Magdalene So
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View article: Comparison of Patient-Specific Plates and Pre-Bent Plates for Preserving Condylar Position in Mandible Reconstruction
Comparison of Patient-Specific Plates and Pre-Bent Plates for Preserving Condylar Position in Mandible Reconstruction Open
Objectives: To compare the efficacy of patient-specific 3-dimensional (3D)-printed plates (PSP) and pre-bent universal reconstruction plates (PBP) in preserving the 3D position of the mandibular condyle and total operation time during mand…
View article: Zap the clap with DNA: a novel microbicide for preventing <i>Neisseria gonorrhoeae</i> infection
Zap the clap with DNA: a novel microbicide for preventing <i>Neisseria gonorrhoeae</i> infection Open
Each year, Neisseria gonorrhoeae (Ngo) causes over 1.5 million new infections in the United States, and >87 million worldwide. The absence of a vaccine for preventing gonorrhea, the rapid emergence of multidrug-resistant and extremely drug…
View article: Type IV pilus retraction is required for <i>Neisseria musculi</i> colonization and persistence in a natural mouse model of infection
Type IV pilus retraction is required for <i>Neisseria musculi</i> colonization and persistence in a natural mouse model of infection Open
Retraction of the pathogenic Neisseria Type IV pilus (Tfp) requires PilT, the primary retraction motor, and its paralogs PilU and PilT2. The importance of Tfp retraction for natural infection is unknown. Using our natural animal model of N…
View article: P031 CKD-506, a new histone deacetylase 6 inhibitor, suppresses immune cells and restores intestinal epithelial function
P031 CKD-506, a new histone deacetylase 6 inhibitor, suppresses immune cells and restores intestinal epithelial function Open
Background Inflammatory bowel disease (IBD) represents a group of chronic immune-mediated diseases of the gastrointestinal tract, characterized by recurrent inflammation and consequential damage of the gastrointestinal tract. Histone deace…
View article: Neisseria genes required for persistence identified via in vivo screening of a transposon mutant library
Neisseria genes required for persistence identified via in vivo screening of a transposon mutant library Open
The mechanisms used by human adapted commensal Neisseria to shape and maintain a niche in their host are poorly defined. These organisms are common members of the mucosal microbiota and share many putative host interaction factors with Nei…
View article: <i>In vitro</i>phenotypic and transcriptomic variation in<i>Neisseria musculi</i>morphotypes correlate with colonization variability and persistence<i>in vivo</i>
<i>In vitro</i>phenotypic and transcriptomic variation in<i>Neisseria musculi</i>morphotypes correlate with colonization variability and persistence<i>in vivo</i> Open
Asymptomatic colonization of the upper respiratory tract is a common trait of the two human restricted pathogens, Neisseria gonorrhoeae and Neisseria meningitidis. In vivo models of pathogenic neisserial infections are heterologous systems…
View article: CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae
CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae Open
The Neisseria type IV pilus promotes bacterial adhesion to host cells. The pilus binds CD46, a complement-regulatory glycoprotein present on nucleated human cells (Källström et al., 1997). CD46 mutants with truncated cytoplasmic tails fail…
View article: Tribal warfare: Commensal Neisseria kill pathogen Neisseria gonorrhoeae using its DNA
Tribal warfare: Commensal Neisseria kill pathogen Neisseria gonorrhoeae using its DNA Open
It is now abundantly clear that our microbiota (commensals) are critical for many physiological and developmental processes. They have also been shown to inhibit pathogen colonization, through a variety of means including nutrient competit…
View article: Commensal Neisseria kill Neisseria gonorrhoeae through a DNA-dependent mechanism. Kim et al.
Commensal Neisseria kill Neisseria gonorrhoeae through a DNA-dependent mechanism. Kim et al. Open
Fasta (quiver) and gff.gz files generated from PacBio Single Molecule, Real-Time sequencing of Neisseria elongata chromosome. Overview Excel file contains base calling accuracy and quality of sequencing reads. These data were used to deter…
View article: Neisseria gonorrhoeae evades autophagic killing by downregulating CD46-cyt1 and remodeling lysosomes
Neisseria gonorrhoeae evades autophagic killing by downregulating CD46-cyt1 and remodeling lysosomes Open
The Gram-negative human pathogen N. gonorrhoeae (Ngo) quickly attaches to epithelial cells, and large numbers of the bacteria remain on the cell surface for prolonged periods. Ngo invades cells but few viable intracellular bacteria are rec…
View article: The Commensal <i>Neisseria musculi</i> Modulates Host Innate Immunity To Promote Oral Colonization
The Commensal <i>Neisseria musculi</i> Modulates Host Innate Immunity To Promote Oral Colonization Open
Neisseria musculi, isolated from the oral cavity of wild-caught mice, does not colonize most inbred mouse strains. N. musculi does weakly (50%) colonize C57BL/6J (B6) mice but readily colonizes CAST/EiJ (CAST) mice. In this study, we exami…
View article: RpoN and the Nps and Npa two‐component regulatory system control <i>pilE</i> transcription in commensal <i>Neisseria</i>
RpoN and the Nps and Npa two‐component regulatory system control <i>pilE</i> transcription in commensal <i>Neisseria</i> Open
Over 20 genes are involved in the biogenesis and function of the Neisseria Type IV pilus (Tfp). In the pathogenic species, RpoD and the integration host factor (IHF) protein regulate expression of pilE , encoding the Tfp structural subunit…
View article: A Natural Mouse Model for Neisseria Colonization
A Natural Mouse Model for Neisseria Colonization Open
Commensals are important for the proper functioning of multicellular organisms. How a commensal establishes persistent colonization of its host is little understood. Studies of this aspect of microbe-host interactions are impeded by the ab…
View article: Human Three-Dimensional Endometrial Epithelial Cell Model To Study Host Interactions with Vaginal Bacteria and Neisseria gonorrhoeae
Human Three-Dimensional Endometrial Epithelial Cell Model To Study Host Interactions with Vaginal Bacteria and Neisseria gonorrhoeae Open
Colonization of the endometrium by pathogenic bacteria ascending from the lower female reproductive tract (FRT) is associated with many gynecologic and obstetric health complications. To study these host-microbe interactions in vitro , we …
View article: Attenuation of the Type IV Pilus Retraction Motor Influences Neisseria gonorrhoeae Social and Infection Behavior
Attenuation of the Type IV Pilus Retraction Motor Influences Neisseria gonorrhoeae Social and Infection Behavior Open
Retraction of the type IV pilus (Tfp) mediates DNA uptake, motility, and social and infection behavior in a wide variety of prokaryotes. To date, investigations into Tfp retraction-dependent activities have used a mutant deleted of PilT, t…
View article: Isolation and characterization of Neisseria musculi sp. nov., from the wild house mouse
Isolation and characterization of Neisseria musculi sp. nov., from the wild house mouse Open
Members of the genus Neisseria have been isolated from or detected in a wide range of animals, from non-human primates and felids to a rodent, the guinea pig. By means of selective culture, biochemical testing, Gram staining and PCR screen…