Mahdad Noursadeghi
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View article: Temporal Dynamics of Antigen-Specific T Cell Expansion in Primary SARS-CoV-2 Infection
Temporal Dynamics of Antigen-Specific T Cell Expansion in Primary SARS-CoV-2 Infection Open
Quantifying T cell response during primary infection in humans is crucial for understanding adaptive immunity. Leveraging a controlled human challenge to SARS-CoV-2, we characterized antigen-specific T cell response within and across indiv…
View article: Single-gene transcripts for subclinical tuberculosis: an individual participant data meta-analysis
Single-gene transcripts for subclinical tuberculosis: an individual participant data meta-analysis Open
National Institute for Health Research, Wellcome Trust.
View article: Blood RNA biomarkers and C-reactive protein for triage of adult patients with tuberculosis lymphadenitis and pericarditis in South Africa: a single-centre, prospective, observational, diagnostic accuracy study
Blood RNA biomarkers and C-reactive protein for triage of adult patients with tuberculosis lymphadenitis and pericarditis in South Africa: a single-centre, prospective, observational, diagnostic accuracy study Open
South African Medical Research Council, European and Developing Countries Clinical Trials Partnership 2, National Institutes of Health/National Institute of Allergy and Infectious Diseases, Wellcome Trust, National Institute for Health and…
View article: The CSF transcriptome in adults with pneumococcal meningitis reveals compartmentalised host inflammatory responses associated with mortality
The CSF transcriptome in adults with pneumococcal meningitis reveals compartmentalised host inflammatory responses associated with mortality Open
Pneumococcal meningitis (PM) has persistently poor clinical outcomes, especially in sub-Saharan Africa. To better characterise the inflammatory response and identify factors associated with mortality we compared paired peripheral blood and…
View article: Longitudinal kinetics of the viral infection biomarker 3′-deoxy-3′,4′-didehydro-cytidine in SARS-CoV-2, influenza A virus and RSV human challenge models
Longitudinal kinetics of the viral infection biomarker 3′-deoxy-3′,4′-didehydro-cytidine in SARS-CoV-2, influenza A virus and RSV human challenge models Open
3’-deoxy-3’,4’-didehydro-cytidine (ddhC) is a recently discovered host biomarker for viral infections, though its temporal kinetics remain unclear. This study tests the hypothesis that ddhC is an acute phase reactant, rising shortly after …
View article: Type I interferon responses contribute to immune protection against mycobacterial infection
Type I interferon responses contribute to immune protection against mycobacterial infection Open
Type I interferon responses have been considered detrimental to host protection in tuberculosis (TB). We provide novel data to challenge this paradigm, derived from transcriptional profiling of human in vivo immune responses to discover as…
View article: Type I interferon responses contribute to immune protection against mycobacterial infection
Type I interferon responses contribute to immune protection against mycobacterial infection Open
Type I interferon responses have been considered detrimental to host protection in tuberculosis (TB). We provide novel data to challenge this paradigm, derived from transcriptional profiling of human in vivo immune responses to discover as…
View article: Author response: Type I interferon responses contribute to immune protection against mycobacterial infection
Author response: Type I interferon responses contribute to immune protection against mycobacterial infection Open
View article: Evolution of T cell responses in the tuberculin skin test reveals generalisable Mtb-reactive T cell metaclones
Evolution of T cell responses in the tuberculin skin test reveals generalisable Mtb-reactive T cell metaclones Open
T cells contribute to immune protection and pathogenesis in tuberculosis, but measurements of polyclonal responses have failed to resolve correlates of outcome. We report the first temporal evaluation of the human in vivo clonal repertoire…
View article: The tear production of tecovirimat in a single hospitalized mpox patient: a pharmacokinetic analysis
The tear production of tecovirimat in a single hospitalized mpox patient: a pharmacokinetic analysis Open
View article: Predicting trajectories of acute illness using RNA velocity of whole blood
Predicting trajectories of acute illness using RNA velocity of whole blood Open
Transcriptomic analyses reveal the status of cells, tissues, or organisms, across states of health and disease. RNA velocity adds a temporal dimension to single cell analyses, predicting future transcriptomic and phenotypic states, based o…
View article: SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections
SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections Open
View article: Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy
Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy Open
View article: Detection of <i>M. tuberculosis</i> DNA in peripheral blood mononuclear cells of tuberculosis contacts does not associate with blood RNA signatures for incipient tuberculosis
Detection of <i>M. tuberculosis</i> DNA in peripheral blood mononuclear cells of tuberculosis contacts does not associate with blood RNA signatures for incipient tuberculosis Open
Detection of M. tuberculosis DNA in TB contacts’ PBMCs does not associate with blood RNA signatures for incipient tuberculosis https://bit.ly/4dliODg
