Mahmoud Elfiky
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View article: A proposed basic paediatric surgical skills training course: a pilot, feasibility and outcome study towards standardisation of induction to paediatric surgery training
A proposed basic paediatric surgical skills training course: a pilot, feasibility and outcome study towards standardisation of induction to paediatric surgery training Open
Background Paediatric surgery requires specialised skills, acquired through different traditional and newly applied training methods. However, there are several challenges in paediatric surgery training worldwide, especially among low- and…
View article: Role of Allium cepa and Allium sativum extracts in oxidative stress, sperm parameters and histological abnormalities induced by deep-frying oil in testis
Role of Allium cepa and Allium sativum extracts in oxidative stress, sperm parameters and histological abnormalities induced by deep-frying oil in testis Open
Palm oil is commonly used for deep-frying street food preparation. Extremely vulnerable to oxidative stress and free radicals is testicular tissue. Antioxidant supplements are advised for reducing oxidative stress, boosting spermatogenesis…
View article: Small bowel obstruction outcomes according to compliance with the World Society of Emergency Surgery Bologna guidelines
Small bowel obstruction outcomes according to compliance with the World Society of Emergency Surgery Bologna guidelines Open
Background Small bowel obstruction (SBO) is a common surgical emergency associated with substantial morbidity, hospital length of stay (LOS), and healthcare cost. The World Society of Emergency Surgery (WSES) Bologna guidelines provide evi…
View article: The African Critical Illness Outcomes Study (ACIOS): a point prevalence study of critical illness in 22 nations in Africa
The African Critical Illness Outcomes Study (ACIOS): a point prevalence study of critical illness in 22 nations in Africa Open
National Institute for Health and Care Research (NIHR) Global Health Group in Perioperative and Critical Care (NIHR133850).
View article: The Digital Health Competencies in Medical Education Framework
The Digital Health Competencies in Medical Education Framework Open
Importance Rapid digitalization of health care and a dearth of digital health education for medical students and junior physicians worldwide means there is an imperative for more training in this dynamic and evolving field. Objective To de…
View article: Severe Pain is Associated with Critical Illness and Mortality in Hospitalised Patients Across Africa: A Point Prevalence Study of 22 African Nations
Severe Pain is Associated with Critical Illness and Mortality in Hospitalised Patients Across Africa: A Point Prevalence Study of 22 African Nations Open
View article: Machine learning in action: Revolutionizing intracranial hematoma detection and patient transport decision-making
Machine learning in action: Revolutionizing intracranial hematoma detection and patient transport decision-making Open
Objectives: Traumatic intracranial hematomas represent a critical clinical situation where early detection and management are of utmost importance. Machine learning has been recently used in the detection of neuroradiological findings. Hen…
View article: Outcome of primary posterior tracheopexy in thoracoscopically repaired esophageal atresia neonates with tracheomalacia; single center's experience
Outcome of primary posterior tracheopexy in thoracoscopically repaired esophageal atresia neonates with tracheomalacia; single center's experience Open
Background: Tracheomalacia frequently develops in esophageal atresia patients (EA) especially in those with tracheoesophageal fistula (TEF). Conservative management has been the standard treatment; however, it was reported that delay in ma…
View article: Comparative study of laparoscopic Nissen fundoplication versus Hill-Snow procedure for the treatment of gastroesophageal reflux disease in children: a single-blinded randomized controlled trial
Comparative study of laparoscopic Nissen fundoplication versus Hill-Snow procedure for the treatment of gastroesophageal reflux disease in children: a single-blinded randomized controlled trial Open
Background Gastroesophageal reflux disease (GERD) is a common condition in children. Complete fundoplication provides better reflux control but it results in more dysphagia and gas-bloat symptoms. Antireflux surgery without wrap has fewer …
View article: Outcomes after Surgery for Children in Africa a Fourteen-Day Prospective Observational Cohort Study (ASOS-Paeds)
Outcomes after Surgery for Children in Africa a Fourteen-Day Prospective Observational Cohort Study (ASOS-Paeds) Open
View article: Comparative study between one-stage versus three-stage repair of anorectal malformation with recto-vestibular fistula
Comparative study between one-stage versus three-stage repair of anorectal malformation with recto-vestibular fistula Open
Background This is a retrospective comparative study that aimed to compare the short-term and intermediate-term outcomes of the one-stage and three-stage repair in the treatment of female neonates with a recto-vestibular fistula. Female pa…
View article: Determining the Minimum Dataset for Surgical Patients in Africa: A Delphi Study
