Mai Honda‐Kitahara
YOU?
Author Swipe
View article: EXTH-58. Long-term treatment with mutant IDH inhibitor DS-1001b suppresses tumor growth and induces epigenetic reprogramming in IDH1-mutant gliomas
EXTH-58. Long-term treatment with mutant IDH inhibitor DS-1001b suppresses tumor growth and induces epigenetic reprogramming in IDH1-mutant gliomas Open
BACKGROUND Heterozygous mutations in isocitrate dehydrogenase (IDH) 1 and 2 represent defining molecular alterations in astrocytoma, IDH-mutant, and oligodendroglioma, IDH-mutant, as classified by the World Health Organization Classificati…
View article: Usefulness of Frameless Neuronavigation–Guided Stereotactic Biopsy for Brain Lesions Under Local Anesthesia: Surgical Outcomes and Feasibility for Molecular Diagnosis—Case Series
Usefulness of Frameless Neuronavigation–Guided Stereotactic Biopsy for Brain Lesions Under Local Anesthesia: Surgical Outcomes and Feasibility for Molecular Diagnosis—Case Series Open
BACKGROUND AND OBJECTIVES: Frameless neuronavigation–guided stereotactic biopsy (SB) is a common surgical technique for diagnosing intracranial lesions. A frameless SB is generally performed under general anesthesia; however, no reports ar…
View article: Utility of [18F]fluciclovine PET/MRI for identifying the optimal biopsy target region, helping to avoid underdiagnosis in patients with glioblastoma: illustrative case
Utility of [18F]fluciclovine PET/MRI for identifying the optimal biopsy target region, helping to avoid underdiagnosis in patients with glioblastoma: illustrative case Open
BACKGROUND Glioblastoma (GBM) is known for its significant intratumoral heterogeneity, making biopsies susceptible to underdiagnosis if samples are taken from less malignant regions. [ 18 F]Fluciclovine, a novel PET tracer, has demonstrate…
View article: Early progressive disease in IDH-mutant grade 2 and 3 astrocytoma without CDKN2A/B homozygous deletions may indicate radiation necrosis
Early progressive disease in IDH-mutant grade 2 and 3 astrocytoma without CDKN2A/B homozygous deletions may indicate radiation necrosis Open
Purpose Isocitrate dehydrogenase (IDH)-mutant astrocytoma without cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) homozygous deletion (HD) typically follows a slow clinical course. However, some cases show early progression on MRI, and t…
View article: Clinical characteristics and prognosis of Glioblastoma patients with infratentorial recurrence
Clinical characteristics and prognosis of Glioblastoma patients with infratentorial recurrence Open
Background Glioblastoma (GBM) infrequently recurs in the infratentorial region. Such Infratentorial recurrence (ITR) has some clinically unique characteristics, such as presenting unspecific symptoms and providing patients a chance to rece…
View article: Bevacizumab beyond Progression for Newly Diagnosed Glioblastoma (BIOMARK): Phase II Safety, Efficacy and Biomarker Study
Bevacizumab beyond Progression for Newly Diagnosed Glioblastoma (BIOMARK): Phase II Safety, Efficacy and Biomarker Study Open
We evaluated the efficacy and safety of bevacizumab beyond progression (BBP) in Japanese patients with newly diagnosed glioblastoma and explored predictors of response to bevacizumab. This phase II study evaluated a protocol-defined primar…
View article: Volumetric Analysis of Glioblastoma for Determining Which CpG Sites Should Be Tested by Pyrosequencing to Predict Temozolomide Efficacy
Volumetric Analysis of Glioblastoma for Determining Which CpG Sites Should Be Tested by Pyrosequencing to Predict Temozolomide Efficacy Open
The aim of the present study was to determine which individual or combined CpG sites among O6-methylguanine DNA methyltransferase CpG 74–89 in glioblastoma mainly affects the response to temozolomide resulting from CpG methylation using st…
View article: Clinical characteristics and prognosis of patients with glioblastoma with infratentorial leptomeningeal dissemination
Clinical characteristics and prognosis of patients with glioblastoma with infratentorial leptomeningeal dissemination Open
Background Leptomeningeal dissemination (LMD) is a severe complication of glioblastoma (GBM) and has become a more common and indispensable clinical proposition with improved patient prognosis. Although infratentorial leptomeningeal dissem…
View article: Clinical characteristics and prognosis of patients with glioblastoma with infratentorial leptomeningeal dissemination
Clinical characteristics and prognosis of patients with glioblastoma with infratentorial leptomeningeal dissemination Open
