Uma Mahadevan
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View article: Pregnancy Outcomes After Maternal or Paternal Exposure to Tofacitinib Across Clinical Programs
Pregnancy Outcomes After Maternal or Paternal Exposure to Tofacitinib Across Clinical Programs Open
INTRODUCTION: This analysis reports updated pregnancy outcomes after tofacitinib exposure in patients with immune-mediated diseases. METHODS: Pregnancy/partner pregnancy cases from interventional studies were identified in Pfizer safety da…
View article: IBD 2024: Charting a New Course in IBD Proceedings of the Takeda Symposium 22–23 November 2024 W Hotel, Brisbane, Queensland, Australia
IBD 2024: Charting a New Course in IBD Proceedings of the Takeda Symposium 22–23 November 2024 W Hotel, Brisbane, Queensland, Australia Open
The symposium IBD 2024: Charting a New Course in IBD was held in Brisbane, Australia, in November 2024. This was the fifth such meeting for the Australian inflammatory bowel disease (IBD) healthcare community. This symposium provided an ov…
View article: From nanoparticles to robotic pills: The evolution of nanotechnology in drug delivery
From nanoparticles to robotic pills: The evolution of nanotechnology in drug delivery Open
By allowing exact, targeted, and patient-centric treatments, nanotechnology has revolutionized drug delivery systems (DDSs). This paper tracks the evolution from passive nanoparticles (1980s) to active nanorobots and robotic pills, describ…
View article: The silent revolution in drug delivery: Exploring the extraordinary potential of nanosponges in modern medicine
The silent revolution in drug delivery: Exploring the extraordinary potential of nanosponges in modern medicine Open
Nanosponges are a new class of smart drug carriers with great promise in improving drug delivery. These tiny, sponge-like particles are made by crosslinking polymers such as cyclodextrins, creating a porous structure that can hold a variet…
View article: Analytical Method Development and Validation for the Estimation of Nicotine Content in Various Tobacco Grades by RP-HPLC
Analytical Method Development and Validation for the Estimation of Nicotine Content in Various Tobacco Grades by RP-HPLC Open
A simple, precise, rapid, selective, and economic reversed phase high- performance liquid chromatography (RP-HPLC) method has been developed and validated for the estimation of nicotine content in various tobacco grades in laboratory prepa…
View article: Single-cell spatial transcriptomics of fixed, paraffin-embedded biopsies reveals colitis-associated cell networks
Single-cell spatial transcriptomics of fixed, paraffin-embedded biopsies reveals colitis-associated cell networks Open
Background & Aims Imaging-based, single-cell spatial transcriptomics (iSCST) using formalin-fixed, paraffin-embedded (FFPE) tissue could transform translational research by retaining all tissue cell subsets and spatial locations while enab…
View article: Correlation between kinesiophobia and pain in people with knee osteoarthritis: A cross-sectional pilot study
Correlation between kinesiophobia and pain in people with knee osteoarthritis: A cross-sectional pilot study Open
Objectives: Osteoarthritis (OA) is a degenerative joint disease that impacts articular cartilage. As people age, OA becomes a more common major public health issue. The study’s goal was to determine how kinesiophobia, pain severity, and pa…
View article: Extended Monitoring for Transition to Oral Corticosteroids in Acute Severe Ulcerative Colitis May Be Unnecessarily Prolonging Length of Stay
Extended Monitoring for Transition to Oral Corticosteroids in Acute Severe Ulcerative Colitis May Be Unnecessarily Prolonging Length of Stay Open
View article: Prevalence of Malnutrition and Micronutrient Deficiencies in Older Adults with Ulcerative Colitis
Prevalence of Malnutrition and Micronutrient Deficiencies in Older Adults with Ulcerative Colitis Open
