Mai Iwaya
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View article: A case of hepatic segmental atrophy mimicking spontaneously necrotized hepatocellular carcinoma
A case of hepatic segmental atrophy mimicking spontaneously necrotized hepatocellular carcinoma Open
We report a rare case of hepatic segmental atrophy that was initially suspected to be hepatocellular carcinoma (HCC). An 80-year-old man presented with a new 3 cm hepatic lesion that met LI-RADS-5 criteria. However, follow-up CT performed …
View article: High KCNJ14 expression is associated with an immunosuppressive tumor microenvironment and advanced pathological features: An RNA in situ hybridization-based analysis of colorectal carcinoma
High KCNJ14 expression is associated with an immunosuppressive tumor microenvironment and advanced pathological features: An RNA in situ hybridization-based analysis of colorectal carcinoma Open
Colorectal carcinoma (CRC) remains one of the leading causes of cancer-related deaths worldwide, and there is a lack of reliable biomarkers to predict tumor progression and the immune microenvironment. KCNJ14 is a member of the inwardly re…
View article: Prognostic Significance of Bile Duct Loss in Early‐Stage Primary Biliary Cholangitis: A Long‐Term Observational Study
Prognostic Significance of Bile Duct Loss in Early‐Stage Primary Biliary Cholangitis: A Long‐Term Observational Study Open
Background & Aims Primary biliary cholangitis (PBC) is a chronic, slowly progressive, and autoimmune liver disease. This study aimed to establish the clinicopathological features that accurately predict long‐term prognosis in patients with…
View article: Shedding Phosphorylated Axl Receptor in Lung Adenocarcinoma: Dual-Domain Immunohistochemistry Approach
Shedding Phosphorylated Axl Receptor in Lung Adenocarcinoma: Dual-Domain Immunohistochemistry Approach Open
Shedding pAxl has a prognostic impact on lung adenocarcinoma, with a significant effect modification related to STAS. The developed shedding pAxl score, strongly associated with EMT, provides foundational knowledge for further studies on t…
View article: A Resected Case of β-Catenin-Activated Hepatocellular Adenoma with Tumor Rupture
A Resected Case of β-Catenin-Activated Hepatocellular Adenoma with Tumor Rupture Open
View article: Synthetic short mRNA prevents metastasis via innate-adaptive immunity
Synthetic short mRNA prevents metastasis via innate-adaptive immunity Open
View article: Vascular E-selectin Expression Recognized by the U12-12 Monoclonal Antibody as a Predictive Marker for Steroid Resistance in Immune Checkpoint Inhibitor-related Colitis
Vascular E-selectin Expression Recognized by the U12-12 Monoclonal Antibody as a Predictive Marker for Steroid Resistance in Immune Checkpoint Inhibitor-related Colitis Open
In immune checkpoint inhibitor (ICI)-related colitis, tumor necrosis factor (TNF)-α blockade is recommended if symptoms are not alleviated with corticosteroids. Although TNF has been shown to be associated with steroid resistance, the earl…
View article: An ACTH-Producing Neuroendocrine Tumor: Clinical Course of Multidisciplinary Therapy Including Peptide Receptor Radionuclide Therapy – A Case Report
An ACTH-Producing Neuroendocrine Tumor: Clinical Course of Multidisciplinary Therapy Including Peptide Receptor Radionuclide Therapy – A Case Report Open
Introduction: Clinical experiences of peptide receptor radionuclide therapy (PRRT) in patients with adrenocorticotropic hormone (ACTH) producing neuroendocrine tumor (NET) were extremely rare. Case Presentation: A 60-year-old woman with hy…
View article: A case of chronic lymphocytic leukemia/small lymphocytic lymphoma diagnosed by skin lesions
A case of chronic lymphocytic leukemia/small lymphocytic lymphoma diagnosed by skin lesions Open
View article: A Case of Repeated Pancreatectomy of a Recurrent Pancreatic Metastases Five Years after the First Resection for Pancreatic Metastasis of Renal Cell Carcinoma
A Case of Repeated Pancreatectomy of a Recurrent Pancreatic Metastases Five Years after the First Resection for Pancreatic Metastasis of Renal Cell Carcinoma Open
View article: Long-term pulmonary repair in rat lungs after sublobar resection: electrocautery versus stapler methods
