Explanipedia

Short-term outcome following postoperative enhanced recovery implementation in patients with perforated peptic ulcer Open

Amna A. Desoky, Mohammed Akli Ayoub, Neama Mamdouh Mostafa, Eman Hashem, Mona Aly Mohammed · 2025

Objectives To evaluate the short-term outcome following postoperative enhanced recovery implementation in patients with perforated peptic ulcer. Methods Quasi-experimental research design was utilized. Thirty patients received postoperativ…

Functional profiling of synthetic camel milk-derived peptides with implication in glucose transport and diabetes Open

Irfa Anwar, Mir Azam Khan, Bincy Baby, Priya Antony, Priti Mudgil , et al. · 2025

We previously identified protein hydrolysates from camel milk (CM) targeting dipeptidyl peptidase IV (DPP-IV) and insulin receptor (IR) activity. In this study, we synthesized nine peptides (P1 to P9) derived from such CM hydrolysates and …

Temporal complexity of LVV-hemorphin-7 allosterism at the angiotensin II type 1 receptor assessed using entropy-based approaches Open

Herbert Jelinek, Michael P. Johnson, Mir Azam Khan, Mohamed Elgendi, Mohammed Akli Ayoub · 2025

2D nanostructures: Potential in diagnosis and treatment of Alzheimer’s disease Open

Saba Tufail, Mohammad Asif Sherwani, Zahid Shamim, Abdullah, Khang Wen Goh , et al. · 2023

Two-dimensional (2D) nanomaterials have garnered enormous attention seemingly due to their unusual architecture and properties. Graphene and graphene oxide based 2D nanomaterials remained the most sought after for several years but the que…

Invited review: Camel milk–derived bioactive peptides and diabetes—Molecular view and perspectives Open

Mohammed Akli Ayoub, Pei‐Gee Yap, Priti Mudgil, Mir Azam Khan, Irfa Anwar , et al. · 2023

In dairy science, camel milk (CM) constitutes a center of interest for scientists due to its known beneficial effect on diabetes as demonstrated in many in vitro, in vivo, and clinical studies and trials. Overall, CM had positive effects o…

The SARS-CoV-2 Spike Protein Activates the Epidermal Growth Factor Receptor-Mediated Signaling Open

Abdul Rasheed Palakkott, Aysha Alneyadi, Khalid Muhammad, Ali H. Eid, Khaled M. A. Amiri , et al. · 2023

The coronavirus disease-19 (COVID-19) pandemic is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At the molecular and cellular levels, the SARS-CoV-2 uses its envelope glycoprotein, the spike S protein, t…

Multifaceted Pharmacological Potentials of Curcumin, Genistein, and Tanshinone IIA through Proteomic Approaches: An In-Depth Review Open

Mir Azam Khan, Parul Singh, Yahya F. Jamous, Syed Azmal Ali, Abdullah Abdullah , et al. · 2022

Phytochemicals possess various intriguing pharmacological properties against diverse pathological conditions. Extensive studies are on-going to understand the structural/functional properties of phytochemicals as well as the molecular mech…

Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential Open

Mir Azam Khan, Shahab Uddin, Abozer Y. Elderdery, Khang Wen Goh, Long Chiau Ming , et al. · 2022

Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide. Accumulating evidences have highlighted the importance of exosomes and non-coding RNAs (ncRNAs) in cardiac physiology and pathology. It is in general consensu…

A New in Silico Antibody Similarity Measure Both Identifies Large Sets of Epitope Binders with Distinct CDRs and Accurately Predicts Off-Target Reactivity Open

Astrid Musnier, Thomas Bourquard, Amandine Vallet, Laëtitia Mathias, Gilles Bruneau , et al. · 2022

Developing a therapeutic antibody is a long, tedious, and expensive process. Many obstacles need to be overcome, such as biophysical properties (issues of solubility, stability, weak production yields, etc.), as well as cross-reactivity an…

Prospective Role of Bioactive Molecules and Exosomes in the Therapeutic Potential of Camel Milk against Human Diseases: An Updated Perspective Open

Mir Azam Khan, Mohammad Azam Ansari, Shahab Uddin, Abdul Rasheed Palakott, Irfa Anwar , et al. · 2022

Camel milk (CM) constitutes an important dietary source in the hot and arid regions of the world. CM is a colloidal mixture of nutritional components (proteins, carbohydrates, lipids, vitamins, and minerals) and non-nutritional components …