Background and Aims: The nutritional status and consequences of malnutrition among older adults with ulcerative colitis (UC) is not known. Methods: We conducted a single-center, retrospective study of patients 65 years and older with Ulcer…
View article: Pregnancy Outcomes in Patients Treated with Upadacitinib: Analysis of Data from Clinical Trials and Postmarketing Reports
Pregnancy Outcomes in Patients Treated with Upadacitinib: Analysis of Data from Clinical Trials and Postmarketing Reports Open
As the data are limited for in utero exposure to upadacitinib, definitive conclusions cannot be drawn regarding the effect of upadacitinib on pregnancy outcomes. Rates of adverse pregnancy outcomes with upadacitinib exposure were comparabl…
View article: A Review on Therapeutic Potential of <i>Rosmarinus officinalis</i> L
A Review on Therapeutic Potential of <i>Rosmarinus officinalis</i> L Open
Rosemary (Rosmarinus officinalis L.) is an aromatic evergreen shrub with a long history of culinary and medicinal applications. This review aims to provide a comprehensive overview of the therapeutic potential of rosemary and its bioactive…
View article: Unexpected Finding on Endoscopy Done for Evaluation of Dyspepsia—GI Melanoma
Unexpected Finding on Endoscopy Done for Evaluation of Dyspepsia—GI Melanoma Open
Background: Malignant melanoma (MM) is the most common carcinoma to metastasize to the gastrointestinal (GI) tract and it carries a poor prognosis.1 The primary is usually the skin [extremities (15–57%) followed by the trunk (13–54%) and h…
View article: Pregnancy Outcomes in the Ozanimod Clinical Development Program in Patients With Ulcerative Colitis, Crohn’s Disease, and Relapsing Multiple Sclerosis
Pregnancy Outcomes in the Ozanimod Clinical Development Program in Patients With Ulcerative Colitis, Crohn’s Disease, and Relapsing Multiple Sclerosis Open
Lay Summary This study evaluated pregnancy outcomes in patients with ulcerative colitis, Crohn’s disease, or multiple sclerosis and in healthy volunteers treated with ozanimod. There was no increased incidence of fetal abnormalities or adv…
View article: P956 Pregnancy outcomes after maternal or paternal exposure in the tofacitinib ulcerative colitis clinical programme
P956 Pregnancy outcomes after maternal or paternal exposure in the tofacitinib ulcerative colitis clinical programme Open
Background Pregnant women with ulcerative colitis (UC) have a higher risk of adverse pregnancy outcomes vs age-matched controls.1 Tofacitinib is an oral Janus kinase inhibitor for the treatment of UC. There are no well-controlled studies o…
View article: Surgery for Crohn’s Disease Is Associated With a Dysbiotic Microbiome and Metabolome: Results From Two Prospective Cohorts
Surgery for Crohn’s Disease Is Associated With a Dysbiotic Microbiome and Metabolome: Results From Two Prospective Cohorts Open
In 2 different populations, prior surgery in Crohn's disease is associated with altered fecal microbiome. Patients who had undergone ileal resection had reduction in the potentially beneficial bacteria E lenta and related actinobacteria an…
View article: Single-Cell Spatial Transcriptomics of Fixed, Paraffin-Embedded Biopsies Reveals Colitis-Associated Cell Networks
Single-Cell Spatial Transcriptomics of Fixed, Paraffin-Embedded Biopsies Reveals Colitis-Associated Cell Networks Open
View article: P1141 Global perspectives on managing Inflammatory Bowel Disease (IBD) during pregnancy and lactation: current state and the necessity for enhancements
P1141 Global perspectives on managing Inflammatory Bowel Disease (IBD) during pregnancy and lactation: current state and the necessity for enhancements Open
Background Reproduction is an essential part of life. Our aim was to obtain a global perspective on IBD management by gastroenterologists (GIs) during preconception, pregnancy, lactation and neonatal period. Methods An anonymous survey (75…
View article: Evaluation of the Effect of Pollution on the Level of Antioxidant Enzymes in Freshwater Fishes
Evaluation of the Effect of Pollution on the Level of Antioxidant Enzymes in Freshwater Fishes Open
