Mahendranath Moharir
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View article: Promoting Intensive Transitions for Children and Youth with Medical Complexity from Paediatric to Adult Care: the PITCare study—protocol for a randomised controlled trial
Promoting Intensive Transitions for Children and Youth with Medical Complexity from Paediatric to Adult Care: the PITCare study—protocol for a randomised controlled trial Open
Introduction Children with medical complexity (CMC) have chronic, intensive care needs managed by many healthcare practitioners. Medical advances have enabled CMC to survive well into adulthood. However, the availability of supports as CMC…
View article: Long‐term clinical and radiological trajectories of craniocervical vasculopathy in children with <scp>PHACE</scp> syndrome
Long‐term clinical and radiological trajectories of craniocervical vasculopathy in children with <span>PHACE</span> syndrome Open
Aim To describe the rates of stroke and craniocervical vasculopathy progression in children with posterior fossa malformations, hemangioma, arterial anomalies, coarctation of the aorta/cardiac defects, and eye abnormalities (PHACE) syndrom…
View article: Building the Bridge From Pediatric to Adult Neurological Care
Building the Bridge From Pediatric to Adult Neurological Care Open
In this brief communication, we discuss the current landscape and unmet needs of pediatric to adult transition care in neurology. Optimizing transition care is a priority for patients, families, and providers with growing discussion in neu…
View article: Impact of infections on the incidence of acute inflammatory demyelinating polyneuropathy in children
Impact of infections on the incidence of acute inflammatory demyelinating polyneuropathy in children Open
Objectives Acute inflammatory demyelinating polyneuropathy (AIDP) is the leading cause of acute flaccid paralysis in children and hypothesized to be triggered by antecedent infection. We sought to determine the association between AIDP and…
View article: A Video is Worth a Thousand Words: The Use of Home Videos in Pediatric Neurology
A Video is Worth a Thousand Words: The Use of Home Videos in Pediatric Neurology Open
The use of home video recordings (HVRs) may aid in the diagnosis of neurological disorders. However, this practice remains underutilized. Through an anonymous survey, we sought to understand the perspectives of healthcare providers regardi…
View article: Multicenter Study of the Impact of COVID-19 Shelter-In-Place on Tertiary Hospital-based Care for Pediatric Neurologic Disease
Multicenter Study of the Impact of COVID-19 Shelter-In-Place on Tertiary Hospital-based Care for Pediatric Neurologic Disease Open
Objective To describe changes in hospital-based care for children with neurologic diagnoses during the initial 6 weeks following regional Coronavirus 2019 Shelter-in-Place orders. Methods This retrospective cross-sectional study of 7 US an…
View article: P.116 Cerebral Sinovenous Thrombosis in Preterm Infants
P.116 Cerebral Sinovenous Thrombosis in Preterm Infants Open
Background: Neonatal cerebral sinovenous thrombosis (CSVT) can lead to severe brain injury and long-term neurodevelopmental impairments. Previous studies of neonatal CSVT have mainly included term infants. In this study, we examined the cl…
View article: P.117 Pediatric acute ischemic stroke protocols
P.117 Pediatric acute ischemic stroke protocols Open
Background: Approximately 1,000 children present with AIS annually in North America. Most suffer from long-term disability. Childhood AIS is diagnosed after a median of 23 hours post-symptom onset, limiting thrombolytic treatment options t…
View article: B.2 Neurologic outcome trajectory following neonatal arterial ischemic stroke (NAIS): A longitudinal observational study
B.2 Neurologic outcome trajectory following neonatal arterial ischemic stroke (NAIS): A longitudinal observational study Open
Background: Studies evaluating long-term neurologic outcomes following NAIS are scanty. We aimed to study the emergence pattern of neurologic deficits following NAIS. Methods: Neonates diagnosed with AIS were prospectively enrolled and out…
View article: 2-year-old girl with anemia and irritability
2-year-old girl with anemia and irritability Open
Journal Article 2-year-old girl with anemia and irritability Get access Vincent So, MSc, Vincent So, MSc Department of Pediatrics, School of Medicine, Queen’s University, Kingston, Ontario, CanadaQueen’s School of Medicine, Queen’s Univers…
View article: Childhood arterial ischemic stroke due to mineralizing angiopathy: an 18‐year single‐center experience
Childhood arterial ischemic stroke due to mineralizing angiopathy: an 18‐year single‐center experience Open
Mineralizing angiopathy is a unique, age‐specific stroke syndrome characterized by basal ganglia infarction and lenticulostriate calcification after minor head injury in early childhood. There is limited understanding of the pathophysiolog…
View article: Epileptogenic modulation index and synchronization in hypsarrhythmia of West syndrome secondary to perinatal arterial ischemic stroke
Epileptogenic modulation index and synchronization in hypsarrhythmia of West syndrome secondary to perinatal arterial ischemic stroke Open
Epileptogenic cortical-subcortical transcallosal networks from affected hemisphere post-PAIS provokes infantile spasms.
