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View article: Folic Acid-Decorated Lipidic Nanocapsules Co-Loaded with Atorvastatin and Curcumin to Enhance Glioma Targeting in Mice
Folic Acid-Decorated Lipidic Nanocapsules Co-Loaded with Atorvastatin and Curcumin to Enhance Glioma Targeting in Mice Open
Background: Glioma remains an intractable and highly aggressive brain tumor, mainly due to the daunting obstacle presented by the blood–brain barrier (BBB). To overcome this challenge and enhance therapeutic efficacy, a dual-drug delivery …
View article: Verification of the anticholinesterase activity of Tectona grandis and Rosemarinus officinalis in vitro and in silico
Verification of the anticholinesterase activity of Tectona grandis and Rosemarinus officinalis in vitro and in silico Open
View article: From Olive Tree to Treatment: Nano-Delivery Systems for Enhancing Oleuropein’s Health Benefits
From Olive Tree to Treatment: Nano-Delivery Systems for Enhancing Oleuropein’s Health Benefits Open
Oleuropein is a natural polyphenolic compound isolated from olive trees (Olea europaea). Besides the strong antioxidant effect of oleuropein, it has many pharmacological activities such as anticancer, antidiabetic, anti-inflammatory, antih…
View article: An Enhanced Solar Battery Charger Using a DC-DC Single-Ended Primary-Inductor Converter and Fuzzy Logic-Based Control for Off-Grid Photovoltaic Applications
An Enhanced Solar Battery Charger Using a DC-DC Single-Ended Primary-Inductor Converter and Fuzzy Logic-Based Control for Off-Grid Photovoltaic Applications Open
Battery charging systems are crucial for energy storage in off-grid photovoltaic (PV) installations. Since the power generated by a PV panel is conditioned by climatic conditions and load characteristics, a maximum power point tracking (MP…
View article: Improved Control of Grid-Connected Converters from Strong to Very Weak Conditions Integrating More Effective Lmis and C-Hil
Improved Control of Grid-Connected Converters from Strong to Very Weak Conditions Integrating More Effective Lmis and C-Hil Open
View article: Antimicrobial photodynamic inactivation and photosensitizers: A succinct review
Antimicrobial photodynamic inactivation and photosensitizers: A succinct review Open
View article: Assessment of Mesiobuccal Root Canal Curvature in Maxillary Molars of Egyptian Population: A Standardized CBCT-Based Radiographic Protocol
Assessment of Mesiobuccal Root Canal Curvature in Maxillary Molars of Egyptian Population: A Standardized CBCT-Based Radiographic Protocol Open
Aim: This cross-sectional study aims to analyze the mesiobuccal (MB) root canal curvature in maxillary molars of the Egyptian population using cone-beam computed tomography (CBCT). Material and methods: DICOM files were retrieved anonymous…
View article: Deciphering the dynamics of methicillin-resistant Staphylococcus aureus biofilm formation: from molecular signaling to nanotherapeutic advances
Deciphering the dynamics of methicillin-resistant Staphylococcus aureus biofilm formation: from molecular signaling to nanotherapeutic advances Open
Methicillin-resistant Staphylococcus aureus (MRSA) represents a global threat, necessitating the development of effective solutions to combat this emerging superbug. In response to selective pressures within healthcare, community, and live…
View article: Gastroprotective Chitosan Nanoparticles Loaded with Oleuropein: An In Vivo Proof of Concept
Gastroprotective Chitosan Nanoparticles Loaded with Oleuropein: An In Vivo Proof of Concept Open
Oleuropein is the main constituent of olive leaf extract, and it has shown antioxidant and gastroprotective properties against gastric ulcers. Chitosan nanoparticles are known for their mucoadhesive abilities, and consequently, they can in…
View article: Topical sodium valproate-loaded nanospanlastics versus conventional topical steroid therapy in alopecia areata: a randomized controlled study
Topical sodium valproate-loaded nanospanlastics versus conventional topical steroid therapy in alopecia areata: a randomized controlled study Open
Background A myriad of therapeutic modalities for alopecia areata are available; however, none is of high level of evidence, creating an immense need for the evaluation of other treatment modalities, of which topical sodium valproate is of…
