Mahanjit Konwar
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View article: Impact of Disease-Modifying Therapies on MRI Outcomes in Patients with Relapsing -Remitting Multiple Sclerosis: A Systematic Review and Network Meta-Analysis
Impact of Disease-Modifying Therapies on MRI Outcomes in Patients with Relapsing -Remitting Multiple Sclerosis: A Systematic Review and Network Meta-Analysis Open
Background Multiple sclerosis is a chronic autoimmune inflammatory demyelinating disorder of the central nervous system. The clinical presentation supported by characteristic findings on MRI forms the backbone of the current diagnostic cri…
View article: Vitamin D deficiency in rheumatoid arthritis patients of India – a single-arm meta-analysis
Vitamin D deficiency in rheumatoid arthritis patients of India – a single-arm meta-analysis Open
Background: Vitamin D deficiency is commonly seen in patients with rheumatoid arthritis (RA).
Objectives: This meta-analysis is aimed to determine the prevalence of Vitamin D deficiency in RA patients in India and also to evaluate the ass…
View article: Impact of sodium-glucose co-transporter 2 inhibitors on renal outcomes in patients of diabetes mellitus
Impact of sodium-glucose co-transporter 2 inhibitors on renal outcomes in patients of diabetes mellitus Open
Sodium-glucose co-transporter 2 inhibitors (SGLT2is) are recommended as the next step therapy for the management of diabetes mellitus. The large clinical trials of SGLT2is demonstrated benefits on various renal endpoints. We conducted this…
View article: Efficacy and Safety of Liraglutide 3.0 mg in Patients with Overweight and Obese with or without Diabetes: A Systematic Review and Meta‐Analysis
Efficacy and Safety of Liraglutide 3.0 mg in Patients with Overweight and Obese with or without Diabetes: A Systematic Review and Meta‐Analysis Open
Background . Liraglutide in a 3.0 mg subcutaneous dose daily is approved for weight reduction. Objectives . Objectives are to evaluate the efficacy and safety of liraglutide 3.0 mg in patients with overweight and obesity irrespective of di…
View article: An audit of safety reporting in randomized controlled trials over a five-year period in a high impact factor journal
An audit of safety reporting in randomized controlled trials over a five-year period in a high impact factor journal Open
Background: Randomized controlled trials [RCTs] form the corner-stone of evidence-based medicine. RCTs published in high impact factor journals such as the New England Journal of Medicine [NEJM] are a key driver of clinical practice and po…
View article: An evaluation of drug lag for new drugs approved by the Indian regulator relative to the United States, European Union, and Japanese regulatory agencies
An evaluation of drug lag for new drugs approved by the Indian regulator relative to the United States, European Union, and Japanese regulatory agencies Open
Background: The approval process of every drug regulatory agency differs, and hence, the time required for the approval of a new drug varies. This results in a drug lag and India is no exception to this phenomenon. A drug lag precludes Ind…
View article: SAT-325 ASSOCIATION OF CYP3A5 POLYMORPHISM WITH TACROLIMUS LEVELS AND GRAFT OUTCOMES IN INDIAN KIDNEY TRANSPLANT RECIPIENTS
SAT-325 ASSOCIATION OF CYP3A5 POLYMORPHISM WITH TACROLIMUS LEVELS AND GRAFT OUTCOMES IN INDIAN KIDNEY TRANSPLANT RECIPIENTS Open
Tacrolimus which is the sheet anchor of post-transplant immunosuppression has a narrow therapeutic index. It is imperative to achieve therapeutic tacrolimus levels for optimum graft survival as sub-optimal levels can predispose to graft re…
View article: The global initiative for asthma guidelines (2019): change in the recommendation for the management of mild asthma based on the SYGMA-2 trial – A critical appraisal
The global initiative for asthma guidelines (2019): change in the recommendation for the management of mild asthma based on the SYGMA-2 trial – A critical appraisal Open
The Global Initiative for Asthma (GINA) recently released their updated Global Strategy for Asthma Management and Prevention Guide (2019). The pocket guide for practicing clinicians states that "the 2019 GINA strategy report represents the…
View article: Investigator-initiated studies: Challenges and solutions
Investigator-initiated studies: Challenges and solutions Open
Investigator-initiated studies (IISs) help by generating data on effectiveness and safety of a drug in the real-world setting and attempt to answer questions that clinicians face in their day-to-day practice. These are studies that are ini…
View article: Valbenazine: Drug review
Valbenazine: Drug review Open
Valbenazine is the first drug approved by the US Food and Drug Administration for the treatment of adults with tardive dyskinesia (TD) on April 11, 2017. It acts as a reversible inhibitor of vesicular monoamine transporter 2. It is availab…
View article: A STUDY OF CLINICAL PROFILE OF ADULT PATIENTS WITH ACUTE ENCEPHALITIS SYNDROME COMING TO A TERTIARY CARE HOSPITAL OF NORTH EAST INDIA
A STUDY OF CLINICAL PROFILE OF ADULT PATIENTS WITH ACUTE ENCEPHALITIS SYNDROME COMING TO A TERTIARY CARE HOSPITAL OF NORTH EAST INDIA Open
CONTEXT
\nAcute encephalitis syndrome (AES) is a public health problem in north east India with Japanese encephalitis being a major
\naetiology. Government of India initiated an adult JE vaccination in Assam in 2011.
\nAIMS
\nWe aim to st…
View article: IN-VITRO ANTICATARACT ACTIVITY OF HIBISCUS ROSA-SINENSIS LINN ON GOAT LENS
IN-VITRO ANTICATARACT ACTIVITY OF HIBISCUS ROSA-SINENSIS LINN ON GOAT LENS Open
Objectives: To study the effects of ethanolic extract of leaves of Hibiscus rosa-sinensis Linn (EEHRS) on glucose induced cataract in an in vitro model of goat lens. Methods : Ethanolic extracts of leaves of Hibiscus rosa-sinensi…