Determining the Minimum Dataset for Surgical Patients in Africa: A Delphi Study Open
Background It is often difficult for clinicians in African low‐ and middle‐income countries middle‐income countries to access useful aggregated data to identify areas for quality improvement. The aim of this Delphi study was to develop a s…
View article: Nurses’ Priorities for Perioperative Research in Africa
Nurses’ Priorities for Perioperative Research in Africa Open
BACKGROUND: Mortality rates among surgical patients in Africa are double those of surgical patients in high-income countries. Internationally, there is a call to improve access to and safety of surgical and perioperative care. Perioperativ…
View article: Impact of the COVID-19 pandemic on patients with paediatric cancer in low-income, middle-income and high-income countries: a multicentre, international, observational cohort study
Impact of the COVID-19 pandemic on patients with paediatric cancer in low-income, middle-income and high-income countries: a multicentre, international, observational cohort study Open
Objectives Paediatric cancer is a leading cause of death for children. Children in low-income and middle-income countries (LMICs) were four times more likely to die than children in high-income countries (HICs). This study aimed to test th…
View article: Rare and de novo variants in 827 congenital diaphragmatic hernia probands implicate LONP1 as candidate risk gene
Rare and de novo variants in 827 congenital diaphragmatic hernia probands implicate LONP1 as candidate risk gene Open
View article: Enhanced postoperative surveillance versus standard of care to reduce mortality among adult surgical patients in Africa (ASOS-2): a cluster-randomised controlled trial
Enhanced postoperative surveillance versus standard of care to reduce mortality among adult surgical patients in Africa (ASOS-2): a cluster-randomised controlled trial Open
View article: Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study Open
View article: Rare and <i>de novo</i> variants in 827 congenital diaphragmatic hernia probands implicate <i>LONP1</i> and <i>ALYREF</i> as new candidate risk genes
Rare and <i>de novo</i> variants in 827 congenital diaphragmatic hernia probands implicate <i>LONP1</i> and <i>ALYREF</i> as new candidate risk genes Open
Congenital diaphragmatic hernia (CDH) is a severe congenital anomaly that is often accompanied by other anomalies. Although the role of genetics in the pathogenesis of CDH has been established, only a small number of disease genes have bee…
View article: Patient care and clinical outcomes for patients with COVID-19 infection admitted to African high-care or intensive care units (ACCCOS): a multicentre, prospective, observational cohort study
Patient care and clinical outcomes for patients with COVID-19 infection admitted to African high-care or intensive care units (ACCCOS): a multicentre, prospective, observational cohort study Open
View article: Novel candidate genes in esophageal atresia/tracheoesophageal fistula identified by exome sequencing
Novel candidate genes in esophageal atresia/tracheoesophageal fistula identified by exome sequencing Open
View article: An African, Multi-Centre Evaluation of Patient Care and Clinical Outcomes for Patients with COVID-19 Infection Admitted to High-Care or Intensive Care Units
An African, Multi-Centre Evaluation of Patient Care and Clinical Outcomes for Patients with COVID-19 Infection Admitted to High-Care or Intensive Care Units Open
View article: De novo variants in congenital diaphragmatic hernia identify MYRF as a new syndrome and reveal genetic overlaps with other developmental disorders
De novo variants in congenital diaphragmatic hernia identify MYRF as a new syndrome and reveal genetic overlaps with other developmental disorders Open
Congenital diaphragmatic hernia (CDH) is a severe birth defect that is often accompanied by other congenital anomalies. Previous exome sequencing studies for CDH have supported a role of de novo damaging variants but did not identify any r…
View article: Implementation of a bowel management program in the treatment of incontinence in children for primary healthcare providers
Implementation of a bowel management program in the treatment of incontinence in children for primary healthcare providers Open
Objectives: Our surgical team has devised a bowel management program (BMP) as a basic approach for primary healthcare providers with the least use of resources.Background: Soiling in children is a major problem that has a serious impact on…
View article: Perioperative patient outcomes in the African Surgical Outcomes Study: a 7-day prospective observational cohort study
Perioperative patient outcomes in the African Surgical Outcomes Study: a 7-day prospective observational cohort study Open
View article: Genetic analysis of<i>de novo</i>variants reveals sex differences in complex and isolated congenital diaphragmatic hernia and indicates<i>MYRF</i>as a candidate gene
Genetic analysis of<i>de novo</i>variants reveals sex differences in complex and isolated congenital diaphragmatic hernia and indicates<i>MYRF</i>as a candidate gene Open
Congenital diaphragmatic hernia (CDH) is one of the most common and lethal birth defects. Previous studies using exome sequencing support a significant contribution of coding de novo variants in complex CDH cases with additional anomalies …