Magali Grange
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View article: 879 Deep immunoprofiling of tumor mouse models for preclinical studies
879 Deep immunoprofiling of tumor mouse models for preclinical studies Open
View article: SMAC mimetic drives microglia phenotype and glioblastoma immune microenvironment
SMAC mimetic drives microglia phenotype and glioblastoma immune microenvironment Open
Tumor-associated macrophages/microglia (TAMs) are highly plastic and heterogeneous immune cells that can be immune-supportive or tumor-supportive depending of the microenvironment. TAMs are the most abundant immune cells in glioblastoma (G…
View article: Antiviral activity of intracellular nanobodies targeting the influenza virus RNA-polymerase core
Antiviral activity of intracellular nanobodies targeting the influenza virus RNA-polymerase core Open
Influenza viruses transcribe and replicate their genome in the nucleus of the infected cells, two functions that are supported by the viral RNA-dependent RNA-polymerase (FluPol). FluPol displays structural flexibility related to distinct f…
View article: SMAC mimetics drive microglia phenotype and glioblastoma immune microenvironment
SMAC mimetics drive microglia phenotype and glioblastoma immune microenvironment Open
Background Tumor-associated macrophages/microglia (TAMs) are highly plastic and heterogeneous immune cells that can be immune-supportive or tumor-supportive depending on the microenvironment. TAMs are the most abundant immune cells in glio…
View article: A novel mass cytometry protocol optimized for immunophenotyping of low-frequency antigen-specific T cells
A novel mass cytometry protocol optimized for immunophenotyping of low-frequency antigen-specific T cells Open
Understanding antigen-specific T-cell responses, for example, following virus infections or allergen exposure, is of high relevance for the development of vaccines and therapeutics. We aimed on optimizing immunophenotyping of T cells after…
View article: Melanoma-inhibitor of apoptosis protein: a key driver of microglia phenotype and glioblastoma immune microenvironment
Melanoma-inhibitor of apoptosis protein: a key driver of microglia phenotype and glioblastoma immune microenvironment Open
Tumor-associated macrophages/microglia (TAMs) are highly plastic and heterogeneous immune cells that can be immune-supportive or tumor-supportive depending of the microenvironment. TAMs are the most abundant immune cells in glioblastoma (G…
View article: Antiviral activity of intracellular nanobodies targeting the influenza virus RNA-polymerase core
Antiviral activity of intracellular nanobodies targeting the influenza virus RNA-polymerase core Open
Influenza viruses transcribe and replicate their genome in the nucleus of the infected cells, two functions that are supported by the viral RNA-dependent RNA-polymerase (FluPol). FluPol displays structural flexibility related to distinct f…
View article: Data from Activated STAT5 Promotes Long-Lived Cytotoxic CD8<sup>+</sup> T Cells That Induce Regression of Autochthonous Melanoma
Data from Activated STAT5 Promotes Long-Lived Cytotoxic CD8<sup>+</sup> T Cells That Induce Regression of Autochthonous Melanoma Open
Immunotherapy based on adoptive transfer of tumor antigen-specific CD8+ T cell (TC) is generally limited by poor in vivo expansion and tumor infiltration. In this study, we report that activated STAT5 transcription factor…
View article: Data from Activated STAT5 Promotes Long-Lived Cytotoxic CD8<sup>+</sup> T Cells That Induce Regression of Autochthonous Melanoma
Data from Activated STAT5 Promotes Long-Lived Cytotoxic CD8<sup>+</sup> T Cells That Induce Regression of Autochthonous Melanoma Open
Immunotherapy based on adoptive transfer of tumor antigen-specific CD8+ T cell (TC) is generally limited by poor in vivo expansion and tumor infiltration. In this study, we report that activated STAT5 transcription factor…
View article: Supplementary Methods, Figures 1-6 from Activated STAT5 Promotes Long-Lived Cytotoxic CD8<sup>+</sup> T Cells That Induce Regression of Autochthonous Melanoma
Supplementary Methods, Figures 1-6 from Activated STAT5 Promotes Long-Lived Cytotoxic CD8<sup>+</sup> T Cells That Induce Regression of Autochthonous Melanoma Open
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View article: Supplementary Methods, Figures 1-6 from Activated STAT5 Promotes Long-Lived Cytotoxic CD8<sup>+</sup> T Cells That Induce Regression of Autochthonous Melanoma
Supplementary Methods, Figures 1-6 from Activated STAT5 Promotes Long-Lived Cytotoxic CD8<sup>+</sup> T Cells That Induce Regression of Autochthonous Melanoma Open
PDF file - 1.1MB
View article: Extracellular vesicles as a platform to study cell-surface membrane proteins
Extracellular vesicles as a platform to study cell-surface membrane proteins Open
View article: Control of <scp>CD</scp>8 T cell proliferation and terminal differentiation by active <scp>STAT</scp>5 and <scp>CDKN</scp>2A/<scp>CDKN</scp>2B
Control of <span>CD</span>8 T cell proliferation and terminal differentiation by active <span>STAT</span>5 and <span>CDKN</span>2A/<span>CDKN</span>2B Open
Summary CD 8 T cells used in adoptive immunotherapy may be manipulated to optimize their effector functions, tissue‐migratory properties and long‐term replicative potential. We reported that antigen‐stimulated CD 8 T cells transduced to ex…
View article: IFNγ producing CD8<sup>+</sup>T cells modified to resist major immune checkpoints induce regression of MHC class I-deficient melanomas
IFNγ producing CD8<sup>+</sup>T cells modified to resist major immune checkpoints induce regression of MHC class I-deficient melanomas Open
Tumors with reduced expression of MHC class I (MHC-I) molecules may be unrecognized by tumor antigen-specific CD8+ T cells and thus constitute a challenge for cancer immunotherapy. Here we monitored development of autochthonous …