Objective Leptomeningeal dissemination (LMD) is a severe complication of glioblastoma (GBM) and has become a more common and indispensable clinical proposition with improved patient prognosis. Although infratentorial leptomeningeal dissemi…
View article: MGMT gene promoter methylation by pyrosequencing method correlates volumetric response and neurological status in IDH wild-type glioblastomas
MGMT gene promoter methylation by pyrosequencing method correlates volumetric response and neurological status in IDH wild-type glioblastomas Open
View article: Clinical Characteristics and Prognosis of Patients with Glioblastoma with Infratentorial Leptomeningeal Dissemination
Clinical Characteristics and Prognosis of Patients with Glioblastoma with Infratentorial Leptomeningeal Dissemination Open
Objective: Leptomeningeal dissemination (LMD) is a severe complication of glioblastoma (GBM) and has become a more common and indispensable clinical proposition with improved patient prognosis. Although infratentorial leptomeningeal dissem…
View article: MGMT Gene Promoter Methylation by Pyrosequencing Method Correlates Volumetric Response and Neurological Status in IDH Wild-type Glioblastomas
MGMT Gene Promoter Methylation by Pyrosequencing Method Correlates Volumetric Response and Neurological Status in IDH Wild-type Glioblastomas Open
Purpose Although the usefulness of O⁶-methylguanine DNA methyltransferase (MGMT) promoter methylation analysis for predicting response to chemoradiotherapy and the prognosis of patients with glioblastoma has been widely reported, there is …
View article: The clinical characteristics and outcomes of incidentally discovered glioblastoma
The clinical characteristics and outcomes of incidentally discovered glioblastoma Open
View article: The Clinical Characteristics and Outcomes of Incidentally Discovered Glioblastoma
The Clinical Characteristics and Outcomes of Incidentally Discovered Glioblastoma Open
Objective With an increase in the number of imaging examinations and the development of imaging technology, a small number of glioblastomas (GBMs) are identified by incidental radiological images. These incidentally discovered glioblastoma…
View article: The ALK inhibitors, alectinib and ceritinib, induce ALK‐independent and STAT3‐dependent glioblastoma cell death
The ALK inhibitors, alectinib and ceritinib, induce ALK‐independent and STAT3‐dependent glioblastoma cell death Open
Glioblastoma (GBM) is the most common, but extremely malignant, brain tumor; thus, the development of novel therapeutic strategies for GBMs is imperative. Many tyrosine kinase inhibitors (TKIs) have been approved for various cancers, yet n…
View article: Publications from Juntendo University Graduate School of Medicine, 2018 [2/6]
Publications from Juntendo University Graduate School of Medicine, 2018 [2/6] Open
View article: Absence of H3F3A mutation in a subset of malignant giant cell tumor of bone
Absence of H3F3A mutation in a subset of malignant giant cell tumor of bone Open
View article: Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors
Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors Open
View article: Additional file 5: of Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors
Additional file 5: of Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors Open
Table S4. RNA sequencing results (XLSX 51 kb)
View article: Additional file 3: of Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors
Additional file 3: of Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors Open
Table S3. List of cases (XLSX 66 kb)
View article: Additional file 1: of Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors
Additional file 1: of Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors Open
Table S1. Primer sequences and pyrosequencing assays (XLSX 14 kb)
View article: Additional file 2: of Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors
Additional file 2: of Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors Open
Table S2. Candidate probes in screening set for pyrosequencing assay (XLSX 11 kb)
View article: Fold-change detection and scale invariance of cell–cell signaling in social amoeba
Fold-change detection and scale invariance of cell–cell signaling in social amoeba Open
Significance Recent works have hinted at an ability of cells to respond in the exact same manner to a fold change in the input stimulus. The property is thought to allow cells to function properly regardless of changes in the absolute conc…