Maged F. Serag
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View article: Combined TIRF and 3D Super-Resolution Microscopy for Nanoscopic Spatiotemporal Characterization of Adhesion Molecules on Microvilli
Combined TIRF and 3D Super-Resolution Microscopy for Nanoscopic Spatiotemporal Characterization of Adhesion Molecules on Microvilli Open
The homing of hematopoietic stem/progenitor cells (HSPCs) and leukemic cells is a multistep process governed by complex spatiotemporal interactions between adhesion molecules under shear stress. While the molecular and biological mechanism…
View article: Fluorescent Labeling of Ultrahigh Molecular Weight Polyacrylamide Polymers in Microemulsion Systems
Fluorescent Labeling of Ultrahigh Molecular Weight Polyacrylamide Polymers in Microemulsion Systems Open
Fluorescent labeling of ultrahigh molecular weight polymers is crucial for understanding their behavior in complex environments yet remains challenging due to purification difficulties. Here, we present an efficient postpolymerization labe…
View article: Deep Learning and Single-Molecule Localization Microscopy Reveal Nanoscopic Dynamics of DNA Entanglement Loci
Deep Learning and Single-Molecule Localization Microscopy Reveal Nanoscopic Dynamics of DNA Entanglement Loci Open
Understanding molecular dynamics at the nanoscale remains challenging due to limitations in the temporal resolution of current imaging techniques. Deep learning integrated with Single-Molecule Localization Microscopy (SMLM) offers opportun…
View article: PRC2-EZH1 contributes to circadian gene expression by orchestrating chromatin states and RNA polymerase II complex stability
PRC2-EZH1 contributes to circadian gene expression by orchestrating chromatin states and RNA polymerase II complex stability Open
Circadian rhythmicity of gene expression is a conserved feature of cell physiology. This involves fine-tuning between transcriptional and post-transcriptional mechanisms and strongly depends on the metabolic state of the cell. Together the…
View article: Self-Assembly of Geometry-Based DNA Origami-Histone Protein Hybrid Nanostructures for Constructing Rationally-Designed Higher-Order Structures
Self-Assembly of Geometry-Based DNA Origami-Histone Protein Hybrid Nanostructures for Constructing Rationally-Designed Higher-Order Structures Open
The emergence of hybrid DNA–protein hybrid nanostructures in recent years has expanded the application of DNA nanotechnology. Previous studies reported the integration of proteins into DNA nanostructures by sequence-dependent interactions …
View article: Experimental and numerical investigation of polymer pore-clogging in micromodels
Experimental and numerical investigation of polymer pore-clogging in micromodels Open
View article: A single-molecule study on polymer fluid dynamics in porous media
A single-molecule study on polymer fluid dynamics in porous media Open
Understanding the dynamic behavior of polymeric fluids in porous media is essential for vast geoscience applications, particularly enhanced oil recovery and polymer-enhanced soil washing, to clean up soil contamination.
View article: Experimental and Numerical Investigation of Polymer Pore-Clogging in Micromodels
Experimental and Numerical Investigation of Polymer Pore-Clogging in Micromodels Open
Polymers have been used effectively in the Oil & Gas Industry for a variety of field applications, such as enhanced oil recovery (EOR), well conformance, mobility control, and others. Polymer intermolecular interactions with the porous roc…
View article: DNA–Carbon Nanotube Binding Mode Determines the Efficiency of Carbon Nanotube-Mediated DNA Delivery to Intact Plants
DNA–Carbon Nanotube Binding Mode Determines the Efficiency of Carbon Nanotube-Mediated DNA Delivery to Intact Plants Open
Efficient delivery of DNA, RNA, and genome engineering machinery to plant cells will enable efforts to genetically modify plants for global food security, sustainable energy production, synthetic biology applications, and climate change re…
View article: Experimental and Numerical Investigation of Polymer Pore-Clogging in Micromodels
Experimental and Numerical Investigation of Polymer Pore-Clogging in Micromodels Open
View article: The DNA–carbon nanotube binding mode determines the efficiency of carbon nanotube-mediated DNA delivery to intact plants
The DNA–carbon nanotube binding mode determines the efficiency of carbon nanotube-mediated DNA delivery to intact plants Open
Efficient delivery of DNA, RNA, and genome engineering machinery to plant cells will enable efforts to genetically modify plants for global food security, sustainable energy production, synthetic biology applications, and climate change re…
View article: The DNA–carbon nanotube binding mode determines the efficiency of carbon nanotube-mediated DNA delivery to intact plants
The DNA–carbon nanotube binding mode determines the efficiency of carbon nanotube-mediated DNA delivery to intact plants Open
Efficient delivery of DNA, RNA, and genome engineering machinery to plant cells will enable efforts to genetically modify plants for global food security, sustainable energy production, synthetic biology applications, and climate change re…
View article: Single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling
Single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling Open
View article: Single-Molecule Imaging and Microfluidic Platform Reveal Molecular Mechanisms of Leukemic Cell Rolling
Single-Molecule Imaging and Microfluidic Platform Reveal Molecular Mechanisms of Leukemic Cell Rolling Open
Hematopoietic stem/progenitor cell (HSPC) and leukemic cell homing is an important biological phenomenon that occurs through key interactions between adhesion molecules. Tethering and rolling of the cells on endothelium, the crucial initia…
View article: Spatial Confinement and Temporal Dynamics of Selectin Ligands Enable Stable Hematopoietic Stem Cell Rolling
Spatial Confinement and Temporal Dynamics of Selectin Ligands Enable Stable Hematopoietic Stem Cell Rolling Open
View article: Geometry-Based Self-Assembly of Histone–DNA Nanostructures at Single-Nucleotide Resolution
Geometry-Based Self-Assembly of Histone–DNA Nanostructures at Single-Nucleotide Resolution Open
Histones are basic protein monomers capable of interacting with DNA, providing the mechanism of DNA compaction inside the cell nucleus. The well-ordered assembly process of histone and DNA is a potential candidate as the approach for build…
View article: Entangled polymer dynamics beyond reptation
Entangled polymer dynamics beyond reptation Open
View article: Conserved linear dynamics of single-molecule Brownian motion
Conserved linear dynamics of single-molecule Brownian motion Open
Macromolecular diffusion in homogeneous fluid at length scales greater than the size of the molecule is regarded as a random process. The mean-squared displacement (MSD) of molecules in this regime increases linearly with time. Here we sho…