Explanipedia

Quantitative Pharmacology Methods for Bispecific T Cell Engagers Open

Mahdiar Sadeghi, Irina Kareva, Gleb Pogudin, Eduardo D. Sontag · 2025

T Cell Engager (TCE)s are an exciting therapeutic modality in immuno-oncology that acts to bypass antigen presentation and forms a direct link between cancer and immune cells in the Tumor Microenvironment (TME). TCEs are efficacious only w…

Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration Open

Sean K. Ryan, Matija Zelic, Yingnan Han, Erin Teeple, Luoman Chen , et al. · 2022

Model-based decision making in life sciences Open

Mahdiar Sadeghi · 2022

Mathematical models are key tools in rational decision-making processes. A ``good" model is expected to reproduce experimental observations, which enables predictions outside the previous experimental settings. The accuracy of predictions …

Microglia ferroptosis is prevalent in neurodegenerative disease and regulated by SEC24B Open

Sean K. Ryan, Matija Zelic, Yingnan Han, Erin Teeple, Luoman Chen , et al. · 2021

Iron dysregulation has been implicated in multiple neurodegenerative diseases, including Parkinson’s Disease (PD), Amyotrophic Lateral Sclerosis (ALS), and Multiple Sclerosis (MS). One prominent feature of affected brain regions are iron-l…

Long-Term Regulation of Prolonged Epidemic Outbreaks in Large Populations via Adaptive Control: A Singular Perturbation Approach Open

M. Ali Al-Radhawi, Mahdiar Sadeghi, Eduardo D. Sontag · 2021

Initial hopes of quickly eradicating the COVID-19 pandemic proved futile, and the goal shifted to controlling the peak of the infection, so as to minimize the load on healthcare systems. To that end, public health authorities intervened ag…

Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource Open

Hirotaka Iwaki, Hampton L. Leonard, Mary B. Makarious, Matt Bookman, Barry Landin , et al. · 2021

Background Whole‐genome sequencing data are available from several large studies across a variety of diseases and traits. However, massive storage and computation resources are required to use these data, and to achieve sufficient power fo…

Long-term regulation of prolonged epidemic outbreaks in large\n populations via adaptive control: a singular perturbation approach Open

M. Ali Al-Radhawi, Mahdiar Sadeghi, Eduardo D. Sontag · 2021

Initial hopes of quickly eradicating the COVID-19 pandemic proved futile, and\nthe goal shifted to controlling the peak of the infection, so as to minimize\nthe load on healthcare systems. To that end, public health authorities\nintervened…

Universal features of epidemic models under social distancing guidelines Open

Mahdiar Sadeghi, James M. Greene, Eduardo D. Sontag · 2021

Accelerating Medicines Partnership: Parkinson’s Disease. Genetic Resource Open

Hirotaka Iwaki, Hampton L. Leonard, Mary B. Makarious, Matt Bookman, Barry Landin , et al. · 2020

Background Whole-genome sequencing (WGS) data is available from several large studies across a variety of diseases and traits. However, massive storage and computation resources are required to use these data, and, to achieve the sufficien…

Genome-Wide Polygenic Risk Score Identifies Individuals at Elevated Parkinson’s Disease Risk Open

Yingnan Han, Erin Teeple, Srinivas Shankara, Mahdiar Sadeghi, Cheng Zhu , et al. · 2020

SUMMARY Parkinson’s Disease (PD) is the second most common and fastest-growing neurological disorder. Polygenic Risk Scores (PRS) using hundreds to thousands of PD-associated variants support polygenic heritability. Here, for the first tim…

Universal Features of Epidemic Models Under Social Distancing Guidelines Open

Mahdiar Sadeghi, James M. Greene, Eduardo D. Sontag · 2020

Social distancing as a form of nonpharmaceutical intervention has been enacted in many countries as a form of mitigating the spread of COVID-19. There has been a large interest in mathematical modeling to aid in the prediction of both the …

Network Analysis and Human Single Cell Brain Transcriptomics Reveal Novel Aspects of Alpha-Synuclein (SNCA) Biology Open

Erin Teeple, Khushboo Jindal, Beril Kiragasi, Siddharth Annaldasula, Annette T. Byrne , et al. · 2020

Alpha-synuclein (SNCA) aggregates are pathological hallmarks of synucleinopathies, neurodegenerative disorders including Parkinson’s Disease (PD) and Lewy Body Dementia (LBD). Functional networks are not yet well-characterized for SNCA by …

No Switching Policy Is Optimal for a Positive Linear System With a Bottleneck Entrance Open

Mahdiar Sadeghi, M. Ali Al-Radhawi, Michael Margaliot, Eduardo D. Sontag · 2019

We consider a nonlinear SISO system that is a cascade of a scalar "bottleneck entrance" and an arbitrary Hurwitz positive linear system. This system entrains i.e. in response to a $T$-periodic inflow every solution converges to a unique $T…

No Switching Policy is Optimal for a Positive Linear System with a\n Bottleneck Entrance Open

Mahdiar Sadeghi, M. Ali Al-Radhawi, Michael Margaliot, Eduardo D. Sontag · 2019

We consider a nonlinear SISO system that is a cascade of a scalar "bottleneck\nentrance" and an arbitrary Hurwitz positive linear system. This system entrains\ni.e. in response to a $T$-periodic inflow every solution converges to a unique\…

On the Periodic Gain of the Ribosome Flow Model Open

Mahdiar Sadeghi, M. Ali Al-Radhawi, Michael Margaliot, Eduardo D. Sontag · 2018

We consider a compartmental model for ribosome flow during RNA translation called the RFM. This model includes a set of positive transition rates that control the flow from every site to the consecutive site. It has been shown that when th…

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