Magdalena Otrocka
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View article: Morphological map of under- and overexpression of genes in human cells
Morphological map of under- and overexpression of genes in human cells Open
View article: Integrated transcriptomic and functional modeling reveals AKT and mTOR synergy in colorectal cancer
Integrated transcriptomic and functional modeling reveals AKT and mTOR synergy in colorectal cancer Open
View article: Targeting <scp>TUBG1</scp> in <scp>RB1</scp> ‐negative tumors
Targeting <span>TUBG1</span> in <span>RB1</span> ‐negative tumors Open
The disruption of microtubule dynamics serves as a pivotal strategy for eliminating tumor cells, despite its accompanying toxicities affecting non‐tumor cells. This study investigates the potential of selectively targeting γ‐tubulin1 (TUBG…
View article: Morphological map of under- and over-expression of genes in human cells
Morphological map of under- and over-expression of genes in human cells Open
Cell Painting images offer valuable insights into a cell’s state and enable many biological applications, but publicly available arrayed datasets only include hundreds of genes perturbed. The JUMP (Joint Undertaking in Morphological Profil…
View article: High-throughput neural stem cell-based drug screening identifies S6K1 inhibition as a selective vulnerability in sonic hedgehog-medulloblastoma
High-throughput neural stem cell-based drug screening identifies S6K1 inhibition as a selective vulnerability in sonic hedgehog-medulloblastoma Open
Background Medulloblastoma (MB) is one of the most common malignant brain tumors in children. Current treatments have increased overall survival but can lead to devastating side effects and late complications in survivors, emphasizing the …
View article: High-throughput neural stem cell-based drug screening identifies S6K1 inhibition as a selective vulnerability in SHH-medulloblastoma
High-throughput neural stem cell-based drug screening identifies S6K1 inhibition as a selective vulnerability in SHH-medulloblastoma Open
Background Medulloblastoma (MB) is one of the most common malignant brain tumors in children. Current treatments have increased overall survival but can lead to devastating side effects and late complications in survivors, emphasizing the …
View article: JUMP Cell Painting dataset: morphological impact of 136,000 chemical and genetic perturbations
JUMP Cell Painting dataset: morphological impact of 136,000 chemical and genetic perturbations Open
Image-based profiling has emerged as a powerful technology for various steps in basic biological and pharmaceutical discovery, but the community has lacked a large, public reference set of data from chemical and genetic perturbations. Here…
View article: Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries
Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries Open
Adenosine to inosine editing is common in the human transcriptome and changes of this essential activity is associated with disease. Children with ADAR1 mutations develop fatal Aicardi-Goutières syndrome characterized by aberrant interfero…
View article: A novel derivative of the fungal antimicrobial peptide plectasin is active against Mycobacterium tuberculosis
A novel derivative of the fungal antimicrobial peptide plectasin is active against Mycobacterium tuberculosis Open
View article: Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib
Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib Open
View article: Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration
Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration Open
We identify compounds that induce PGC-1α1 protein accumulation and show that this increases uncoupled respiration in brown adipocytes. This screening platform establishes the foundation for a new class of therapeutics with potential use in…