Magdalene K. Montgomery
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View article: <b>Phosphatidylserine supplementation improves metabolic liver disease and glycaemic control in the presence of suppressed oxidative glucose metabolism</b>
<b>Phosphatidylserine supplementation improves metabolic liver disease and glycaemic control in the presence of suppressed oxidative glucose metabolism</b> Open
Type 2 diabetes and obesity are commonly accompanied by metabolic dysfunction-associated steatotic liver disease (MASLD), increasing the risk of developing metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis. The early sta…
View article: Diabetic heart shows preferential secretion of inner mitochondrial membrane proteins in the presence of mitochondrial oxidative stress
Diabetic heart shows preferential secretion of inner mitochondrial membrane proteins in the presence of mitochondrial oxidative stress Open
Diabetic cardiomyopathy is a leading cause of death in patients with type 2 diabetes (T2D). Here, we show striking remodeling of cardiac protein secretion in mice with T2D, particularly an increase in the release of inner mitochondrial mem…
View article: Physiological roles of phosphoinositides and inositol phosphates: Implications for metabolic dysfunction-associated steatotic liver disease
Physiological roles of phosphoinositides and inositol phosphates: Implications for metabolic dysfunction-associated steatotic liver disease Open
Phosphoinositides and inositol phosphates (IPs) are integral to numerous cellular processes, including membrane trafficking, signal transduction and calcium dynamics. These lipid-derived signalling mediators orchestrate the spatial and tem…
View article: Integrated liver-secreted and plasma proteomics identify a predictive model that stratifies MASH
Integrated liver-secreted and plasma proteomics identify a predictive model that stratifies MASH Open
Obesity is a major risk factor for metabolic-associated steatotic liver disease (MASLD), which can progress to metabolic-associated steatohepatitis (MASH). There are no validated non-invasive tests to stratify persons with obesity with a g…
View article: HEXA-FC protein therapy increases skeletal muscle glucose uptake and improves glycaemic control in mice with insulin resistance and in a mouse model of type 2 diabetes
HEXA-FC protein therapy increases skeletal muscle glucose uptake and improves glycaemic control in mice with insulin resistance and in a mouse model of type 2 diabetes Open
Aims/hypothesis Type 2 diabetes is a chronic metabolic disorder characterised by insulin resistance and sustained hyperglycaemia, and is a major cause of blindness, kidney failure, heart attacks and stroke. Our team has recently identified…
View article: Long-lasting recombinant HEXA treatment improves hepatic steatosis and glycemic control in mild, but not severe, metabolic dysfunction-associated steatohepatitis
Long-lasting recombinant HEXA treatment improves hepatic steatosis and glycemic control in mild, but not severe, metabolic dysfunction-associated steatohepatitis Open
The prevalence of metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes is increasing. Here, we show that chronic FC-HEXA recombinant protein treatment reduces hepatic lipid accumulation and improves blood glucose con…
View article: Lipidome profiling in advanced metabolic liver disease identifies phosphatidylserine synthase 1 as a regulator of hepatic lipoprotein metabolism
Lipidome profiling in advanced metabolic liver disease identifies phosphatidylserine synthase 1 as a regulator of hepatic lipoprotein metabolism Open
Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by defective lipid metabolism, which causes disease progression. MASH is also linked to various cardiometabolic risk factors, including obesity and type 2 diabetes. T…
View article: Putting metabolism centre stage in health and disease
Putting metabolism centre stage in health and disease Open
View article: Pathogenic hypothalamic extracellular matrix promotes metabolic disease
Pathogenic hypothalamic extracellular matrix promotes metabolic disease Open
View article: Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in Amyotrophic Lateral Sclerosis
Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in Amyotrophic Lateral Sclerosis Open
Arginine methylation is a protein post-translational modification important for the development of skeletal muscle mass and function. Despite this, our understanding of the regulation of arginine methylation under settings of health and di…
View article: The GR‐KLF15 axis promotes suppression of hepatic lipogenesis during fasting
The GR‐KLF15 axis promotes suppression of hepatic lipogenesis during fasting Open
Fasting leads to many physiological changes in peripheral tissues, including the liver, where suppression of de novo lipogenesis through inhibition of sterol regulatory element‐binding protein 1 (SREBP‐1) expression and/or activity is a ke…
View article: SIRT3 overexpression in rat muscle does not ameliorate peripheral insulin resistance
SIRT3 overexpression in rat muscle does not ameliorate peripheral insulin resistance Open
Reduced expression of the NAD + -dependent deacetylase, SIRT3, has been associated with insulin resistance and metabolic dysfunction in humans and rodents. In this study, we investigated whether specific overexpression of SIRT3 in vivo in …
View article: Mechanisms underlying the efficacy of a rodent model of vertical sleeve gastrectomy — A focus on energy expenditure
Mechanisms underlying the efficacy of a rodent model of vertical sleeve gastrectomy — A focus on energy expenditure Open
Collectively, these data support a role for BAT in mediating the metabolic sequelae following VSG surgery, particularly the improvement in glucose regulation, and highlight the need to better understand the contribution from this tissue in…
View article: Mouse strain-dependent variation in metabolic associated fatty liver disease (MAFLD): a comprehensive resource tool for pre-clinical studies
Mouse strain-dependent variation in metabolic associated fatty liver disease (MAFLD): a comprehensive resource tool for pre-clinical studies Open
Non-alcoholic steatohepatitis (NASH), characterized as the joint presence of steatosis, hepatocellular ballooning and lobular inflammation, and liver fibrosis are strong contributors to liver-related and overall mortality. Despite the high…
View article: Liver-secreted Hexosaminidase A regulates insulin-like growth factor signalling and glucose transport in skeletal muscle
