Explanipedia

Phosphorylation of cell cycle and apoptosis regulatory protein-1 by stress activated protein kinase P38γ is a novel mechanism of apoptosis signaling by genotoxic chemotherapy Open

Jaganathan Venkatesh, Magesh Muthu, Indulekha Singaravelu, Vino T. Cheriyan, Sreeja C. Sekhar , et al. · 2024

CARP-1, a perinuclear phospho-protein, regulates cell survival and apoptosis signaling induced by genotoxic drugs. However, kinase(s) phosphorylating CARP-1 and down-stream signal transduction events remain unclear. Here we find that CARP-…

Exopolysaccharides Derived from Probiotic Bacteria and their Health Benefits Open

Thejaswi Bhandary, Christine Kurian, Magesh Muthu, Asha Anand, Thirunavukarasou Anand , et al. · 2023

Probiotic bacteria are producers of secretory products such as bacteriocins and polysaccharides. Both homopolymeric and heteropolymeric exopolysaccharides (EPS) present on the surface of microorganisms have shown beneficial properties. Whi…

Unique peptidic agonists of a juvenile hormone receptor with species-specific effects on insect development and reproduction Open

Sarka Tumova, Matěj Miláček, Ivan Šnajdr, Magesh Muthu, Roman Tůma , et al. · 2022

Juvenile hormones (JHs) control insect metamorphosis and reproduction. JHs act through a receptor complex consisting of methoprene-tolerant (Met) and taiman (Tai) proteins to induce transcription of specific genes. Among chemically diverse…

Traumatic small bowel perforation Open

Vikas Shah, Magesh Muthu · 2020

Sigmoid volvulus Open

Mostafa El-Feky, Magesh Muthu · 2020

Non occlusive mesenteric ischemia Open

Vikas Shah, Magesh Muthu · 2020

Type A aortic dissection Open

Henry Knipe, Magesh Muthu · 2020

Incarcerated umblical hernia Open

Mostafa El-Feky, Magesh Muthu · 2020

Ancient schwannoma Open

Magesh Muthu · 2020

Diffuse panbronchiolitis Open

Henry Knipe, Magesh Muthu · 2020

Hepatoblastoma Open

Tee Jin, Magesh Muthu · 2020

Dorsal thoracic arachnoid web Open

Mostafa El-Feky, Magesh Muthu · 2020

Antagonizing binding of cell cycle and apoptosis regulatory protein 1 (CARP-1) to the NEMO/IKKγ protein enhances the anticancer effect of chemotherapy Open

Jaganathan Venkatesh, Sreeja C. Sekhar, Vino T. Cheriyan, Magesh Muthu, Paul Meister , et al. · 2020

NF-κB is a pro-inflammatory transcription factor that critically regulates immune responses and other distinct cellular pathways. However, many NF-κB-mediated pathways for cell survival and apoptosis signaling in cancer remain to be elucid…

GLUL Ablation Can Confer Drug Resistance to Cancer Cells via a Malate-Aspartate Shuttle-Mediated Mechanism Open

Magesh Muthu, Ranjeet Kumar, Azharuddin Sajid Syed Khaja, Jonathan D. Gilthorpe, Jenny L. Persson , et al. · 2019

Glutamate-ammonia ligase (GLUL) is important for acid-base homeostasis, ammonia detoxification, cell signaling, and proliferation. Here, we reported that GLUL ablation conferred resistance to several anticancer drugs in specific cancer cel…

Adrenal haemangioma Open

Henry Knipe, Magesh Muthu · 2019

Pulmonary arteriovenous malformations Open

Pir Abdul Ahad Qureshi, Magesh Muthu · 2019

Current Status and Future Prospects of Clinically Exploiting Cancer-specific Metabolism—Why Is Tumor Metabolism Not More Extensively Translated into Clinical Targets and Biomarkers? Open

Magesh Muthu, Anders Nordström · 2019

Tumor cells exhibit a specialized metabolism supporting their superior ability for rapid proliferation, migration, and apoptotic evasion. It is reasonable to assume that the specific metabolic needs of the tumor cells can offer an array of…

A H2AX–CARP-1 Interaction Regulates Apoptosis Signaling Following DNA Damage Open

Sreeja C. Sekhar, Jaganathan Venkatesh, Vino T. Cheriyan, Magesh Muthu, Edi Levi , et al. · 2019

Cell Cycle and Apoptosis Regulatory Protein (CARP-1/CCAR1) is a peri-nuclear phosphoprotein that regulates apoptosis via chemotherapeutic Adriamycin (doxorubicin) and a novel class of CARP-1 functional mimetic (CFM) compounds. Although Adr…

Enchondroma Open

Henry Knipe, Magesh Muthu · 2019

Endobronchial carcinoid Open

Avni Skandhan, Magesh Muthu · 2018

A CARP-1 functional mimetic compound is synergistic with BRAF-targeting in non-small cell lung cancers Open

Vino T. Cheriyan, Hashem O. Alsaab, Sreeja C. Sekhar, Jaganathan Venkatesh, Arindam Mondal , et al. · 2018

Non-small cell lung cancers (NSCLC) account for 85% of all lung cancers, and the epidermal growth factor receptor (EGFR) is highly expressed or activated in many NSCLC that permit use of EGFR tyrosine kinase inhibitors (TKIs) as frontline …

PO-249 GLUL knockdown induces drug resistance in non-small cell lung cancer cells Open

Magesh Muthu, Anders Nordström · 2018

Introduction Chemotherapy has advanced well in the treatment of Non-Small Cell Lung Cancers (NSCLCs), but its effectiveness is limited by drug resistance. Unfortunately, cancer drug resistance becoming inevitable involving alterations in …

Pilocytic astrocytoma Open

Francis Fortin, Magesh Muthu · 2018

Morgagni hernia Open

Yuranga Weerakkody, Magesh Muthu · 2018

Hydatid cyst with daughter cysts Open

Henry Knipe, Magesh Muthu · 2018

A CARP-1 functional mimetic loaded vitamin E-TPGS micellar nano-formulation for inhibition of renal cell carcinoma Open

Vino T. Cheriyan, Hashem O. Alsaab, Sreeja C. Sekhar, Caitlin Stieber, Prashant Kesharwani , et al. · 2017

Current treatments for Renal Cell Carcinoma (RCC) include a combination of surgery, targeted therapy, and immunotherapy. Emergence of resistant RCCs contributes to failure of drugs and poor prognosis, and thus warrants development of new a…

Brachial plexus injury Open

Yuranga Weerakkody, Magesh Muthu · 2017

Synovial sarcoma Open

Henry Knipe, Magesh Muthu · 2017

Uterine choriocarcinoma Open

Magesh Muthu · 2017

Ovarian torsion Open

Ammar Haouimi, Magesh Muthu · 2017

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