Long-term pulmonary repair in rat lungs after sublobar resection: electrocautery versus stapler methods Open
Objective We investigated and compared the long-term (6-month) histologic changes in a rat model of sublobar resection created using electrocautery or stapler techniques. Methods Nine-week-old male rats were anesthetized and intubated; tho…
View article: Prognostic significance of immune-cell distribution and tumoral spread through air spaces – Multiplex spatial immunophenotyping analysis–
Prognostic significance of immune-cell distribution and tumoral spread through air spaces – Multiplex spatial immunophenotyping analysis– Open
Immune-cell distribution, particularly CD4, CD8, and FoxP3, is a crucial prognostic factor in lung cancer. STAS and specific immune cell distribution patterns can be used to further stratify patient prognosis. Understanding these interacti…
View article: Exploring LGR5 as a prognostic marker of extrahepatic cholangiocarcinoma: insights from expression analysis and clinical correlations
Exploring LGR5 as a prognostic marker of extrahepatic cholangiocarcinoma: insights from expression analysis and clinical correlations Open
View article: Variability in morphology and immunohistochemistry of Crohn’s disease-associated small bowel neoplasms: implications of Claudin 18 and Cadherin 17 expression for tumor-targeted immunotherapies
Variability in morphology and immunohistochemistry of Crohn’s disease-associated small bowel neoplasms: implications of Claudin 18 and Cadherin 17 expression for tumor-targeted immunotherapies Open
View article: Two Cases of Splenectomy for Portal Hypertension after Living Donor Liver Transplantation
Two Cases of Splenectomy for Portal Hypertension after Living Donor Liver Transplantation Open
門脈圧亢進症は食道胃静脈瘤・脾機能亢進症を来し,内科的治療抵抗性の場合は外科的治療の適応となる.生体肝移植後の肝グラフトに起因する門脈圧亢進症は再移植適応であるが,ドナー不足から困難なことも多い一方,脾摘術の効果は不明である.症例1は25歳の男性で,生後285日に胆道閉鎖症に対し生体肝移植術を受けた.持続する肝機能障害と脾機能亢進症,胃食道静脈瘤を認め門脈圧亢進症と診断し,Hassab手術を施行,肝生検で慢性拒絶が疑われた.症例2は33歳の女性で,15歳時に劇症肝炎に対し生…
View article: Leucine‐rich repeat‐containing G protein‐coupled receptor 5 expression in lymph node metastases of colorectal cancer: Clinicopathological insights and prognostic implications
Leucine‐rich repeat‐containing G protein‐coupled receptor 5 expression in lymph node metastases of colorectal cancer: Clinicopathological insights and prognostic implications Open
Leucine‐rich repeat‐containing G protein‐coupled receptor 5 ( LGR5 ), a significant cancer stem cell marker in colorectal cancer (CRC), lacks lymph node (LN) expression studies. In this study, we identified LGR5 expression by RNAscope, a h…
View article: A preliminary study of IgG4 expression and its prognostic significance in oral squamous cell carcinoma
A preliminary study of IgG4 expression and its prognostic significance in oral squamous cell carcinoma Open
View article: Improving intraoperative diagnosis of spread through air spaces: A cryo-embedding-medium inflation method for frozen section analysis
Improving intraoperative diagnosis of spread through air spaces: A cryo-embedding-medium inflation method for frozen section analysis Open
View article: LGR5 Expression in Lymph Node Metastases of Colorectal Cancer: Clinicopathological Insights and Prognostic Implications
LGR5 Expression in Lymph Node Metastases of Colorectal Cancer: Clinicopathological Insights and Prognostic Implications Open
LGR5 is a promising cancer stem cell marker in colorectal cancer (CRC), and many studies have been conducted on primary tumors. However, LGR5 expression in lymph nodes has not been well studied. In this study, we identified LGR5 expression…
View article: Identification of Terminal βGlcNAc on <i>Brachyspira</i> Species in Human Intestinal Spirochetosis
Identification of Terminal βGlcNAc on <i>Brachyspira</i> Species in Human Intestinal Spirochetosis Open
Human intestinal spirochetosis (HIS) is a colorectal bacterial infection caused by the Brachyspira species. Griffonia simplicifolia-II (GS-II) is a lectin specific to terminal α/βGlcNAc residues. Here, we investigated terminal βGlcNAc resi…
View article: Thrombospondin 2 is a key determinant of fibrogenesis in non‐alcoholic fatty liver disease