View article: Long‐term cognitive outcomes after cerebral sinovenous thrombosis in childhood
Long‐term cognitive outcomes after cerebral sinovenous thrombosis in childhood Open
Aim To assess long‐term cognitive function in children after cerebral sinovenous thrombosis (CSVT). Method Children with CSVT, who had neuropsychological testing for intellectual ability, executive function, attention, language, or behavio…
View article: Predicting Ischemic Risk Using Blood Oxygen Level–Dependent MRI in Children with Moyamoya
Predicting Ischemic Risk Using Blood Oxygen Level–Dependent MRI in Children with Moyamoya Open
Our study demonstrates that idiopathic moyamoya and the presence of steal are independently associated with ischemic events. The use of blood oxygen level-dependent cerebrovascular reactivity could potentially assist in the selection of pa…
View article: The epileptology of GNB5 encephalopathy
The epileptology of GNB5 encephalopathy Open
Pathogenic variants in GNB5 cause an autosomal recessive neurodevelopmental disorder with neonatal sinus bradycardia. Seizures or epilepsy occurred in 10 of 22 previously reported cases, including 6 children from one family. We delineate t…
View article: Recurrent stroke: the role of thrombophilia in a large international pediatric stroke population
Recurrent stroke: the role of thrombophilia in a large international pediatric stroke population Open
In the article pre-published online on January 24, 2019 and published in the paper version of Haematologica [volume 104(8):1676-1681; doi:10.3324/haematol2018.211433] we have to correct: • that recurrent stroke occurred in 160/872 (instead…
View article: CJN volume 46 issue S1 Cover and Front matter
CJN volume 46 issue S1 Cover and Front matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Recurrent stroke: the role of thrombophilia in a large international pediatric stroke population
Recurrent stroke: the role of thrombophilia in a large international pediatric stroke population Open
Risk factors for arterial ischemic stroke in children include vasculopathy and prothrombotic risk factors but their relative importance to recurrent stroke is uncertain. Data on recurrent stroke from databases held in Canada (Toronto), Ger…
View article: Anatomical Venous Variants in Children With Cerebral Sinovenous Thrombosis
Anatomical Venous Variants in Children With Cerebral Sinovenous Thrombosis Open
Background and Purpose— Literature is sparse on the frequency and significance of anatomical venous variants (AVVs) in pediatric cerebral sinovenous thrombosis (CSVT). Methods— We retrospectively reviewed children with CSVT and controls un…
View article: Feeding and swallowing impairment in children with stroke and unilateral cerebral palsy: a systematic review
Feeding and swallowing impairment in children with stroke and unilateral cerebral palsy: a systematic review Open
Aim This systematic review targeted frequency estimates of dysphagia (feeding and swallowing problems), related health outcomes, and caregiver burden in children with stroke or unilateral cerebral palsy ( CP ). Method Six electronic databa…
View article: Child Neurology: Mimics of cerebral sinovenous thrombosis
Child Neurology: Mimics of cerebral sinovenous thrombosis Open
Cerebral sinovenous thrombosis (CSVT) is an uncommon but increasingly recognized condition in children because of greater clinical awareness and improvement in imaging techniques.1 Diagnosis is primarily radiologic. Clinical presentation i…
View article: Neonatal cerebral sinovenous thrombosis: the anticoagulation debate
Neonatal cerebral sinovenous thrombosis: the anticoagulation debate Open
This commentary is on the systematic review by Rossor et al. on pages 884–891 of this issue.
View article: <i>COL4A1</i> and fetal vascular origins of schizencephaly
<i>COL4A1</i> and fetal vascular origins of schizencephaly Open
Classically described by Yakovlev and Wadsworth1 in 1946, schizencephaly is a rare congenital brain malformation characterized by clefts of the cerebral mantle extending from the pial surface to lateral ventricles lined by heterotopic gray…
View article: Child Neurology: Diencephalic syndrome–like presentation of a cervicomedullary brainstem tumor
Child Neurology: Diencephalic syndrome–like presentation of a cervicomedullary brainstem tumor Open
Diencephalic syndrome is a rare clinical entity, traditionally encompassing severe failure to thrive, nystagmus, and hyperkinesis, secondary to an intracranial neoplasm that is classically located in the hypothalamic region and its vicinit…
View article: A pediatric institutional acute stroke protocol improves timely access to stroke treatment
A pediatric institutional acute stroke protocol improves timely access to stroke treatment Open
Aim We aimed to evaluate whether an institutional acute stroke protocol ( ASP ) could accelerate the diagnosis and secondary treatment of pediatric stroke. Method We initiated an ASP in 2005. We compared 209 children (125 males, 84 females…
View article: What is the Future of Pediatric Neurology in Canada? Resident and Faculty Perceptions of Training and Workforce Issues
What is the Future of Pediatric Neurology in Canada? Resident and Faculty Perceptions of Training and Workforce Issues Open
Background: Pediatric neurology trainee numbers have grown considerably in Canada; recent research, however, has shown that the number of pediatric neurology graduates is outpacing the need for future pediatric neurologists. The purpose of…
View article: Teaching Neuro <i>Images</i> : Recurrent SSPE presenting as Anton syndrome with cortical ribboning
Teaching Neuro <i>Images</i> : Recurrent SSPE presenting as Anton syndrome with cortical ribboning Open
A 21-year-old man, an immigrant from India who had not been vaccinated against measles in childhood, presented with new visual loss, on the background of a 4-year history of cognitive impairment due to subacute sclerosing panencephalitis (…