400/10,000 repairs) is a significant surgical complication impacting the activity of daily living (ADL) and psychosocial functioning. This PhD synopsis presen…
View article: Stellate ganglion block for mental disorders – too good to be true?
Stellate ganglion block for mental disorders – too good to be true? Open
View article: Quantitative sensory testing – <i>Quo Vadis</i> ?
Quantitative sensory testing – <i>Quo Vadis</i> ? Open
View article: Abstracts presented at SASP 2025, Reykjavik, Iceland. From the Test Tube to the Clinic – Applying the Science
Abstracts presented at SASP 2025, Reykjavik, Iceland. From the Test Tube to the Clinic – Applying the Science Open
View article: P023 Detection of intra-tumoral heterogeneity in histological Prostate-Specific Membrane Antigen (PSMA) expression of primary Prostate Cancer (PCa) with [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 Positrone Emission Tomography (PET) in comparison
P023 Detection of intra-tumoral heterogeneity in histological Prostate-Specific Membrane Antigen (PSMA) expression of primary Prostate Cancer (PCa) with [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 Positrone Emission Tomography (PET) in comparison Open
View article: The relationship between preoperative sleep disturbance and acute postoperative pain control: A systematic review and meta-analysis
The relationship between preoperative sleep disturbance and acute postoperative pain control: A systematic review and meta-analysis Open
Poor preoperative sleep quality and impaired sleep continuity may heighten acute postoperative pain intensity and increase analgesic consumption, with negative implications for recovery, mental and physical health. The main objective of th…
View article: Assessment of somatosensory profiles by quantitative sensory testing in children and adolescents with and without cerebral palsy and chronic pain
Assessment of somatosensory profiles by quantitative sensory testing in children and adolescents with and without cerebral palsy and chronic pain Open
In CCP, the SSPs were independent of pain status and findings on MR images. In all CCP the SSPs resembled TDC with chronic pain, compared to TDC without chronic pain. This suggests that CCP do not have the normal neuroplastic adaptive proc…
View article: Population pharmacokinetic–pharmacodynamic model of subcutaneous bupivacaine in a novel extended‐release microparticle formulation
Population pharmacokinetic–pharmacodynamic model of subcutaneous bupivacaine in a novel extended‐release microparticle formulation Open
The objective of this study was to develop a population pharmacokinetic–pharmacodynamic model of subcutaneously administered bupivacaine in a novel extended‐release microparticle formulation for postoperative pain management. Bupivacaine w…
View article: Dose safety and pharmacodynamics of subcutaneous bupivacaine in a novel extended‐release microparticle formulation: A phase 1, dose‐ascending study in male volunteers
Dose safety and pharmacodynamics of subcutaneous bupivacaine in a novel extended‐release microparticle formulation: A phase 1, dose‐ascending study in male volunteers Open
A novel microparticle‐based extended‐release local anaesthetic containing a bupivacaine/poly‐lactic‐co‐glycolic acid (PLGA; LIQ865A) or plain bupivacaine (LIQ865B) was examined in a first‐in‐human trial. The objectives were to examine the …
View article: Quantitative somatosensory assessments in patients with persistent pain following groin hernia repair: A systematic review with a meta-analytical approach
Quantitative somatosensory assessments in patients with persistent pain following groin hernia repair: A systematic review with a meta-analytical approach Open
Objectives Quantitative sensory testing (QST) provides an assessment of cutaneous and deep tissue sensitivity and pain perception under normal and pathological settings. Approximately 2–4% of individuals undergoing groin hernia repair (GHR…
View article: Christmas greetings 2024 from the Editor-in-Chief
Christmas greetings 2024 from the Editor-in-Chief Open
View article: Low-dose naltrexone for treatment of pain in patients with fibromyalgia: a randomized, double-blind, placebo-controlled, crossover study
Low-dose naltrexone for treatment of pain in patients with fibromyalgia: a randomized, double-blind, placebo-controlled, crossover study Open
Introduction: Fibromyalgia (FM) is a chronic fluctuating, nociplastic pain condition. Naltrexone is a µ-opioid-receptor antagonist; preliminary studies have indicated a pain-relieving effect of low-dose naltrexone (LDN) in patients with FM…
View article: Somatosensory Outcomes Following Re-Surgery in Persistent Severe Pain After Groin Hernia Repair: A Prospective Observational Study
Somatosensory Outcomes Following Re-Surgery in Persistent Severe Pain After Groin Hernia Repair: A Prospective Observational Study Open
In this subset of patients with PSPG who underwent re-surgery, the procedure was associated with improved pain and functional outcomes. While the increase in somatosensory detection thresholds mirrors the surgery-induced cutaneous deaffere…
View article: Analgesic efficacy of sleep-promoting pharmacotherapy in patients with chronic pain: a systematic review and meta-analysis
Analgesic efficacy of sleep-promoting pharmacotherapy in patients with chronic pain: a systematic review and meta-analysis Open
Dysregulation of sleep heightens pain sensitivity and may contribute to pain chronification. Interventions which consolidate and lengthen sleep have the potential to improve pain control. The main objective of this systematic review was to…
View article: Detailed statistical analysis plan for the neurological complications in endoscopic versus open radial artery harvest (NEO) randomised clinical trial
Detailed statistical analysis plan for the neurological complications in endoscopic versus open radial artery harvest (NEO) randomised clinical trial Open
View article: Abstract for the special issue
Abstract for the special issue Open
Reviews (Topical, Systematic, or Meta-analysis