View article: Preparation and characterization of mangiferin-loaded lipid nanocapsules
Preparation and characterization of mangiferin-loaded lipid nanocapsules Open
Mangiferin (Mgf), a xanthone glucoside of natural origin, is well known to possess different pharmacological actions such as analgesic, antiviral, antidiabetic, anti-inflammatory, hepatoprotective, and antitumor.However, concerning water s…
View article: Development and in Vitro/In Vivo Evaluation of Itopride Hydrochloride Expanding Tablets
Development and in Vitro/In Vivo Evaluation of Itopride Hydrochloride Expanding Tablets Open
Purpose Gastroretentive drug delivery systems (GRDDS) have attracted interest for enhancement of absorption and bioavailability of some drugs. Itopride hydrochloride (ITOP) is a drug used for treatment of gastroesophageal reflux and other …
View article: Curcumin-resveratrol nano-formulation counteracting hyperammonemia in rats
Curcumin-resveratrol nano-formulation counteracting hyperammonemia in rats Open
View article: Intranasal ondansetron microemulsion counteracting the adverse effects of cisplatin: animal study
Intranasal ondansetron microemulsion counteracting the adverse effects of cisplatin: animal study Open
Background Cisplatin is considered one of the most effective and commonly used chemotherapeutic drugs, but despite its high therapeutic effectiveness, most patients treated with cisplatin suffer from nausea and vomiting, neurotoxic side ef…
View article: Current progress of oral site-specific dosage forms: Emphasis on gastroretentive drug delivery systems
Current progress of oral site-specific dosage forms: Emphasis on gastroretentive drug delivery systems Open
The oral route of administration is considered the easiest, most convenient and widely used drug delivery route. One of the hardest challenges facing oral drug delivery systems (DDS) is the erratic absorption of drugs through the gastroint…
View article: Gold-Polypyrrole-Loaded Eosin in Photo-Mediated Treatment of Hidradenitis Suppurativa: In Vivo Trans-Epidermal Permeation Study and Clinical Case Report
Gold-Polypyrrole-Loaded Eosin in Photo-Mediated Treatment of Hidradenitis Suppurativa: In Vivo Trans-Epidermal Permeation Study and Clinical Case Report Open
This study reports a new protocol for the management of Hidradenitis Suppurativa (HS), depending on the synergistic photodynamic and photothermal effect of eosin yellow-gold-polypyrrole hybrid nanoparticles (E-G-Ppy NPs). E-G-Ppy NPs and g…
View article: Recent Formulation Advances of Mangiferin
Recent Formulation Advances of Mangiferin Open
Nutraceuticals have recently gained interest owing to their valuable contribution in the treatment of several diseases, with high safety margin and low incidence of side effects. However, their efficacy is limited by some challenges, namel…
View article: Nose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality
Nose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality Open
Ischemic stroke accounts for about 87% of all strokes, causing long-term disability in adults, and is the second leading cause of death worldwide. In search of new therapeutic modalities, the use of neuroprotective agents loaded in nanocar…
View article: Optimization of the colloidal properties of chitosan nanoparticles encapsulating alpha-arbutin
Optimization of the colloidal properties of chitosan nanoparticles encapsulating alpha-arbutin Open
Melasma is a highly prevalent skin disorder in which patients exhibit hyperpigmented patches on face. This provokes the essentiality to search for effective treatment strategies, among which are the topical nanosystems. The current study a…
View article: Functionalized chitosan nanoparticles for cutaneous delivery of a skin whitening agent: an approach to clinically augment the therapeutic efficacy for melasma treatment
Functionalized chitosan nanoparticles for cutaneous delivery of a skin whitening agent: an approach to clinically augment the therapeutic efficacy for melasma treatment Open
The increase in the production of melanin level inside the skin prompts a patient-inconvenient skin color disorder namely; melasma. This arouses the need to develop efficacious treatment modalities, among which are topical nano-delivery sy…
