Mahdi Mahdipour
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View article: Relationship of Body Mass Index and Dietary Inflammatory Index With Free Androgen Index and Insulin Resistance in Women With Polycystic Ovary Syndrome
Relationship of Body Mass Index and Dietary Inflammatory Index With Free Androgen Index and Insulin Resistance in Women With Polycystic Ovary Syndrome Open
Background: Polycystic ovary syndrome (PCOS) is a leading endocrine disorder in reproductive-aged women. While dietary interventions are widely advocated, the distinct roles of adiposity and dietary inflammation in driving PCOS phenotypes …
View article: Chemical characterization, antibacterial, and antiproliferative bioactivities of natural melanin-based quantum dots from Aplysia dactylomela sea hare ink
Chemical characterization, antibacterial, and antiproliferative bioactivities of natural melanin-based quantum dots from Aplysia dactylomela sea hare ink Open
This study focused on the extraction, isolation, and characterization of natural melanin-based quantum dots (NMQDs) derived from the ink of the sea hare Aplysia dactylomela , with an evaluation of their antibacterial and anticancer propert…
View article: Strain-dependent effects of Toxoplasma gondii on ovarian health and inflammation in a rat model
Strain-dependent effects of Toxoplasma gondii on ovarian health and inflammation in a rat model Open
Toxoplasma gondii, an obligatory intracellular parasite, is the causative agent of toxoplasmosis, a widespread disease affecting approximately one-third of the global population. This study investigates the strain-specific effects of T. go…
View article: Uncovering Novel Anti-Lung Cancer Compounds: Insights from Marine Sponge-Derived Agents: A Bibliometric Review.
Uncovering Novel Anti-Lung Cancer Compounds: Insights from Marine Sponge-Derived Agents: A Bibliometric Review. Open
This study highlights the potential of alkaloids and sesquiterpenes derived from marine sponges as promising anti-lung cancer agents, emphasizing the need for further in vitro, in vivo, and clinical investigations to validate…
View article: Advances in stem cell therapy for erectile dysfunction: preclinical evidence and emerging therapeutic approaches
Advances in stem cell therapy for erectile dysfunction: preclinical evidence and emerging therapeutic approaches Open
The inability to get or sustain an erection strong enough for fulfilling sexual performance is the hallmark of the common disorder known as erectile dysfunction (ED). It mostly affects a significant percentage of men worldwide, particularl…
View article: Different storage and freezing protocols for extracellular vesicles: a systematic review
Different storage and freezing protocols for extracellular vesicles: a systematic review Open
View article: Ceratonia siliqua L. pod Effects on Viability Gene Expression of Endometrial Mesenchymal Stromal/Stem Cells Isolated from Women with Endometriosis-Associated Infertility.
Ceratonia siliqua L. pod Effects on Viability Gene Expression of Endometrial Mesenchymal Stromal/Stem Cells Isolated from Women with Endometriosis-Associated Infertility. Open
In vitro and in silico analyses of CPE bioactive compounds show that they may downregulate the cell inflammatory pathway involved in the pathophysiology of endometriosis.
View article: Toxic effects of plastic particles on cardiovascular system and angiogenesis potential: a major challenge of the current century
Toxic effects of plastic particles on cardiovascular system and angiogenesis potential: a major challenge of the current century Open
Background. In recent years, plastic waste and residuals in different ecosystems have been introduced as serious challenges. Plastics with different chemical structures and derivatives are extensively applied for the packing of foods, phar…
View article: WITHDRAWN: Endometriosis related sex steroid hormones, hypothalamic pituitary gonadal axis hormones and related animal modeling: A comprehensive review of published articles and endometriosis induction methods from 2010 to 2021 with scoring based approach
WITHDRAWN: Endometriosis related sex steroid hormones, hypothalamic pituitary gonadal axis hormones and related animal modeling: A comprehensive review of published articles and endometriosis induction methods from 2010 to 2021 with scoring based approach Open
The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
View article: Bone Marrow and Peripheral Blood Mononuclear Cell Phenotype Changes after Cultivation and Autologous Infusion in Patients with Primary Biliary Cholangitis.
