Mahmoud Abdellatif
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View article: Deletion of MMP12 improves energy metabolism and brown adipose tissue function in mice prone to cardiometabolic disease
Deletion of MMP12 improves energy metabolism and brown adipose tissue function in mice prone to cardiometabolic disease Open
Matrix metalloproteinase-12 (MMP12) is a proinflammatory macrophage-secreted protein with immunomodulatory functions that affects neutrophil infiltration, cytokine release, macrophage recruitment, and proliferation. We have previously demo…
View article: Adipose Triglyceride Lipase Knockout Increases Anticontractile Effects of Perivascular Adipose Tissue
Adipose Triglyceride Lipase Knockout Increases Anticontractile Effects of Perivascular Adipose Tissue Open
BACKGROUND: Perivascular adipose tissue (PVAT) fine-tunes blood vessel contractility and vascular homeostasis. During obesity and atherosclerosis, PVAT becomes dysfunctional and loses its anticontractile potential. Previously, we reported …
View article: Unlocking metabolic flexibility in heart failure with preserved ejection fraction: Bridging fundamental mechanisms to clinical innovation
Unlocking metabolic flexibility in heart failure with preserved ejection fraction: Bridging fundamental mechanisms to clinical innovation Open
Heart failure is often described as a condition of "energy depletion." However, in heart failure with preserved ejection fraction (HFpEF), particularly when associated with metabolic conditions such as obesity and diabetes, the heart may f…
View article: Specific targeting of adipose tissue metabolism is superior to caloric restriction in treating obesity-related HFpEF
Specific targeting of adipose tissue metabolism is superior to caloric restriction in treating obesity-related HFpEF Open
View article: Acyl-CoA-binding protein as a driver of pathological aging
Acyl-CoA-binding protein as a driver of pathological aging Open
The tissue hormone acyl coenzyme A–binding protein (ACBP, encoded by the gene diazepam-binding inhibitor , DBI) has been implicated in various facets of pathological aging. Here, we show that ACBP plasma concentrations are elevated in (clo…
View article: Mechano-energetic uncoupling in heart failure
Mechano-energetic uncoupling in heart failure Open
View article: Potent immune-dependent anticancer effects of the non-cardiotoxic anthracycline aclarubicin
Potent immune-dependent anticancer effects of the non-cardiotoxic anthracycline aclarubicin Open
Aclarubicin (also called aclacinomycin A) is an antineoplastic from the anthracycline class that is used in China and Japan but not in Europe nor in the USA. Aclarubicin induces much less DNA damage than the classical anthracyclines doxoru…
View article: SAFETY AND EFFICACY OF ADALIMUMAB THERAPY FOR TREATMENT OF BEHCET’S DISEASE-RELATED UVEITIS IN SOHAG UNIVERSITY HOSPITAL
SAFETY AND EFFICACY OF ADALIMUMAB THERAPY FOR TREATMENT OF BEHCET’S DISEASE-RELATED UVEITIS IN SOHAG UNIVERSITY HOSPITAL Open
View article: Inhibition of Adipose Tissue Lipolysis Treats Obesity-Related HFpEF
Inhibition of Adipose Tissue Lipolysis Treats Obesity-Related HFpEF Open
View article: Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the <scp>ESC</scp> Working Group on Cellular Biology of the Heart and the <scp>ESC</scp> Working Group on Myocardial Function
Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the <span>ESC</span> Working Group on Cellular Biology of the Heart and the <span>ESC</span> Working Group on Myocardial Function Open
Acute myocardial infarction (MI) remains a major cause of death and disability worldwide. No adjuvant treatment has yet been fully validated in patients to limit the progression from the initial tissue damage due to acute MI, to the develo…
View article: Obesity accelerates cardiovascular ageing
Obesity accelerates cardiovascular ageing Open
A global obesity pandemic, coupled with an increasingly ageing population, is exacerbating the burden of cardiovascular disease. Indeed, clinical and experimental evidence underscores a potential connection between obesity and ageing in th…
View article: Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction
Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction Open
View article: Roadmap for alleviating the manifestations of ageing in the cardiovascular system
Roadmap for alleviating the manifestations of ageing in the cardiovascular system Open
View article: The ESC Working Group on Myocardial Function
The ESC Working Group on Myocardial Function Open
View article: Phosphorylation of CRYAB induces a condensatopathy to worsen post–myocardial infarction left ventricular remodeling
Phosphorylation of CRYAB induces a condensatopathy to worsen post–myocardial infarction left ventricular remodeling Open
Protein aggregates are emerging therapeutic targets in rare monogenic causes of cardiomyopathy and amyloid heart disease, but their role in more prevalent heart-failure syndromes remains mechanistically unexamined. We observed mislocalizat…
View article: Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential
Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential Open
View article: Clinical evidence for the use of NAD+ precursors to slow aging
Clinical evidence for the use of NAD+ precursors to slow aging Open
