Mahesh Kandasamy
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View article: Intramuscular injection of therapeutic botulinum toxin facilitates blood coagulation in experimental aging mice
Intramuscular injection of therapeutic botulinum toxin facilitates blood coagulation in experimental aging mice Open
BACKGROUND Botulinum toxin (BoNT) is a bacterial poison that acts by blocking the release of acetylcholine-containing vesicles at the neuromuscular junction. Notably, a mild amount of BoNT is known to exert therapeutic benefits against var…
View article: Heart-brain axis, gliotransmitters and peripheral neurogenesis: Emerging regenerative roles of cardiac nexus glia in health and disease
Heart-brain axis, gliotransmitters and peripheral neurogenesis: Emerging regenerative roles of cardiac nexus glia in health and disease Open
The heart and brain are functionally synchronized through the heart-brain axis, also known as the neurocardiac axis. Astrocytes are the predominant subpopulation of glial cells in the central nervous system that play an integral role in ma…
View article: Therapeutic Botulinum Neurotoxin Ameliorates Motor Deficits and Anxiety, Accompanied by Dopaminergic Neuroprotection and Diminished Microglia Burden in the MPTP-Induced Mouse Model of Parkinson’s Disease
Therapeutic Botulinum Neurotoxin Ameliorates Motor Deficits and Anxiety, Accompanied by Dopaminergic Neuroprotection and Diminished Microglia Burden in the MPTP-Induced Mouse Model of Parkinson’s Disease Open
Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra (SN), leading to motor impairments and numerous non-motor manifestations, in…
View article: Resveratrol mitigates activated astrocytes and microglia preventing Alzheimer’s Disease (AD) progression and facilitates neuronal communication in Amyloid-β25–35 induced rat model for AD: A special emphasis on non-neuronal involvement in AD pathophysiology
Resveratrol mitigates activated astrocytes and microglia preventing Alzheimer’s Disease (AD) progression and facilitates neuronal communication in Amyloid-β25–35 induced rat model for AD: A special emphasis on non-neuronal involvement in AD pathophysiology Open
These findings suggest that RSV effectively reduces neuroinflammation, promotes neurogenesis in the sub granular zone of the hippocampus, and improves learning and memory in both control and AD conditions via SIRT1. This study highlights R…
View article: Theta rhythm as a real-time quantitative marker for non-invasive analysis of adult neurogenesis in the intact brain
Theta rhythm as a real-time quantitative marker for non-invasive analysis of adult neurogenesis in the intact brain Open
Background: Adult neurogenesis is a regenerative mechanism of the brain that contributes to neuroplasticity and memory consolidation. Aberrant neurogenesis is considered a key pathogenic hallmark of a wide array of neurocognitive disorders…
View article: Restoration of Memory Along With Neurogenic Enhancement by Therapeutic Botulinum Neurotoxin in a Preclinical Model of Parkinson’s Disease
Restoration of Memory Along With Neurogenic Enhancement by Therapeutic Botulinum Neurotoxin in a Preclinical Model of Parkinson’s Disease Open
Parkinson’s disease (PD) is characterized by degeneration of dopaminergic neurons in the substantia nigra (SN), leading to motor impairments, while hippocampal dysfunction contributes to memory deficits. Botulinum neurotoxin (BoNT), a ther…
View article: Plantationo(s)cenes: Creative Activism and Sri Lankan Plantation Workers
Plantationo(s)cenes: Creative Activism and Sri Lankan Plantation Workers Open
This paper describes the methods of creative activism used by a women-led plantation trade union in Sri Lanka to improve workers’ living and working conditions. We discuss how the feminist idea of “relational humility” is a vital component…
View article: Therapeutic Botulinum Neurotoxin Mitigates Anxiety-Related Symptoms, Protects Dopaminergic Neurons and Attenuates Nitric Oxide Levels in the Mptp-Injected Mouse Model of Parkinson's Disease
Therapeutic Botulinum Neurotoxin Mitigates Anxiety-Related Symptoms, Protects Dopaminergic Neurons and Attenuates Nitric Oxide Levels in the Mptp-Injected Mouse Model of Parkinson's Disease Open
View article: Aberrant Hippocampal Neuroregenerative Plasticity in Schizophrenia: Reactive Neuroblastosis as a Possible Pathocellular Mechanism of Hallucination
Aberrant Hippocampal Neuroregenerative Plasticity in Schizophrenia: Reactive Neuroblastosis as a Possible Pathocellular Mechanism of Hallucination Open
Hallucination is a sensory perception that occurs in the absence of external stimuli during abnormal neurological disturbances and various mental diseases. Hallucination is recognized as a core psychotic symptom and is particularly more pr…
View article: Cysteamine HCl Administration Impedes Motor and Olfactory Functions, Accompanied by a Reduced Number of Dopaminergic Neurons, in Experimental Mice: A Preclinical Mimetic Relevant to Parkinson’s Disease