Long-Term Vitamin D Deficiency Results in the Inhibition of Cell Proliferation and Alteration of Multiple Gastric Epithelial Cell Lineages in Mice Open

Shaima Sirajudeen, Iltaf Shah, Mohammed Akli Ayoub, Sherif M. Karam, Asma Al Menhali · 2022

Over one billion people globally are vitamin D (VD) deficient. Studies on the biological roles of VD are numerous but very little on the stomach. This project aims to understand how gastric homeostasis is affected by VD deficiency caused b…

Carnosol Induces p38-Mediated ER Stress Response and Autophagy in Human Breast Cancer Cells Open

Halima Alsamri, Aysha Alneyadi, Khalid Muhammad, Mohammed Akli Ayoub, Ali H. Eid , et al. · 2022

We recently reported that carnosol induces ROS-dependent autophagy and apoptosis in breast cancer cells. We also reported that carnosol inhibits breast cancer cell migration, invasion, and in ovo tumor growth, as well as targets STAT3, PCA…

Novel Pharmacology Following Heteromerization of the Angiotensin II Type 2 Receptor and the Bradykinin Type 2 Receptor Open

Elizabeth K. M. Johnstone, Mohammed Akli Ayoub, Rebecca J. Hertzman, Heng B. See, Rekhati S. Abhayawardana , et al. · 2022

The angiotensin type 2 (AT 2 ) receptor and the bradykinin type 2 (B 2 ) receptor are G protein-coupled receptors (GPCRs) that have major roles in the cardiovascular system. The two receptors are known to functionally interact at various l…

The SARS-CoV-2 Spike Protein Activates the Epidermal Growth Factor Receptor-Mediated Signaling Open

Abdulrasheed Palakkott, Aysha Alneyadi, Khalid Muhammad, Ali H. Eid, Khaled M. A. Amiri , et al. · 2022

Objectives The coronavirus disease-19 (COVID-19) pandemic is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At the molecular and cellular levels, the SARS-Cov-2 uses its envelope glycoprotein, the spike S…

Camel Milk Targeting Insulin Receptor—Toward Understanding the Antidiabetic Effects of Camel Milk Open

Irfa Anwar, Mir Azam Khan, Sajid Maqsood, Mohammed Akli Ayoub · 2022

Camel milk (CM) is known for its beneficial virtues in the human diet and health. This includes its antidiabetic properties demonstrated in many in vitro and in vivo studies. Nevertheless, the scientific rationale behind the molecular and …

Camel and bovine milk lactoferrins activate insulin receptor and its related AKT and ERK1/2 pathways Open

Mir Azam Khan, Irfa Anwar, Elrashdy M. Redwan, Abdulrasheed Palakkott, Arshida Ashraf , et al. · 2021

Lactoferrin (LF) is a milk protein that may be an interesting candidate for the antidiabetic properties of milk due to its well-documented bioactivity and implication in diabetes. Here, we investigated the functional action of LF purified …

Pharmacological Characterization of Low Molecular Weight Biased Agonists at the Follicle Stimulating Hormone Receptor Open

Francesco De Pascali, Mohammed Akli Ayoub, R. Benevelli, Silvia Sposini, Jordan Lehoux , et al. · 2021

Follicle-stimulating hormone receptor (FSHR) plays a key role in reproduction through the activation of multiple signaling pathways. Low molecular weight (LMW) ligands composed of biased agonist properties are highly valuable tools to deci…

Current Insights into Immunology and Novel Therapeutics of Atopic Dermatitis Open

Hidaya Abdul Kader, Muhammad Azeem, Suhib A. Jwayed, Aaesha Al-Shehhi, Attia Tabassum , et al. · 2021

Atopic dermatitis (AD) is one of the most prevalent inflammatory disease among non-fatal skin diseases, affecting up to one fifth of the population in developed countries. AD is characterized by recurrent pruritic and localized eczema with…

Carnosol Is a Novel Inhibitor of p300 Acetyltransferase in Breast Cancer Open

Halima Alsamri, Hussain El Hasasna, Bincy Baby, Aysha Alneyadi, Yusra Al Dhaheri , et al. · 2021

Carnosol, a natural polyphenol abundant in edible plants such as sage, rosemary, and oregano, has shown promising anticancer activity against various types of cancers. Nonetheless, very little is known about its molecular mechanism of acti…

