Explanipedia

Insights into repurposing telmisartan beyond its cardiovascular applications: Emphasis on the metabolic, neuroprotective, nephroprotective and anticancer potential Open

Hadi Nassar, Maha R. A. Abdollah, Sara A. El Wakeel, Mai F. Tolba · 2025

The landscape of cyclin-dependent kinase 4/6 inhibitors in solid malignancies: emphasis on immunotherapy combinatorial strategies Open

Shakira Hussein, Ahmed H. Saadawy, Eman Badr, Maha R. A. Abdollah, N Wael , et al. · 2025

Given the pivotal role of CDK4/6 deregulation in the pathogenesis of various malignancies, CDK4/6 inhibitors have been incorporated into cancer treatment protocols. Beyond their antiproliferative effects, these inhibitors exhibit prominent…

Trimetazidine mitigates methotrexate‐induced liver damage: Insights From biochemical, histological, and in silico analyses Open

Maha R. A. Abdollah, Mohamed H. Aly, Maha E. Wally, Nada K. Sedky, Ahmed H. Saadawy , et al. · 2025

This study aimed at generating preliminary evidence for the potential utility of repurposing the clinically approved anti‐ischemic drug trimetazidine (TMZ) against methotrexate (MTX)‐induced hepatotoxicity. In this study, rats received MTX…

Editorial: Emerging talents in pharmacology of anti-cancer drugs 2022 Open

Husain Yar Khan, Khuloud Bajbouj, Mai F. Tolba · 2023

EDITORIAL article Front. Pharmacol., 19 April 2023Sec. Pharmacology of Anti-Cancer Drugs Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1191321

Insights into the neuroprotective properties of Biochanin-A Open

Sarah Hussein, Mai F. Tolba, Haidy E. Michel, Samar S. Azab · 2022

The global morbidity and mortality caused by neurological disorders are significant. Neurodegenerative disorders are anticipated to rise as the population ages because they typically manifest in mid-to-late life. The World Health Organizat…

Implications of WHO COVID-19 interim guideline 2020.5 on the comprehensive care for infected persons in Africa Before, during and after clinical management of cases Open

Adeniyi Francis Fagbamigbe, Mai F. Tolba, Ebenezer Forkuo Amankwaa, Priscilla Kolibea Mante, Augustina Angelina Sylverken , et al. · 2021

Editorial: Immunotherapy as an Evolving Approach for the Treatment of Breast Cancer Open

Mai F. Tolba, Cesar A. Santa‐Maria, Adriana Albini, Emile R. Chimusa, Basel K. al-Ramadi , et al. · 2021

EDITORIAL article Front. Oncol., 24 November 2021Sec. Breast Cancer Volume 11 - 2021 | https://doi.org/10.3389/fonc.2021.752689

SARS-CoV-2 Viral Shedding and Transmission Dynamics: Implications of WHO COVID-19 Discharge Guidelines Open

Kingsley Badu, Kolapo Oyebola, Julien Z. B. Zahouli, Adeniyi Francis Fagbamigbe, Dziedzom K. de Souza , et al. · 2021

The evolving nature of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has necessitated periodic revisions of COVID-19 patient treatment and discharge guidelines. Since the identification of the first COVID-19 cases in Nov…

Molecular Modeling Studies on Biochanin-A as a Potential Dual inhibitor for VEGFR-2 and Cyclin D1-CDK-4 Complex Open

Mohamed Ramadan, Dalal Abu-ELElla, Mai F. Tolba, Amgad Albohy, Suher Zada · 2021

Biochanin-A is a known phytoestrogen that is mainly found in red clover. It has several biological activities including anticancer, anti-inflammatory and antioxidant effects. Preclinical studies showed that Biochanin-A has anticancer prope…

Effect of Viscum album extract on angiogenesis mediators and cytokines in Egyptian patients with intermediate hepatocellular carcinoma Open

Marwa Elmelegy, Heba Mohamed Abdella, Wesam M. El‐Bakly, Mai F. Tolba, Ebtehal El‐Demerdash · 2021

Background:Transarterial chemoembolization(TACE)is the most widely used treatment worldwide for intermediate unresectable hepatocellular carcinoma(HCC).New systemic therapies have shown survival benefits but looking ahead to the future of …

Investigation of the clinical outcomes of long-term vitamin D supplementation in Egyptian Type 2 Diabetes Mellitus patients Open

Yahya ElNaggar, Ebtehal El‐Demerdash, Mai F. Tolba, Mohamed Reda Halawa · 2021

Background: Diabetes mellitus (DM) is a group of metabolic disorders Characterized by chronic hyperglycaemic condition resulting from defects in insulin secretion, insulin action or both. Type2 Diabetes Mellitus (T2DM) is the predominant f…

Correlating WHO COVID-19 interim guideline 2020.5 and testing capacity, accuracy, and logistical challenges in Africa Open

Lydia Mosi, Augustina Angelina Sylverken, Kolapo Oyebola, Kingsley Badu, Natisha Dukhi , et al. · 2021