Cysteamine HCl Administration Impedes Motor and Olfactory Functions, Accompanied by a Reduced Number of Dopaminergic Neurons, in Experimental Mice: A Preclinical Mimetic Relevant to Parkinson’s Disease Open
Cysteamine hydrochloride (Cys-HCl) has been established as a potent ulcerogenic agent of the gastrointestinal (GI) system. GI dysfunction and olfactory deficits are the most common clinical symptoms of many movement disorders, including Pa…
View article: The proneurogenic and microglial modulatory properties of botulinum toxin in the hippocampus of aging experimental mice
The proneurogenic and microglial modulatory properties of botulinum toxin in the hippocampus of aging experimental mice Open
This study explored the neurogenic and microglial modulatory properties of botulinum toxin in the hippocampus of aging experimental mice. Therapeutic botulinum toxin (BoNT) treatment is widely practiced to reduce the excessive discharge of…
View article: Cysteamine HCl Administration Impedes Motor and Olfactory Functions Accompanied by Reduced Dopaminergic Neurons in Experimental Mice: A Preclinical Mimetics Relevance to Parkinson’s Disease
Cysteamine HCl Administration Impedes Motor and Olfactory Functions Accompanied by Reduced Dopaminergic Neurons in Experimental Mice: A Preclinical Mimetics Relevance to Parkinson’s Disease Open
Cysteamine HCl has been established as a potent ulcerogenic agent of the gastrointestinal (GI) system. GI dysfunction and olfactory deficits are the most common clinical symptoms of many movement disorders including Parkinson's diseas…
View article: Low-dose aspirin increases olfactory sensitivity in association with enhanced neurogenesis and reduced activity of AChE in the experimental aging mice
Low-dose aspirin increases olfactory sensitivity in association with enhanced neurogenesis and reduced activity of AChE in the experimental aging mice Open
This study examined the effect of aspirin on olfactory discrimination and neurogenesis in experimental aging mice. The results from the buried food test (BFT) and odour preference test (OPT) indicated that aspirin treatment enhanced the ol…
View article: Aberrant Hippocampal Neuroregenerative Plasticity in Schizophrenia: Reactive Neuroblostosis as a Possible Pathocellular Mechanism of Hallucination
Aberrant Hippocampal Neuroregenerative Plasticity in Schizophrenia: Reactive Neuroblostosis as a Possible Pathocellular Mechanism of Hallucination Open
Schizophrenia is a spectrum of neuropsychiatric deformities, characterized by hallucination, delusion, mood disorders, speech pathology, and neurocognitive deficits. Among various clinical manifestations, hallucination has been recognized …
View article: Acute Intermittent Hypoxia Therapy alters cognitive behavioral parameters in wistar albino rats
Acute Intermittent Hypoxia Therapy alters cognitive behavioral parameters in wistar albino rats Open
Cognitive disorders, including dementia and Alzheimer's disease, pose substantial global health challenges, demanding effective prevention and treatment strategies. Intermittent Hypoxia Therapy (IHT), involving brief exposures to reduced o…
View article: A Mild Dose of Aspirin Promotes Hippocampal Neurogenesis and Working Memory in Experimental Ageing Mice
A Mild Dose of Aspirin Promotes Hippocampal Neurogenesis and Working Memory in Experimental Ageing Mice Open
Aspirin has been reported to prevent memory decline in the elderly population. Adult neurogenesis in the hippocampus has been recognized as an underlying basis of learning and memory. This study investigated the effect of aspirin on spatia…
View article: Short-term intermittent hypoxia therapy promotes gliogenesis in a rat model of middle cerebral artery occlusion (MCAO) stroke
Short-term intermittent hypoxia therapy promotes gliogenesis in a rat model of middle cerebral artery occlusion (MCAO) stroke Open
Aim After focal cerebral ischemia, intermittent hypoxia therapy (IHT) could be used as a non-invasive method to stabilize and stimulate neurogenesis in the innate stem cell niche in the brain, and disrupt the glial scar around the infarct …
View article: Design and Evaluation of an Affordable Hypoxic Chamber with Comprehensive Environmental Control for Research Applications
Design and Evaluation of an Affordable Hypoxic Chamber with Comprehensive Environmental Control for Research Applications Open
Purpose In-vivo Hypoxia chamber is sought after for research on sleep apnea, among others. Recently hypoxia chambers are utilized to create intermittent hypoxia, thereby utilizing it as a treatment strategy. The commonly used Invivo hypoxi…
View article: A mild dose of aspirin promotes hippocampal neurogenesis and working memory in experimental ageing mice
A mild dose of aspirin promotes hippocampal neurogenesis and working memory in experimental ageing mice Open
Aspirin treatment is the most widely used preventive measure against cardiovascular diseases. Aspirin is also expected to provide beneficial effects on the brain. However, the association between aspirin treatment and neurocognitive functi…
View article: Pathogenomic Signature and Aberrant Neurogenic Events in Experimental Cerebral Ischemic Stroke: A Neurotranscriptomic-Based Implication for Dementia