Bone Marrow and Peripheral Blood Mononuclear Cell Phenotype Changes after Cultivation and Autologous Infusion in Patients with Primary Biliary Cholangitis. Open
In summary, our study shows that BM-MNC transplantation in PBC patients leads to changes in immune cell populations and liver function. These findings suggest potential therapeutic applications of BM-MNC transplantation in managing PBC and…
View article: Correction: Amniotic fluid-derived exosomes attenuated fibrotic changes in POI rats through modulation of the TGF-β/Smads signaling pathway
Correction: Amniotic fluid-derived exosomes attenuated fibrotic changes in POI rats through modulation of the TGF-β/Smads signaling pathway Open
View article: Ultrasound-assisted encapsulating folic acid-based carbon quantum dots within breast cancer cell-derived exosomes as a co-receptors-mediated anticancer nanocarrier for enhanced breast cancer therapy
Ultrasound-assisted encapsulating folic acid-based carbon quantum dots within breast cancer cell-derived exosomes as a co-receptors-mediated anticancer nanocarrier for enhanced breast cancer therapy Open
View article: Improving Fertility in Non-obstructive Azoospermia: Results from an Autologous Bone Mar-row-Derived Mesenchymal Stromal/Stem Cell Phase I Clinical Trial.
Improving Fertility in Non-obstructive Azoospermia: Results from an Autologous Bone Mar-row-Derived Mesenchymal Stromal/Stem Cell Phase I Clinical Trial. Open
Autotransplantation of BM-MSCs into the testicular network using microTESE in NOA patients led to the regeneration of seminiferous tubules and the regulation of hormonal profiles governing spermatogenesis. Our findings support the safety a…
View article: Identification of key pathways and molecular players potentially involved in endometrial cancer metastasis through integrated bioinformatics analyses
Identification of key pathways and molecular players potentially involved in endometrial cancer metastasis through integrated bioinformatics analyses Open
Introduction: Endometrial cancer (EC) is a particularly frequent gynecological cancer, and metastasis is the leading cause of death in patients with EC. Using publicly accessible gene expression data, a bioinformatics study was carried out…
View article: Direct profiling of breast cancer-derived extracellular vesicles using Pd-perovskite electrochemical biosensing platform
Direct profiling of breast cancer-derived extracellular vesicles using Pd-perovskite electrochemical biosensing platform Open
Extracellular vesicles (EVs) harbor several signaling molecules to maintain intercellular communication. Based on the exosomal cargo type, metabolic, genomic, and proteomic status of parent cells can be investigated. Due to the existence o…
View article: Proliferating and migrating effects of regenerating sea anemone <i>Aulactinia stella</i> cells-derived exosomes on human skin fibroblasts
Proliferating and migrating effects of regenerating sea anemone <i>Aulactinia stella</i> cells-derived exosomes on human skin fibroblasts Open
Regenerative effects of sea anemone-derived exosomes on human foreskin fibroblasts (HFFs) were investigated. Water-based extracts from regenerating Aulactinia stella tissue were collected at various time points, and exosomes were ex…
View article: Engineering of ovarian tissue for ovarian dysfunctions: A review
Engineering of ovarian tissue for ovarian dysfunctions: A review Open
This review explores tissue engineering as a potential solution for reproductive health issues in women caused by genetic or acquired diseases, such as premature ovarian failure or oophorectomy. The loss of ovarian function can lead to inf…
View article: Anti-lung cancer compounds derived from marine sponges: in-silico, pharmacological and bibliometric analyses
Anti-lung cancer compounds derived from marine sponges: in-silico, pharmacological and bibliometric analyses Open
Lung cancer remains a leading cause of cancer-related mortality, necessitating improved treatment strategies. Consequently, researchers have focused on the development of novel anti-lung cancer agents in recent decades. Marine sponges have…
View article: Proliferating and migrating effects of regenerating sea anemone Aulactinia stella cells- derived exosomes on human skin fibroblasts
Proliferating and migrating effects of regenerating sea anemone Aulactinia stella cells- derived exosomes on human skin fibroblasts Open
This study evaluated the possible regenerative effects of proliferating sea anemone cells-derived exosomes on human foreskin fibroblasts (HFF). Water-based extracts from sea anemone Aulactinia stella tissue 48 h after regeneration was coll…
View article: Xenogeneic Transplantation Promoted Human Exosome Sequestration in Rat Specific Organs
Xenogeneic Transplantation Promoted Human Exosome Sequestration in Rat Specific Organs Open