Liver-secreted Hexosaminidase A regulates insulin-like growth factor signalling and glucose transport in skeletal muscle Open
Non-alcoholic fatty liver disease (NAFLD) and impaired glycaemic control are closely linked, however, the pathophysiological mechanisms underpinning this bidirectional relationship remain unresolved. The high secretory capacity of the live…
View article: Liver-secreted Hexosaminidase A regulates insulin-like growth factor signalling and glucose transport in skeletal muscle
Liver-secreted Hexosaminidase A regulates insulin-like growth factor signalling and glucose transport in skeletal muscle Open
Non-alcoholic fatty liver disease (NAFLD) and impaired glycaemic control are closely linked, however, the pathophysiological mechanisms underpinning this bidirectional relationship remain unresolved. The high secretory capacity of the live…
View article: Liver-Secreted Hexosaminidase A Regulates Insulin-Like Growth Factor Signaling and Glucose Transport in Skeletal Muscle
Liver-Secreted Hexosaminidase A Regulates Insulin-Like Growth Factor Signaling and Glucose Transport in Skeletal Muscle Open
Nonalcoholic fatty liver disease (NAFLD) and impaired glycemic control are closely linked; however, the pathophysiological mechanisms underpinning this bidirectional relationship remain unresolved. The high secretory capacity of the liver …
View article: Proteomic analysis reveals exercise training induced remodelling of hepatokine secretion and uncovers syndecan-4 as a regulator of hepatic lipid metabolism
Proteomic analysis reveals exercise training induced remodelling of hepatokine secretion and uncovers syndecan-4 as a regulator of hepatic lipid metabolism Open
Remodelling of hepatokine secretion is an adaptation to regular exercise training that induces changes in metabolism in the liver and skeletal muscle. SDC4 is a novel exercise-responsive hepatokine that decreases fatty acid uptake and redu…
View article: Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control
Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control Open
Non-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, yet the pathophysiological mechanisms underpinning this bidirectional relationship remain unresolved. Using proteomic approaches, we interrogate hepatocyte protei…
View article: Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease
Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease Open
Obesity is a major risk factor underlying the development of metabolic disease and a growing public health concern globally. Strategies to promote skeletal muscle metabolism can be effective to limit the progression of metabolic disease. H…
View article: Western Diet Induced Remodelling of the Tongue Proteome
Western Diet Induced Remodelling of the Tongue Proteome Open
The tongue is a heavily innervated and vascularized striated muscle that plays an important role in vocalization, swallowing and digestion. The surface of the tongue is lined with papillae which contain gustatory cells expressing various t…
View article: EGFRvIII Promotes Cell Survival during Endoplasmic Reticulum Stress through a Reticulocalbin 1-Dependent Mechanism
EGFRvIII Promotes Cell Survival during Endoplasmic Reticulum Stress through a Reticulocalbin 1-Dependent Mechanism Open
Reticulocalbin 1 (RCN1) is an endoplasmic reticulum (ER)-residing protein, involved in promoting cell survival during pathophysiological conditions that lead to ER stress. However, the key upstream receptor tyrosine kinase that regulates R…
View article: Ectodysplasin A Is Increased in Non-Alcoholic Fatty Liver Disease, But Is Not Associated With Type 2 Diabetes
Ectodysplasin A Is Increased in Non-Alcoholic Fatty Liver Disease, But Is Not Associated With Type 2 Diabetes Open
Ectodysplasin A (EDA) was recently identified as a liver-secreted protein that is increased in the liver and plasma of obese mice and causes skeletal muscle insulin resistance. We assessed if liver and plasma EDA is associated with worseni…
View article: Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control
Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control Open
View article: Molecular regulators of lipid metabolism in the intestine – Underestimated therapeutic targets for obesity?
Molecular regulators of lipid metabolism in the intestine – Underestimated therapeutic targets for obesity? Open
The incidence of obesity and type 2 diabetes continues to rise across the globe necessitating the need to identify new therapeutic approaches to manage these diseases. In this review, we explore the potential for therapeutic interventions …
View article: Inter-organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance
Inter-organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance Open
Organelle interactions are temporally and spatially formed connections essential for normal cell function. Recent studies have shown that mitochondria interact with various cellular organelles, such as the endoplasmic reticulum, lysosomes …
View article: Data from Ectodysplasin A is increased in nonalcoholic fatty liver disease, but is not associated with type 2 diabetes.docx
Data from Ectodysplasin A is increased in nonalcoholic fatty liver disease, but is not associated with type 2 diabetes.docx Open
CONTEXT: Ectodysplasin A (EDA) was recently identified as a liver-secreted protein that is increased in the liver and plasma of obese mice and causes skeletal muscle insulin resistance.OBJECTIVE: To determine if liver and pla…
View article: Data from Ectodysplasin A is increased in nonalcoholic fatty liver disease, but is not associated with type 2 diabetes.docx
Data from Ectodysplasin A is increased in nonalcoholic fatty liver disease, but is not associated with type 2 diabetes.docx Open
CONTEXT: Ectodysplasin A (EDA) was recently identified as a liver-secreted protein that is increased in the liver and plasma of obese mice and causes skeletal muscle insulin resistance.OBJECTIVE: To determine if liver and pla…
View article: Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity
Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity Open
View article: Regulation of mitochondrial metabolism in murine skeletal muscle by the medium‐chain fatty acid receptor Gpr84
Regulation of mitochondrial metabolism in murine skeletal muscle by the medium‐chain fatty acid receptor Gpr84 Open
Fatty acid receptors have been recognized as important players in glycaemic control. This study is the first to describe a role for the medium‐chain fatty acid (MCFA) receptor G‐protein‐coupled receptor (Gpr) 84 in skeletal muscle mitochon…