Hemorphins Targeting G Protein-Coupled Receptors Open

Mohammed Akli Ayoub, Ranjit Vijayan · 2021

Hemorphins are short peptides produced by the proteolysis of the beta subunit of hemoglobin. These peptides have diverse physiological effects especially in the nervous and the renin-angiotensin systems. Such effects occur through the modu…

Insights into the Interaction of LVV-Hemorphin-7 with Angiotensin II Type 1 Receptor Open

Amanat Ali, Elizabeth K. M. Johnstone, Bincy Baby, Heng B. See, Angela Song , et al. · 2020

Hemorphins are known for their role in the control of blood pressure. Recently, we revealed the positive modulation of the angiotensin II (AngII) type 1 receptor (AT1R) by LVV-hemorphin-7 (LVV-H7) in human embryonic kidney (HEK293) cells. …

Interplay Between Angiotensin II Type 1 Receptor and Thrombin Receptor Revealed by Bioluminescence Resonance Energy Transfer Assay Open

Isra Al Zamel, Abdulrasheed Palakkott, Arshida Ashraf, Rabah Iratni, Mohammed Akli Ayoub · 2020

The key hormone of the renin-angiotensin system (RAS), angiotensin II (AngII), and thrombin are known to play major roles in the vascular system and its related disorders. Previous studies reported connections between AngII and thrombin in…

Genetic Diversity Analysis of Five Egyptian Buffalo Populations Using Microsatellite Markers Open

S. M. Merdan, M. F. El‐Zarei, Abdullah Ghazy, Mohammed Akli Ayoub, Z. M. Al-Shawa , et al. · 2020

For assessing the genetic diversity and genetic characterization of five Egyptian buffalo populations a total of 12 microsatellite markers were used. The total number of buffaloes sampled was 80, collected at random from five farms in five…

Molecular Basis of the Anti-Diabetic Properties of Camel Milk Through Profiling of Its Bioactive Peptides on DPP-IV and Insulin Receptor Activity Open

Arshida Ashraf, Priti Mudgil, Abdulrasheed Palakkott, Rabah Iratni, Chee‐Yuen Gan , et al. · 2020

Positive Modulation of Angiotensin II Type 1 Receptor–Mediated Signaling by LVV–Hemorphin-7 Open

Amanat Ali, Abdulrasheed Palakkott, Arshida Ashraf, Isra Al Zamel, Bincy Baby , et al. · 2019

Hemorphins are hemoglobin β-chain-derived peptides initially known for their analgesic effects via binding to the opioid receptors belonging to the family of G protein-coupled receptor (GPCR), as well as their physiological action o…

BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes Open

Shannon O’Brien, Elizabeth K. M. Johnstone, Dominic Devost, Jacinta N. Conroy, Melissa E. Reichelt , et al. · 2018

MAbTope: A Method for Improved Epitope Mapping Open

Thomas Bourquard, Astrid Musnier, Vincent Puard, Shifa Tahir, Mohammed Akli Ayoub , et al. · 2018

Abs are very efficient drugs, ∼70 of them are already approved for medical use, over 500 are in clinical development, and many more are in preclinical development. One important step in the characterization and protection of a therapeutic …

Workflow description to dynamically model \beta-arrestin signaling networks Open

Romain Yvinec, Mohammed Akli Ayoub, Francesco De Pascali, Pascale Crépieux, Éric Reiter , et al. · 2018

Dynamic models of signaling networks allow the formulation of hypotheses on the topology and kinetic rate laws characterizing a given molecular network, in-depth exploration and confrontation with kinetic biological data. Despite its stand…

Workflow description to dynamically model β-arrestin signaling networks Open

Romain Yvinec, Mohammed Akli Ayoub, Francesco De Pascali, Pascale Crépieux, Éric Reiter , et al. · 2018

Dynamic models of signaling networks allow the formulation of hypotheses on the topology and kinetic rate laws characterizing a given molecular network, in-depth exploration and confrontation with kinetic biological data. Despite its stand…

Integration of GPCR Signaling and Sorting from Very Early Endosomes via Opposing APPL1 Mechanisms Open

Silvia Sposini, Frédéric Jean‐Alphonse, Mohammed Akli Ayoub, Affiong I Oqua, C. West , et al. · 2017

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