Coronavirus disease 2019 (COVID-19), a severe acute respiratory syndrome caused by SARS-CoV-2 was declared a global pandemic by the World Health Organization (WHO) in March 2020. As of 21^st April 2021, the disease had affected m…

Wogonin Hampers Dexamethasone-Induced Oxidative Imbalance in Sprague Dawely Rats Open

Maha Hassanin, Mai F. Tolba, Marianne Tadros, Mohamed M. Elmazar, Abdel Nasser B. Singab · 2020

Corticosteroids are frequently used for their powerful anti-inflammatory activity in the management of various chronic inflammatory diseases. They are also used because of their potent immunosuppressive power in the manipulation of adverse…

Revolutionizing the landscape of colorectal cancer treatment: The potential role of immune checkpoint inhibitors Open

Mai F. Tolba · 2020

Colorectal cancer (CRC) represents the third cause of cancer‐related mortalities worldwide. The progression of CRC to the metastatic phase significantly compromises the overall survival rates. Despite the advances in the therapeutic protoc…

Immunomodulatory MicroRNAs in cancer: targeting immune checkpoints and the tumor microenvironment Open

Hany A. Omar, Ahmed El-Serafi, Fatema Hersi, El‐Shaimaa A. Arafa, Dana M. Zaher , et al. · 2019

Cancer immunotherapy represents a promising new era in cancer management due to the relatively high safety margins and selectivity, compared to the classical cancer chemotherapeutic agents. However, there is an imperative need to overcome …

Wogonin a Promising Component of Scutellaria baicalensis: A Review on its Chemistry, Pharmacokinetics and Biological Activities Open

Maha Hassanin, Mai F. Tolba, Marianne Tadros, Mohamed M. Elmazar, Abdel Nasser B. Singab · 2019

Scutellaria baicalensis Georgi (Huang-Qin or Chinese skullcap) is a native medicinal plant in China that is commonly used for the treatment of seizures, viral infections, and cancer.The numerous pharmacodynamics of this plant is referred t…

Caffeic acid phenethyl ester guards against benign prostate hypertrophy in rats: Role of IGF‐1R/protein kinase‐B (Akt)/β‐catenin signaling Open

Hany A. Omar, Mai F. Tolba · 2018

Benign prostate hypertrophy (BPH) is among the most common diseases with a huge impact on the quality of life of elderly men. There is a current need for the development of well‐tolerated and effective preventive strategies to improve the …

OSU-2S/Sorafenib Synergistic Antitumor Combination against Hepatocellular Carcinoma: The Role of PKCδ/p53 Open

Hany A. Omar, Mai F. Tolba, Jui‐Hsiang Hung, Taleb H. Al‐Tel · 2016

Background: Sorafenib (Nexavar^®) is an FDA-approved systemic therapy for advanced hepatocellular carcinoma (HCC). However, the low efficacy and adverse effects at high doses limit the clinical application of sorafenib and…

Novel combination of sorafenib and biochanin-A synergistically enhances the anti-proliferative and pro-apoptotic effects on hepatocellular carcinoma cells Open

Mohieldin Youssef, Mai F. Tolba, Noha N. Badawy, Andrew W. Liu, Eman El‐Ahwany , et al. · 2016

The chemomodulatory effects of glufosfamide on docetaxel cytotoxicity in prostate cancer cells Open

Reem T. Attia, Mai F. Tolba, Ruchit Trivedi, Mariane G. Tadros, Hossam M.M. Arafa , et al. · 2016

Background . Glufosfamide (GLU) is a glucose conjugate of ifosfamide in which isophosphoramide mustard is glycosidically linked to the β -D-glucose molecule. Based on GLU structure, it is considered a targeted chemotherapy with fewer side …

Pterostilbine, an active component of blueberries, sensitizes colon cancer cells to 5-fluorouracil cytotoxicity Open

Mai F. Tolba, Sherif Z. Abdel‐Rahman · 2015

Although colorectal cancer (CRC) treatment with 5-fluorouracil (5-FU) is the first line of therapy for this debilitating disease, treatment effectiveness is often hampered by the development of drug resistance and toxicity at high doses. E…

Discovery of Potent Antiproliferative Agents Targeting EGFR Tyrosine Kinase Based on the Pyrido[3′,2′:4,5]thieno[3,2-<i>d</i>]pyrimidin-4-amine Scaffold Open

Yasmine M. Abdel Aziz, Mohamed M. Said, Hosam A. El Shihawy, Mai F. Tolba, Khaled A. M. Abouzid · 2015

A series of pyridothieno[3,2-d]pyrimidin-4-amines was designed and synthesized as congeners to the classical 4-anilinoquinazolines as ATP-competitive epidermal growth factor receptor (EGFR) inhibitors. Compound 5a exhibited the most potent…

Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts Open

C E Cross, Mai F. Tolba, Catherine M. Rondelli, Meixiang Xu, Sherif Z. Abdel‐Rahman · 2015

The relationship between oxidative stress and miRNA changes in placenta as a potential mechanism involved in preeclampsia (PE) is not fully elucidated. We investigated the impact of oxidative stress on miRNAs and mRNA expression profiles o…

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