Purpose: Here, we aimed to study the distribution pattern of normal and cancer xenogeneic exosomes (Exos) and possible interspecies reactions in a rat model. Methods: Exos were isolated from normal Human umbilical vein endothelial cells (H…
View article: Synergistic effect of chitosan-alginate composite hydrogel enriched with ascorbic acid and alpha-tocopherol under hypoxic conditions on the behavior of mesenchymal stem cells for wound healing
Synergistic effect of chitosan-alginate composite hydrogel enriched with ascorbic acid and alpha-tocopherol under hypoxic conditions on the behavior of mesenchymal stem cells for wound healing Open
View article: Microbial Landscape and Antibiotic-Susceptibility Profiles of Microorganisms in Patients with Bacterial Pneumonia: A Comparative Cross-Sectional Study of COVID-19 and Non-COVID-19 Cases in Aktobe, Kazakhstan
Microbial Landscape and Antibiotic-Susceptibility Profiles of Microorganisms in Patients with Bacterial Pneumonia: A Comparative Cross-Sectional Study of COVID-19 and Non-COVID-19 Cases in Aktobe, Kazakhstan Open
This cross-sectional study investigated the microbial landscape and antibiotic-resistance patterns in patients with bacterial pneumonia, with a focus on the impact of COVID-19. Sputum samples from individuals with bacterial pneumonia, incl…
View article: Comparison the therapeutic effects of bone marrow CD144<sup>+</sup> endothelial cells and CD146<sup>+</sup> mesenchymal stem cells in POF rats
Comparison the therapeutic effects of bone marrow CD144<sup>+</sup> endothelial cells and CD146<sup>+</sup> mesenchymal stem cells in POF rats Open
Introduction: Premature ovarian insufficiency (POI) is a challenging issue in terms of reproduction biology. In this study, therapeutic properties of bone marrow CD146+ mesenchymal stem cells (MSCs) and CD144+ endothelial cells (ECs) were …
View article: Amniotic fluid-derived exosomes attenuated fibrotic changes in POI rats through modulation of the TGF-β/Smads signaling pathway
Amniotic fluid-derived exosomes attenuated fibrotic changes in POI rats through modulation of the TGF-β/Smads signaling pathway Open
In the current study, we investigated the regenerative effects of amniotic fluid exosomes (AF-Exos) in a rat model for premature ovarian insufficiency (POI). POI is a condition characterized by a decrease in ovarian function that can lead …
View article: Melatonin blunted the angiogenic activity in 3D colon cancer tumoroids by the reduction of endocan
Melatonin blunted the angiogenic activity in 3D colon cancer tumoroids by the reduction of endocan Open
View article: Interaction of lncRNAs with mTOR in colorectal cancer: a systematic review
Interaction of lncRNAs with mTOR in colorectal cancer: a systematic review Open
View article: Early stage evaluation of cancer stem cells using platinum nanoparticles/CD133+ enhanced nanobiocomposite
Early stage evaluation of cancer stem cells using platinum nanoparticles/CD133+ enhanced nanobiocomposite Open
Background Cancer stem cells (CSCs) are of great diagnostic importance due to their involvement in tumorigenesis, therapeutic resistance, metastasis and relapse. Method In this work, a sensitive electrochemical cytosensor was successfully …
View article: A Bibliometric and In Silico-Based Analysis of Anti-Lung Cancer Compounds from Sea Cucumber
A Bibliometric and In Silico-Based Analysis of Anti-Lung Cancer Compounds from Sea Cucumber Open
Lung cancer is one of the most lethal malignancies in the world. However, current curative approaches for treating this type of cancer have some weaknesses. Therefore, scientists are attempting to discover new anti-lung cancer agents. Sea …
View article: A Comprehensive Overview of Innovative Approaches to Prevent Kidney Ischemia-Reperfusion Injury: Bibliometric and In Silico Analyses
A Comprehensive Overview of Innovative Approaches to Prevent Kidney Ischemia-Reperfusion Injury: Bibliometric and In Silico Analyses Open
Ischemia-reperfusion injury (IRI) is a complex pathophysiological process that can lead to severe and irreversible consequences, including the complete loss of renal function. While standardized strategies for preventing IRI during "b…
View article: Melatonin and endothelial cell-loaded alginate-fibrin hydrogel promoted angiogenesis in rat cryopreserved/thawed ovaries transplanted to the heterotopic sites
Melatonin and endothelial cell-loaded alginate-fibrin hydrogel promoted angiogenesis in rat cryopreserved/thawed ovaries transplanted to the heterotopic sites Open
Background Ischemic niche can promote follicular atresia following the transplantation of cryopreserved/thawed ovaries to the heterotopic sites. Thus, the promotion of blood supply is an effective strategy to inhibit/reduce the ischemic da…