Magdalena Steiner
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View article: Targeting <scp>TGF</scp>‐β signaling, oxidative stress, and cellular senescence rescues osteoporosis in gerodermia osteodysplastica
Targeting <span>TGF</span>‐β signaling, oxidative stress, and cellular senescence rescues osteoporosis in gerodermia osteodysplastica Open
GORAB is a key regulator of Golgi vesicle transport and protein glycanation. Loss of GORAB function in gerodermia osteodysplastica (GO) causes shortening of glycosaminoglycan chains, leading to extracellular matrix disorganization that res…
View article: TGF-β induced senescence is a novel therapeutic target for treating osteoporosis in Gerodermia Osteodysplastica
TGF-β induced senescence is a novel therapeutic target for treating osteoporosis in Gerodermia Osteodysplastica Open
View article: The effects of L-Carnitine as nutrigenomic factor on gene expression under various conditions
The effects of L-Carnitine as nutrigenomic factor on gene expression under various conditions Open
HINTERGRUND: L-Carnitin hat als wichtiger nutrigenomischer Metabolit, einen enormen Einfluss auf die Genexpression. ZIELE: Das Ziel dieser Arbeit ist die Herstellung eines Vergleiches zwischen Genexpressionen der Gene BCOX1, TBDN100, STK4 …
View article: Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica
Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica Open
Gerodermia osteodysplastica (GO) is characterized by skin laxity and early-onset osteoporosis. GORAB, the responsible disease gene, encodes a small Golgi protein of poorly characterized function. To circumvent neonatal lethality of the Gor…
View article: Dysregulated TGF-β signaling and oxidative stress as the cause for osteoporosis in the progeroid disorder Gerodermia Osteodysplastica
Dysregulated TGF-β signaling and oxidative stress as the cause for osteoporosis in the progeroid disorder Gerodermia Osteodysplastica Open
Gerodermia Osteodysplastica (GO) is a premature ageing disorder characterized by wrinkled, lax skin and premature osteoporosis. GO is caused by loss-of- function mutations in GORAB, a novel Golgin with poorly understood function. This stud…