View article: Resolution of tuberculosis blood RNA signatures fails to discriminate persistent sputum culture positivity after 8 weeks of anti-tuberculous treatment
Resolution of tuberculosis blood RNA signatures fails to discriminate persistent sputum culture positivity after 8 weeks of anti-tuberculous treatment Open
Background Concerted efforts aim to reduce the burden of 6 months of anti-tuberculous treatment for tuberculosis (TB). Treatment cessation at 8 weeks is effective for most but incurs increased risk of disease relapse. We tested the hypothe…
View article: Author Correction: Human SARS-CoV-2 challenge uncovers local and systemic response dynamics
Author Correction: Human SARS-CoV-2 challenge uncovers local and systemic response dynamics Open
View article: Single-gene transcripts for subclinical TB: an individual participant data meta-analysis
Single-gene transcripts for subclinical TB: an individual participant data meta-analysis Open
Background Translation of blood RNA signatures may be accelerated by identifying more parsimonious biomarkers. We tested the hypothesis that single-gene transcripts provide comparable accuracy for detection of subclinical TB to multi-gene …
View article: Single-cell transcriptome and T cell receptor profiling of the tuberculin skin test
Single-cell transcriptome and T cell receptor profiling of the tuberculin skin test Open
The tuberculin skin test (TST) is a cutaneous delayed hypersensitivity reaction to antigen from Mycobacterium tuberculosis (Mtb). We provide the first single cell sequencing characterisation of the human TST reaction, based on skin suction…
View article: Type I interferon responses contribute to immune protection against mycobacterial infection
Type I interferon responses contribute to immune protection against mycobacterial infection Open
Type I interferon responses have been considered detrimental to host protection in tuberculosis (TB). We provide novel data to challenge this paradigm, derived from transcriptional profiling of human in vivo immune responses to discover as…
View article: Blood RNA signatures outperform CRP triage of tuberculosis lymphadenitis and pericarditis
Blood RNA signatures outperform CRP triage of tuberculosis lymphadenitis and pericarditis Open
Background Limited data are available on the diagnostic accuracy of blood RNA biomarker signatures for extrapulmonary TB (EPTB). We addressed this question among people investigated for TB lymphadenitis and TB pericarditis, in Cape Town, S…
View article: Human SARS-CoV-2 challenge uncovers local and systemic response dynamics
Human SARS-CoV-2 challenge uncovers local and systemic response dynamics Open
View article: Tribbles1 is host protective during in vivo mycobacterial infection
Tribbles1 is host protective during in vivo mycobacterial infection Open
Tuberculosis is a major global health problem and is one of the top 10 causes of death worldwide. There is a pressing need for new treatments that circumvent emerging antibiotic resistance. Mycobacterium tuberculosis parasitises macrophage…
View article: The CSF transcriptome in pneumococcal meningitis reveals compartmentalised host inflammatory responses associated with mortality
The CSF transcriptome in pneumococcal meningitis reveals compartmentalised host inflammatory responses associated with mortality Open
Background Pneumococcal meningitis (PM) has persistently poor clinical outcomes, especially in sub- Saharan Africa. To better characterise the inflammatory response and identify factors associated with mortality we compared paired peripher…
View article: Single-cell analysis of bronchoalveolar cells in inflammatory and fibrotic post-COVID lung disease
Single-cell analysis of bronchoalveolar cells in inflammatory and fibrotic post-COVID lung disease Open
Background Persistent radiological lung abnormalities are evident in many survivors of acute coronavirus disease 2019 (COVID-19). Consolidation and ground glass opacities are interpreted to indicate subacute inflammation whereas reticulati…
View article: Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses Open
International audience
View article: Point-of-care C-reactive protein and Xpert MTB/RIF Ultra for tuberculosis screening and diagnosis in unselected antiretroviral therapy initiators: a prospective, cross-sectional, diagnostic accuracy study
Point-of-care C-reactive protein and Xpert MTB/RIF Ultra for tuberculosis screening and diagnosis in unselected antiretroviral therapy initiators: a prospective, cross-sectional, diagnostic accuracy study Open
View article: Blood RNA biomarkers for tuberculosis screening in people living with HIV before antiretroviral therapy initiation: a diagnostic accuracy study
Blood RNA biomarkers for tuberculosis screening in people living with HIV before antiretroviral therapy initiation: a diagnostic accuracy study Open
South African Medical Research Council, European and Developing Countries Clinical Trials Partnership 2, National Institutes of Health National Institute of Allergy and Infectious Diseases, The Wellcome Trust, National Institute for Health…
View article: Author response: Tribbles1 is host protective during in vivo mycobacterial infection
Author response: Tribbles1 is host protective during in vivo mycobacterial infection Open
View article: Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19
Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19 Open
Background While inflammatory and immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in peripheral blood are extensively described, responses at the upper respiratory mucosal site of initial infectio…
View article: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses Open