View article: Call for papers: Exploiting extracellular vesicles as therapeutic agents
Call for papers: Exploiting extracellular vesicles as therapeutic agents Open
View article: New repurposed rolapitant in nanovesicular systems for lung cancer treatment: Development, in-vitro assessment and in-vivo biodistribution study
New repurposed rolapitant in nanovesicular systems for lung cancer treatment: Development, in-vitro assessment and in-vivo biodistribution study Open
Lung cancer is characterized by poor prognosis, and is considered a serious disease that causes a significant mortality. The available conventional chemotherapeutic agents suffer from several limitations; hence, new drug molecules are cons…
View article: Simultaneous pulmonary administration of celecoxib and naringin using a nebulization-friendly nanoemulsion: A device-targeted delivery for treatment of lung cancer
Simultaneous pulmonary administration of celecoxib and naringin using a nebulization-friendly nanoemulsion: A device-targeted delivery for treatment of lung cancer Open
Lung cancer is a principal cause of death worldwide, and its treatment is very challenging. Nebulization offers a promising means of targeting drugs to their site of action in the lung. In the present study, nebulizable oil in water nanoem…
View article: Baicalin lipid nanocapsules for treatment of glioma: characterization, mechanistic cytotoxicity, and pharmacokinetic evaluation
Baicalin lipid nanocapsules for treatment of glioma: characterization, mechanistic cytotoxicity, and pharmacokinetic evaluation Open
Baicalin is a promising anticancer nutraceutical compound, but its application is hindered by its low water solubility and bioavailability, which can be remedied by its encapsulation in nanoparticles. Lipid nanocapsules (LNCs) were develop…
View article: (Rose Bengal)/(Eosin Yellow)-Gold-Polypyrrole Hybrids: A Design for Dual Photo-Active Nano-System with Ultra-High Loading Capacity
(Rose Bengal)/(Eosin Yellow)-Gold-Polypyrrole Hybrids: A Design for Dual Photo-Active Nano-System with Ultra-High Loading Capacity Open
Gold-polypyrrole nanoparticles represent an effective delivery system to improve the photodynamic and photothermal properties of RB and EY. The in situ one-pot synthesis method provided a means to greatly increase the loading capacity of A…
View article: Nobiletin-loaded composite penetration enhancer vesicles restore the normal miRNA expression and the chief defence antioxidant levels in skin cancer
Nobiletin-loaded composite penetration enhancer vesicles restore the normal miRNA expression and the chief defence antioxidant levels in skin cancer Open
View article: Vesicular Systems Used for Wound Healing
Vesicular Systems Used for Wound Healing Open
When the skin is injured through physical, chemical, mechanical, and/or thermal damage, a spontaneous series of events start to happen, often called the “cascade of healing,” so as to restore the injured tissues, replace the damaged struct…
View article: Impact of Micro/nanoencapsulation on the Therapeutic Outcome of Drugs
Impact of Micro/nanoencapsulation on the Therapeutic Outcome of Drugs Open
View article: Biological and Pharmacological Characterization of Ascorbic Acid and Nicotinamide Chitosan Nanoparticles against Insulin-Resistance-Induced Cognitive Defects: A Comparative Study
Biological and Pharmacological Characterization of Ascorbic Acid and Nicotinamide Chitosan Nanoparticles against Insulin-Resistance-Induced Cognitive Defects: A Comparative Study Open
High consumption of industrialized food with high fat content is generally associated with insulin resistance, which in turn causes memory impairment and cognitive decline. Nicotinamide and ascorbic acid are among the promising neuroprotec…
View article: Coenzyme Q10 phospholipidic vesicular formulations for treatment of androgenic alopecia: <i>ex vivo</i> permeation and clinical appraisal
Coenzyme Q10 phospholipidic vesicular formulations for treatment of androgenic alopecia: <i>ex vivo</i> permeation and clinical appraisal Open
Coenzyme Q10 (CoQ10) is an antioxidant molecule with anti-aging activity on human hair, and because of its pharmaceutical limitations such as large molecular weight, high lipophilicity and poor water solubility, its therapeutic effectivene…