Thrombospondin 2 is a key determinant of fibrogenesis in non‐alcoholic fatty liver disease Open
Objective Hepatic overexpression of the thrombospondin 2 gene (THBS2) and elevated levels of circulating thrombospondin 2 (TSP2) have been observed in patients with chronic liver disease. This study aimed to identify the specific cells exp…
View article: An Adult Case of Congenital Portosystemic Shunt with Improvement of Liver Dysfunction after Resection of the Shunting Vessel Concomitantly with Surgery for Gastric Carcinoma
An Adult Case of Congenital Portosystemic Shunt with Improvement of Liver Dysfunction after Resection of the Shunting Vessel Concomitantly with Surgery for Gastric Carcinoma Open
症例はBMI 34の56歳の女性で，既往に2型糖尿病と非アルコール性脂肪性肝疾患が指摘されていた．胃癌の術前精査で肝障害と高アンモニア血症を指摘された．CTでは左胃静脈と左腎静脈を短絡する太い異常血管が認められた．シャント血管の瘤化はなく径は均一で，先天性門脈体循環シャントが示唆された．幽門側胃切除術中に門脈圧を測定したが門脈圧亢進はなく，シャント血管の一時的クランプの前後で圧の大きな上昇を認めなかったため，一期的にシャント血管を切除した．高アンモニア血症は速やかに改善し，…
View article: Thrombospondin 2 is a key determinant of fibrogenesis in NAFLD
Thrombospondin 2 is a key determinant of fibrogenesis in NAFLD Open
Hepatic overexpression of the thrombospondin 2 gene (THBS2) and elevated levels of circulating thrombospondin 2 (TSP2) have been observed in patients with chronic liver disease. The current study aimed to identify the specific cells expres…
View article: ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer
ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer Open
View article: Increased GS‐II lectin binding and SATB2 downregulation are biological features for sessile serrated lesions and microvesicular hyperplastic polyps
Increased GS‐II lectin binding and SATB2 downregulation are biological features for sessile serrated lesions and microvesicular hyperplastic polyps Open
Sessile serrated lesions (SSLs) and microvesicular hyperplastic polyps (MVHPs) are colorectal lesions displaying gastric differentiation. Griffonia simplicifolia ‐II (GS‐II) is a lectin specific to terminal α/βGlcNAc residues. Here, we ass…
View article: Low‐grade mixed neuroendocrine–non‐neuroendocrine neoplasm of the extrahepatic bile duct: A rare tumour with 11 years’ follow‐up before surgery
Low‐grade mixed neuroendocrine–non‐neuroendocrine neoplasm of the extrahepatic bile duct: A rare tumour with 11 years’ follow‐up before surgery Open
Neuroendocrine neoplasms (NENs) in extrahepatic bile ducts are extremely rare, accounting for only 0.2%–2% of NENs.1 In 2010, the World Health Organization proposed the term “mixed adeno-neuroendocrine carcinoma”. However, in 2019 the term…
View article: Clinical features of pagetoid spread: Analysis of perianal lesions associated with anal canal adenocarcinoma and perianal primary extramammary Paget disease
Clinical features of pagetoid spread: Analysis of perianal lesions associated with anal canal adenocarcinoma and perianal primary extramammary Paget disease Open
Secondary extramammary Paget disease (s‐EMPD) represents anal canal and rectal, bladder, and gynecological cancers, which horizontally extend within the epidermis of the anal and vulvar skin. It is necessary to distinguish this condition f…
View article: Surgical revascularization for quasi-moyamoya disease associated with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome: a case report and literature review.
Surgical revascularization for quasi-moyamoya disease associated with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome: a case report and literature review. Open
POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome is a rare multisystem disease characterized by plasma cell dyscrasia and overproduction of vascular endothelial growth factor, which is …
View article: Hereditary diffuse gastric cancer in a Japanese family with CDH1 mutation three case reports
Hereditary diffuse gastric cancer in a Japanese family with CDH1 mutation three case reports Open
View article: ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer
ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer Open
Background: ADP-ribosylation factor-like protein 4C (ARL4C) is a member of the ARF small GTP-binding protein subfamily. The ARL4C gene is highly expressed in colorectal cancer (CRC). ARL4Cprotein promotes cell motility, invasion, and proli…