Matthew A. Smith
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Synthetic-data-driven LSTM framework for tracing cardiac pulsation in optical signals Open
Optical monitoring of cardiac pulsations using near-infrared spectroscopy (NIRS), photoplethysmography (PPG), and diffuse correlation spectroscopy (DCS) is often hindered by motion artifacts and noise. We introduce a synthetic-data-driven …
Brain-wide arousal signals are segregated from movement planning in the superior colliculus Open
The superior colliculus (SC) is traditionally considered a brain region that functions as an interface between processing visual inputs and generating eye movement outputs. Although its role as a primary reflex center is thought to be cons…
Interactions across hemispheres in prefrontal cortex reflect global cognitive processing Open
SUMMARY Brain functions involve processing in local networks as well as modulation from brainwide signals, such as arousal. Dissecting the contributions of populations of neurons to these functions requires knowledge of interactions betwee…
Robustness of Working Memory to Prefrontal Cortex Microstimulation Open
Delay period activity in the dorsolateral prefrontal cortex (dlPFC) has been linked to the maintenance and control of sensory information in working memory. The stability of working memory-related signals found in such delay period activit…
Redundant prefrontal hemispheres adapt storage strategy to working memory demands Open
The prefrontal hemispheres must coordinate dynamically to maintain a unified representation of visual space. Recently, two opposing theories using distinct storage strategies have been proposed: A high-capacity specialized architecture, wh…
Robustness of working memory to prefrontal cortex microstimulation Open
Delay period activity in the dorso-lateral prefrontal cortex (dlPFC) has been linked to the maintenance and control of sensory information in working memory. The stability of working memory related signals found in such delay period activi…
Transcranial focused ultrasound remotely modulates extrastriate visual cortex by stimulating frontal eye field with subregion specificity Open
Objective. Low-intensity transcranial focused ultrasound (tFUS) has emerged as a powerful neuromodulation tool characterized by its deep penetration and precise spatial targeting to influence neural activity. Our study directed low-intensi…
Recent Visual Experience Reshapes V4 Neuronal Activity and Improves Perceptual Performance Open
Recent visual experience heavily influences our visual perception, but how neuronal activity is reshaped to alter and improve perceptual discrimination remains unknown. We recorded from populations of neurons in visual cortical area V4 whi…
Brain-wide arousal signals are segregated from movement planning in the superior colliculus Open
The superior colliculus (SC) is traditionally considered a brain region that functions as an interface between processing visual inputs and generating eye movement outputs. Although its role as a primary reflex center is thought to be cons…
Brain-wide arousal signals are segregated from movement planning in the superior colliculus Open
The superior colliculus (SC) is traditionally considered a brain region that functions as an interface between processing visual inputs and generating eye movement outputs. Although its role as a primary reflex center is thought to be cons…
Brain-wide arousal signals are segregated from movement planning in the superior colliculus Open
The superior colliculus (SC) is traditionally considered a brain region that functions as an interface between processing visual inputs and generating eye movement outputs. Although its role as a primary reflex center is thought to be cons…
Transcranial Focused Ultrasound Remotely Modulates Extrastriate Visual Cortex with Subregion Specificity Open
Low-intensity transcranial focused ultrasound (tFUS) has emerged as a powerful neuromodulation tool characterized by its deep penetration and precise spatial targeting to influence neural activity. Our study directed low-intensity tFUS sti…
Transcranial focused ultrasound neuromodulation on a nonhuman primate model Open
In these datasets, we applied low-intensity tFUS stimulation with a customized 128-element random array ultrasound transducer (f0: 700 kHz) in a rhesus macaque monkey engaged in a simple visually-guided saccade task. The stimulation was gu…
Compact deep neural network models of visual cortex Open
A powerful approach to understanding the computations carried out in visual cortex is to develop models that predict neural responses to arbitrary images. Deep neural network (DNN) models have worked remarkably well at predicting neural re…
View article: Automated customization of large-scale spiking network models to neuronal population activity
Automated customization of large-scale spiking network models to neuronal population activity Open
Understanding brain function is facilitated by constructing computational models that accurately reproduce aspects of brain activity. Networks of spiking neurons capture the underlying biophysics of neuronal circuits, yet the dependence of…
Recent visual experience reshapes V4 neuronal activity and improves perceptual performance Open
Recent visual experience heavily influences our visual perception, but how this is mediated by the reshaping of neuronal activity to alter and improve perceptual discrimination remains unknown. We recorded from populations of neurons in vi…
The eyes as a window to internal fluctuations in global brain state Open
On a daily basis, we perform a variety of perceptual tasks that depend on the precise encoding of sensory information. Our performance on these tasks is modulated by the internal state of the brain with respect to ongoing fluctuations in a…
In vivo Modulation of Intraocular and Intracranial Pressures Causes Nonlinear and Non-monotonic Deformations of the Lamina Cribrosa and Scleral Canal Open
Purpose To evaluate changes in monkey optic nerve head (ONH) morphology under acutely controlled intraocular pressure (IOP) and intracranial pressure (ICP). Methods Seven ONHs from six monkeys were imaged via optical coherence tomography w…
Cerebrovascular Impedance as a Function of Cerebral Perfusion Pressure Open
Goal: Cerebrovascular impedance is modulated by a vasoactive autoregulative mechanism in response to changes in cerebral perfusion pressure. Characterization of impedance and the limits of autoregulation are important biomarkers of cerebra…
Using near-infrared spectroscopy and a random forest regressor to estimate intracranial pressure Open
This study provides a proof of concept for the use of NIRS in noninvasive ICP estimation.
View article: Comparing acute IOP-induced lamina cribrosa deformations pre-mortem and post-mortem
Comparing acute IOP-induced lamina cribrosa deformations pre-mortem and post-mortem Open
Purpose Lamina cribrosa (LC) deformations caused by elevated intraocular pressure (IOP) are believed to contribute to glaucomatous neuropathy and have therefore been extensively studied, in many conditions from in-vivo to ex-vivo. We compa…
View article: Non-Invasive Spectroscopy for Measuring Cerebral Tissue Oxygenation and Metabolism as a Function of Cerebral Perfusion Pressure
Non-Invasive Spectroscopy for Measuring Cerebral Tissue Oxygenation and Metabolism as a Function of Cerebral Perfusion Pressure Open
Near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS) measure cerebral hemodynamics, which in turn can be used to assess the cerebral metabolic rate of oxygen (CMRO2) and cerebral autoregulation (CA). However, curren…
View article: EEG Signals Index a Global Signature of Arousal Embedded in Neuronal Population Recordings
EEG Signals Index a Global Signature of Arousal Embedded in Neuronal Population Recordings Open
Electroencephalography (EEG) has long been used to index brain states, from early studies describing activity in the presence and absence of visual stimulation to modern work employing complex perceptual tasks. These studies have shed ligh…
Changes in neurovascular coupling with cerebral perfusion pressure indicate a link to cerebral autoregulation Open
Cerebral autoregulation ensures a stable average blood supply to brain tissue across steady state cerebral perfusion pressure (CPP) levels. Neurovascular coupling, in turn, relies on sufficient blood flow to meet neuronal demands during ac…
PhysiologicalData.zip Open
Comparison of static and dynamic cerebral autoregulation under anesthesia influence in a controlled animal model Abstract The brain’s ability to maintain cerebral blood flow approximately constant despite cerebral perfusion pressure change…
PhysiologicalData.zip Open
Comparison of static and dynamic cerebral autoregulation under anesthesia influence in a controlled animal modelAbstractThe brain’s ability to maintain cerebral blood flow approximately constant despite cerebral perfusion pressure changes …