Pathogenomic Signature and Aberrant Neurogenic Events in Experimental Cerebral Ischemic Stroke: A Neurotranscriptomic-Based Implication for Dementia Open
Background: Cerebral ischemic stroke is caused due to neurovascular damage or thrombosis, leading to neuronal dysfunction, neuroinflammation, neurodegeneration, and regenerative failure responsible for neurological deficits and dementia. T…
View article: Ranitidine Alleviates Anxiety-like Behaviors and Improves the Density of Pyramidal Neurons upon Deactivation of Microglia in the CA3 Region of the Hippocampus in a Cysteamine HCl-Induced Mouse Model of Gastrointestinal Disorder
Ranitidine Alleviates Anxiety-like Behaviors and Improves the Density of Pyramidal Neurons upon Deactivation of Microglia in the CA3 Region of the Hippocampus in a Cysteamine HCl-Induced Mouse Model of Gastrointestinal Disorder Open
Elevated levels of histamine cause over-secretion of gastric hydrochloric acid (HCl), leading to gastrointestinal (GI) disorders and anxiety. Ranitidine is an antihistamine drug widely used in the management of GI disorders, as it works by…
View article: Ranitidine Alleviates Anxiety-Like Behaviour and Improves the Density of Pyramidal Neurons upon Deactivation of Microglia in CA3 Region of the Hippocampus in A Cysteamine Hcl-Induced Mouse Model of Gastrointestinal Disorder
Ranitidine Alleviates Anxiety-Like Behaviour and Improves the Density of Pyramidal Neurons upon Deactivation of Microglia in CA3 Region of the Hippocampus in A Cysteamine Hcl-Induced Mouse Model of Gastrointestinal Disorder Open
Elevated levels of histamine cause the secretion of gastric hydrochloric acid (HCl), leading to gastrointestinal (GI) disorders and anxiety. While aberrant levels of histamine mediate neuroinflammation, pathogenic alterations in the hippoc…
View article: Intertwining Neuropathogenic Impacts of Aberrant Circadian Rhythm and Impaired Neuroregenerative Plasticity in Huntington’s Disease: Neurotherapeutic Significance of Chemogenetics
Intertwining Neuropathogenic Impacts of Aberrant Circadian Rhythm and Impaired Neuroregenerative Plasticity in Huntington’s Disease: Neurotherapeutic Significance of Chemogenetics Open
Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by abnormal progressive involuntary movements, cognitive deficits, sleep disturbances, and psychiatric symptoms. The onset and progression of the clinical …
View article: Resveratrol Mediated Regulation of Hippocampal Neuroregenerative Plasticity via SIRT1 Pathway in Synergy with Wnt Signaling: Neurotherapeutic Implications to Mitigate Memory Loss in Alzheimer’s Disease
Resveratrol Mediated Regulation of Hippocampal Neuroregenerative Plasticity via SIRT1 Pathway in Synergy with Wnt Signaling: Neurotherapeutic Implications to Mitigate Memory Loss in Alzheimer’s Disease Open
Alzheimer’s disease (AD) is a major form of dementia. Abnormal amyloidogenic event-mediated degeneration of cholinergic neurons in the cognitive centers of the brain has been attributed to neuropathological sequelae and behavioral deficits…
View article: Intertwining Neuropathogenic Impacts of Aberrant Circadian Rhythm and Impaired Neuroregenerative Plasticity in Hutington’s Disease: Neurotherapeutic Significance of Chemogenetics
Intertwining Neuropathogenic Impacts of Aberrant Circadian Rhythm and Impaired Neuroregenerative Plasticity in Hutington’s Disease: Neurotherapeutic Significance of Chemogenetics Open
Huntington’s disease (HD) causes progressive movement disorders and cognitive deficits. Besides, sleep disturbances and emotional distress are prominent clinical signatures of HD. The experimental subjects and HD human brains display…
View article: Liposome encapsulated clodronate mediated elimination of pathogenic macrophages and microglia: A promising pharmacological regime to defuse cytokine storm in COVID-19
Liposome encapsulated clodronate mediated elimination of pathogenic macrophages and microglia: A promising pharmacological regime to defuse cytokine storm in COVID-19 Open
View article: Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder
Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder Open
View article: Single injection of very mild dose botulinum toxin in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice
Single injection of very mild dose botulinum toxin in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice Open
View article: SARS-CoV-2-Mediated Neuropathogenesis, Deterioration of Hippocampal Neurogenesis and Dementia
SARS-CoV-2-Mediated Neuropathogenesis, Deterioration of Hippocampal Neurogenesis and Dementia Open
A significant portion of COVID-19 patients and survivors display marked clinical signs of neurocognitive impairments. SARS-CoV-2-mediated peripheral cytokine storm and its neurotropism appear to elicit the activation of glial cells in the …
View article: Antihemorrhagic Properties of Therapeutic Botulinum Toxin in Experimental Mice
Antihemorrhagic Properties of Therapeutic Botulinum Toxin in Experimental Mice Open