Significant progress in clinical care has extended human life expectancy to unprecedented levels. However, this trend has been parallelled by a rise in years lived with poor health, posing profound challenges not only to individual quality…
View article: AI-based classification of anticancer drugs reveals nucleolar condensation as a predictor of immunogenicity
AI-based classification of anticancer drugs reveals nucleolar condensation as a predictor of immunogenicity Open
We developed AI-based algorithms for predicting CON-inducing drugs based on molecular descriptors and their validation using automated micrographs analysis, offering a new approach for screening ICD inducers with minimized adverse effects …
View article: Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction
Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction Open
Aims ZSF1 obese rats harbouring two mutant leptin receptor alleles ( Lepr cp and Lepr fa ) develop metabolic syndrome and heart failure with preserved ejection fraction (HFpEF), making them a widely used animal model in cardiometabolic res…
View article: Coronary Computed Tomography Angiography in Patients with Non-ST-Segment Elevation Acute Coronary Syndrome
Coronary Computed Tomography Angiography in Patients with Non-ST-Segment Elevation Acute Coronary Syndrome Open
View article: Phosphorylation of CRYAB Induces a Condensatopathy to Worsen Post-Myocardial Infarction Left Ventricular Remodeling
Phosphorylation of CRYAB Induces a Condensatopathy to Worsen Post-Myocardial Infarction Left Ventricular Remodeling Open
Protein aggregates are emerging therapeutic targets in rare monogenic causes of cardiomyopathy and amyloid heart disease, but their role in more prevalent heart failure syndromes remains mechanistically unexamined. We observed mis-localiza…
View article: A surge in endogenous spermidine is essential for rapamycin-induced autophagy and longevity
A surge in endogenous spermidine is essential for rapamycin-induced autophagy and longevity Open
Acute nutrient deprivation (fasting) causes an immediate increase in spermidine biosynthesis in yeast, flies, mice and humans, as corroborated in four independent clinical studies. This fasting-induced surge in spermidine constitutes the c…
View article: Targeting organ-specific mitochondrial dysfunction to improve biological aging
Targeting organ-specific mitochondrial dysfunction to improve biological aging Open
In an aging society, unveiling new anti-aging strategies to prevent and combat aging-related diseases is of utmost importance. Mitochondria are the primary ATP production sites and key regulators of programmed cell death. Consequently, the…
View article: Anti-ageing interventions for the treatment of cardiovascular disease
Anti-ageing interventions for the treatment of cardiovascular disease Open
As the global demographic landscape continues to shift towards an aged population, so does the medical and socioeconomic burden of cardiovascular diseases. Indeed, ageing is one of, if not, the key risk factor for the development of cardio…
View article: Spermidine is essential for fasting-mediated autophagy and longevity
Spermidine is essential for fasting-mediated autophagy and longevity Open
View article: Mechanisms of myocardial reverse remodelling and its clinical significance: A scientific statement of the ESC Working Group on Myocardial Function
Mechanisms of myocardial reverse remodelling and its clinical significance: A scientific statement of the ESC Working Group on Myocardial Function Open
Cardiovascular disease (CVD) is the leading cause of morbimortality in Europe and worldwide. CVD imposes a heterogeneous spectrum of cardiac remodelling, depending on the insult nature, that is, pressure or volume overload, ischaemia, arrh…
View article: Ketone body levels and its associations with cardiac markers following an acute myocardial infarction: a post hoc analysis of the EMMY trial
Ketone body levels and its associations with cardiac markers following an acute myocardial infarction: a post hoc analysis of the EMMY trial Open
Background Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have been suggested to exert cardioprotective effects in patients with heart failure, possibly by improving the metabolism of ketone bodies in the myocardium. Methods This post…
View article: Risks and Benefits of Intermittent Fasting for the Aging Cardiovascular System
Risks and Benefits of Intermittent Fasting for the Aging Cardiovascular System Open
Population aging and the associated increase in cardiovascular disease rates pose serious threats to global public health. Different forms of fasting have become an increasingly attractive strategy to directly address aging and potentially…
View article: Actionable autophagy checkpoints in cardiovascular ageing
Actionable autophagy checkpoints in cardiovascular ageing Open
View article: Acyl coenzyme A binding protein (<scp>ACBP</scp>): An aging‐ and disease‐relevant “autophagy checkpoint”
Acyl coenzyme A binding protein (<span>ACBP</span>): An aging‐ and disease‐relevant “autophagy checkpoint” Open
Acyl coenzyme A binding protein (ACBP), also known as diazepam‐binding inhibitor (DBI), is a phylogenetically ancient protein present in some eubacteria and the entire eukaryotic radiation. In several eukaryotic phyla, ACBP/DBI transcends …