To assess the impact of polluted water on fishes, biochemical studies were carried out to determine the biochemical alterations in tissues of fishes collected from the control and upstream, midstream and downstream sites of the Varahanadhi…
View article: Maternal and Neonatal Outcomes in Vedolizumab- and Ustekinumab-Exposed Pregnancies: Results From the PIANO Registry
Maternal and Neonatal Outcomes in Vedolizumab- and Ustekinumab-Exposed Pregnancies: Results From the PIANO Registry Open
Background: Pregnancy outcomes in patients with inflammatory bowel disease with quiescent disease are similar to those in the general population. Data from the Pregnancy Inflammatory bowel disease And Neonatal Outcomes registry have demons…
View article: Small Beginnings, Big Learnings
Small Beginnings, Big Learnings Open
View article: A Digital Health Intervention to Improve the Clinical Care of Inflammatory Bowel Disease Patients
A Digital Health Intervention to Improve the Clinical Care of Inflammatory Bowel Disease Patients Open
Background Inflammatory bowel disease (IBD) is a chronic condition that requires close monitoring. Digital health virtual care platforms can enable self-monitoring and allow providers to remotely surveil patients and efficiently identify t…
View article: Assessing the Impact of COVID-19 on IBD Outcomes Among Vulnerable Patient Populations in a Large Metropolitan Center
Assessing the Impact of COVID-19 on IBD Outcomes Among Vulnerable Patient Populations in a Large Metropolitan Center Open
BACKGROUND With the onset of COVID-19, there were rapid changes in healthcare delivery as remote access became the norm. The aim of this study was to determine the impact of changes in healthcare delivery during the COVID-19 pandemic on pa…
View article: A Rare Case of Ileal Mucosa associated Lymphoid Tissue-MALT Lymphoma
A Rare Case of Ileal Mucosa associated Lymphoid Tissue-MALT Lymphoma Open
View article: Comparative Safety and Effectiveness of Biologic Therapy for Crohn’s Disease: A CA-IBD Cohort Study
Comparative Safety and Effectiveness of Biologic Therapy for Crohn’s Disease: A CA-IBD Cohort Study Open
View article: Effectiveness and Safety of Biologic Therapy in Hispanic Vs Non-Hispanic Patients With Inflammatory Bowel Diseases: A CA-IBD Cohort Study
Effectiveness and Safety of Biologic Therapy in Hispanic Vs Non-Hispanic Patients With Inflammatory Bowel Diseases: A CA-IBD Cohort Study Open
View article: Pregnancy outcomes following periconceptional or gestational exposure to ustekinumab: Review of cases reported to the manufacturer's global safety database
Pregnancy outcomes following periconceptional or gestational exposure to ustekinumab: Review of cases reported to the manufacturer's global safety database Open
Summary Background Ustekinumab, a human immunoglobulin G1 monoclonal antibody that binds to and inhibits interleukin (IL)‐12/IL‐23, is indicated for multiple immune‐mediated diseases. Ustekinumab is actively transported across the placenta…
View article: 613 PATERNAL EXPOSURE TO IMMUNOSUPPRESSIVE AND/OR BIOLOGIC AGENTS AND BIRTH OUTCOMES IN PATIENTS WITH IMMUNE-MEDIATED INFLAMMATORY DISEASES
613 PATERNAL EXPOSURE TO IMMUNOSUPPRESSIVE AND/OR BIOLOGIC AGENTS AND BIRTH OUTCOMES IN PATIENTS WITH IMMUNE-MEDIATED INFLAMMATORY DISEASES Open
View article: Paternal Exposure to Immunosuppressive and/or Biologic Agents and Birth Outcomes in Patients With Immune-Mediated Inflammatory Diseases
Paternal Exposure to Immunosuppressive and/or Biologic Agents and Birth Outcomes in Patients With Immune-Mediated Inflammatory Diseases Open
View article: Overview of Pregnancy in Patients With Inflammatory Bowel Disease.
Overview of Pregnancy in Patients With Inflammatory Bowel Disease. Open
View article: Pregnancy and Neonatal Outcomes After Fetal Exposure to Biologics and Thiopurines Among Women With Inflammatory Bowel Disease
Pregnancy and Neonatal Outcomes After Fetal Exposure to Biologics and Thiopurines Among Women With Inflammatory Bowel Disease Open