Mahmut Özsahin
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View article: Reirradiation − still navigating uncharted waters?
Reirradiation − still navigating uncharted waters? Open
With the emergence of high-precision radiotherapy technologies such as stereotactic ablative radiotherapy (SABR), MR guided brachytherapy, image guided intensity modulated photon and proton radiotherapy and most recently daily adaptive rad…
View article: Radiation-induced lymphocyte apoptosis assay: Primetime for routine clinical use?
Radiation-induced lymphocyte apoptosis assay: Primetime for routine clinical use? Open
The impact of curative radiotherapy mainly depends on the total dose delivered to the tumor. However, despite recent technological advances, the dose delivered to surrounding healthy tissues may reduce the therapeutic ratio of many radiati…
View article: Figure S1b from The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients
Figure S1b from The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients Open
Figure S1B- Higher magnification showing the skin of the mini-pig 15 and 32 weeks post radiotherapy (RT). At 15 weeks, skin area irradiated with 31Gy-FLASH-RT shows hair regrowth but not with 31Gy-Conv-RT. At 32 weeks, skin area irradiated…
View article: Figure S1a from The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients
Figure S1a from The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients Open
Figure S1: A- Serial pictures showing evolution of the mini-pig's skin over time post FLASH and Conv-RT. Three doses are shown (28-34Gy) 24h to 32 weeks post-RT.
View article: Figure S1a from The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients
Figure S1a from The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients Open
Figure S1: A- Serial pictures showing evolution of the mini-pig's skin over time post FLASH and Conv-RT. Three doses are shown (28-34Gy) 24h to 32 weeks post-RT.
View article: Supplementary Data from The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients
Supplementary Data from The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients Open
Supplementary Data Table S1: WHO staging system (TNM Classification of Tumors in Domestic Animals. Geneva: World Health Organization; 1980) Table S2: Cat patient and treatment characteristics
View article: Figure S1b from The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients
Figure S1b from The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients Open
Figure S1B- Higher magnification showing the skin of the mini-pig 15 and 32 weeks post radiotherapy (RT). At 15 weeks, skin area irradiated with 31Gy-FLASH-RT shows hair regrowth but not with 31Gy-Conv-RT. At 32 weeks, skin area irradiated…
View article: Data from The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients
Data from The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients Open
Purpose:Previous studies using FLASH radiotherapy (RT) in mice showed a marked increase of the differential effect between normal tissue and tumors. To stimulate clinical transfer, we evaluated whether this effect could also occur in highe…
View article: Data from The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients
Data from The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients Open
Purpose:Previous studies using FLASH radiotherapy (RT) in mice showed a marked increase of the differential effect between normal tissue and tumors. To stimulate clinical transfer, we evaluated whether this effect could also occur in highe…
View article: Supplementary Data from The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients
Supplementary Data from The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients Open
Supplementary Data Table S1: WHO staging system (TNM Classification of Tumors in Domestic Animals. Geneva: World Health Organization; 1980) Table S2: Cat patient and treatment characteristics
View article: Re-irradiation of recurrent vertebral metastasis after two previous spinal cord irradiation: A case report
Re-irradiation of recurrent vertebral metastasis after two previous spinal cord irradiation: A case report Open
Background Management of a recurrent vertebral metastasis in a situation of previously irradiated spinal cord is a challenging clinical dilemma. Case presentation We report a first case of second retreatment of a spinal metastasis initiall…
View article: Recurrences after stereotactic arrhythmia radioablation for refractory ventricular tachycardia
Recurrences after stereotactic arrhythmia radioablation for refractory ventricular tachycardia Open
Introduction Stereotactic arrhythmia radioablation (STAR) has been recently introduced for the management of ventricular tachycardia (VT) refractory to antiarrhythmic drugs (AADs) and catheter ablation (CA). VT recurrences were recently re…
View article: Improving Patients’ Life Quality after Radiotherapy Treatment by Predicting Late Toxicities
Improving Patients’ Life Quality after Radiotherapy Treatment by Predicting Late Toxicities Open
Personalized treatment and precision medicine have become the new standard of care in oncology and radiotherapy. Because treatment outcomes have considerably improved over the last few years, permanent side-effects are becoming an increasi…