View article: The Harald Breivik lecture 2022. Pathophysiology in persistent severe pain after groin hernia repair
The Harald Breivik lecture 2022. Pathophysiology in persistent severe pain after groin hernia repair Open
The transition from a healthy to a persistent severe pain state following otherwise successful elective surgery is a feared complication. Groin hernia repair, previously considered minor surgery, is a standard surgical procedure annually p…
View article: The Scandinavian Society for the Study of Pain 2022 Postgraduate Course and Annual Scientific (SASP 2022) Meeting 12th to 14th October at Rigshospitalet, Copenhagen
The Scandinavian Society for the Study of Pain 2022 Postgraduate Course and Annual Scientific (SASP 2022) Meeting 12th to 14th October at Rigshospitalet, Copenhagen Open
Article The Scandinavian Society for the Study of Pain 2022 Postgraduate Course and Annual Scientific (SASP 2022) Meeting 12th to 14th October at Rigshospitalet, Copenhagen was published on August 9, 2022 in the journal Scandinavian Journa…
View article: Detailed statistical analysis plan for the Neurological complications in Endoscopic versus Open radial artery harvest (NEO) randomised clinical trial
Detailed statistical analysis plan for the Neurological complications in Endoscopic versus Open radial artery harvest (NEO) randomised clinical trial Open
IntroductionCoronary artery bypass grafting can be conducted using the radial artery as a bypass graft. However, it remains unclear, which harvesting method is superior, i.e. endoscopic or open radial artery, and which site for proximal an…
View article: When surgery prompts discontinuation of opioids
When surgery prompts discontinuation of opioids Open
View article: Methodology and applicability of the human contact burn injury model: A systematic review
Methodology and applicability of the human contact burn injury model: A systematic review Open
The contact burn injury model is an experimental contact thermode-based physiological pain model primarily applied in research of drug efficacy in humans. The employment of the contact burn injury model across studies has been inconsistent…
View article: Risk for persistent post-delivery pain – increased by pre-pregnancy pain and depression. Similar to persistent post-surgical pain in general?
Risk for persistent post-delivery pain – increased by pre-pregnancy pain and depression. Similar to persistent post-surgical pain in general? Open
Article Risk for persistent post-delivery pain – increased by pre-pregnancy pain and depression. Similar to persistent post-surgical pain in general? was published on April 1, 2021 in the journal Scandinavian Journal of Pain (volume 21, is…
View article: High-dose naloxone: Effects by late administration on pain and hyperalgesia following a human heat injury model. A randomized, double-blind, placebo-controlled, crossover trial with an enriched enrollment design
High-dose naloxone: Effects by late administration on pain and hyperalgesia following a human heat injury model. A randomized, double-blind, placebo-controlled, crossover trial with an enriched enrollment design Open
Severe chronic postsurgical pain has a prevalence of 4–10% in the surgical population. The underlying nociceptive mechanisms have not been well characterized. Following the late resolution phase of an inflammatory injury, high-dose μ-opioi…
View article: Trajectories in severe persistent pain after groin hernia repair: a retrospective analysis
Trajectories in severe persistent pain after groin hernia repair: a retrospective analysis Open
Objectives Severe persistent post-surgical pain (PPSP) remains a significant healthcare problem. In the third most common surgical procedure in the U.K., groin hernia repair, including 85,000 surgeries, estimated 1,500–3,000 patients will …
View article: Neuroplasticity induced by general anaesthesia: study protocol for a randomised cross-over clinical trial exploring the effects of sevoflurane and propofol on the brain – A 3-T magnetic resonance imaging study of healthy volunteers
Neuroplasticity induced by general anaesthesia: study protocol for a randomised cross-over clinical trial exploring the effects of sevoflurane and propofol on the brain – A 3-T magnetic resonance imaging study of healthy volunteers Open
View article: Change in Editorship: A Tribute to the Outgoing Editor-in-Chief
Change in Editorship: A Tribute to the Outgoing Editor-in-Chief Open
the College of Anaesthetists of Ireland, and the Faculty of Pain Medicine of the College of Anaesthetists of Ireland.Harald Breivik is Knight of 1st Class of the Royal Norwegian Order of St. Olav.Harald Breivik has published more than 400 …
View article: A national center for persistent severe pain after groin hernia repair
A national center for persistent severe pain after groin hernia repair Open
Severe persistent pain after groin hernia repair impairs quality-of-life. Prospective, consecutive cohort study including patients with pain-related impairment of physical and social life. Relevant surgical records were obtained, and exami…
View article: <p>A single session of hyperbaric oxygen therapy demonstrates acute and long-lasting neuroplasticity effects in humans: a replicated, randomized controlled clinical trial</p>
A single session of hyperbaric oxygen therapy demonstrates acute and long-lasting neuroplasticity effects in humans: a replicated, randomized controlled clinical trial Open
Our data demonstrate that a single HBOT-session compared to control is associated with both acute and long-lasting mitigating effects on BI-induced SHA, confirming central anti-inflammatory, neuroplasticity effects of hyperbaric oxygen the…
View article: High-dose naloxone, an experimental tool uncovering latent sensitisation: pharmacokinetics in humans
High-dose naloxone, an experimental tool uncovering latent sensitisation: pharmacokinetics in humans Open
View article: EP-1597: Focal dose escalation in prostate cancer with PSMA-PET/CT and MRI: planning study based on histology
EP-1597: Focal dose escalation in prostate cancer with PSMA-PET/CT and MRI: planning study based on histology Open