View article: Comparison of ultra-high versus conventional dose rate radiotherapy in a patient with cutaneous lymphoma
Comparison of ultra-high versus conventional dose rate radiotherapy in a patient with cutaneous lymphoma Open
A patient with a cutaneous lymphoma was treated on the same day for 2 distinct tumors using a 15 Gy single electron dose given in a dose rate of 0.08 Gy/second versus 166 Gy/second. Comparing the two treatments, there was no difference for…
View article: Stage III N2 non-small cell lung cancer treatment: decision-making among surgeons and radiation oncologists
Stage III N2 non-small cell lung cancer treatment: decision-making among surgeons and radiation oncologists Open
Both, surgery- or radiotherapy-based treatment regimens are feasible options in the management of Stage III N2 NSCLC. The different opinions reflected in the results of this manuscript reinforce the importance of a multidisciplinary settin…
View article: Outils pour la prédiction de la réponse tumorale et des tissus sains en oncologie radiothérapie
Outils pour la prédiction de la réponse tumorale et des tissus sains en oncologie radiothérapie Open
View article: Quantitative proteomic analysis reveals AK2 as potential biomarker for late normal tissue radiotoxicity
Quantitative proteomic analysis reveals AK2 as potential biomarker for late normal tissue radiotoxicity Open
View article: Personnalisation de la dose, du volume et du fractionnement de la radiothérapie du sein
Personnalisation de la dose, du volume et du fractionnement de la radiothérapie du sein Open
View article: Contents
Contents Open
View article: Isodose 20 Gy found as a threshold dose for radiation recall dermatitis
Isodose 20 Gy found as a threshold dose for radiation recall dermatitis Open
Radiation recall is a rare phenomenon that can be observed in the field of radiotherapy, months or years after irradiation when a patient is exposed to certain pharmaceutical agents. In this report, we relate a case of radiation recall der…
View article: Emerging patient-specific treatment modalities in head and neck cancer – a systematic review
Emerging patient-specific treatment modalities in head and neck cancer – a systematic review Open
Currently, patient-specific treatment modalities in HNC mainly consist of active immunotherapy using adoptive cell therapies and/or gene engineered vectors. Despite the slow pace of development, the interest continues in these treatment mo…
View article: Selection of lymph node target volumes for definitive head and neck radiation therapy: a 2019 Update
Selection of lymph node target volumes for definitive head and neck radiation therapy: a 2019 Update Open
View article: Position of a panel of international lung cancer experts on the approval decision for use of durvalumab in stage III non-small-cell lung cancer (NSCLC) by the Committee for Medicinal Products for Human Use (CHMP)
Position of a panel of international lung cancer experts on the approval decision for use of durvalumab in stage III non-small-cell lung cancer (NSCLC) by the Committee for Medicinal Products for Human Use (CHMP) Open
View article: Hepatobiliary scintigraphy allows the evaluation of short-term functional toxicity of liver stereotactic body radiotherapy: Results of a pilot study
Hepatobiliary scintigraphy allows the evaluation of short-term functional toxicity of liver stereotactic body radiotherapy: Results of a pilot study Open
HBS could improve treatment plans for liver SBRT, by allowing the identification of the liver function variations after SBRT and, potentially, the prediction of remnant liver function after SBRT. These preliminary results should be confirm…
View article: Management of locally advanced anal canal carcinoma with intensity-modulated radiotherapy and concurrent chemotherapy
Management of locally advanced anal canal carcinoma with intensity-modulated radiotherapy and concurrent chemotherapy Open
View article: (18F)-FDG PET/CT parameters to predict survival and recurrence in patients with locally advanced cervical cancer treated with chemoradiotherapy
(18F)-FDG PET/CT parameters to predict survival and recurrence in patients with locally advanced cervical cancer treated with chemoradiotherapy Open
View article: EP-2179: Assessment of lung position reproducibility of High-Frequency Ventilation (HFV) in radiation therapy
EP-2179: Assessment of lung position reproducibility of High-Frequency Ventilation (HFV) in radiation therapy Open
View article: Comparison of 3DCRT and VMAT treatment in neoadjuvant oesophageal cancer
Comparison of 3DCRT and VMAT treatment in neoadjuvant oesophageal cancer Open
View article: Modern intensity-modulated radiotherapy with image guidance allows low toxicity rates and good local control in chemoradiotherapy for anal cancer patients
Modern intensity-modulated radiotherapy with image guidance allows low toxicity rates and good local control in chemoradiotherapy for anal cancer patients Open
View article: Outcome of proximal esophageal cancer after definitive combined chemo-radiation: a Swiss multicenter retrospective study
Outcome of proximal esophageal cancer after definitive combined chemo-radiation: a Swiss multicenter retrospective study Open