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View article: Supplemental Tables from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells
Supplemental Tables from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells Open
Supplemental Table 1 shows patients distribution in OC cohorts from Stanford University. Supplemental Table 2 shows primers for mutagenesis. Supplemental Table 3 shows primers for real-time PCR. Supplemental Table 4 shows gene mutations id…
View article: Supplemental Figure 6 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells
Supplemental Figure 6 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells Open
CB-839 overcomes RT resistance in Nrf2E79Q MOC1 cells through regulating the tumor microenvironment.
View article: Supplemental Figure 7 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells
Supplemental Figure 7 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells Open
CB-839 overcomes the Nrf2E79Q-induced radiation resistance through regulating TLR4-mediated cytokine changes.
View article: Supplementary Figure 4 from Galectin-1 Mediates Chronic STING Activation in Tumors to Promote Metastasis through MDSC Recruitment
Supplementary Figure 4 from Galectin-1 Mediates Chronic STING Activation in Tumors to Promote Metastasis through MDSC Recruitment Open
A. Gating strategy for CD8+ T cells in the spleen of mice treated with either MOC2 WT/KO-Gal1 CM. B. Quantitation of PMN-MDSCs and T cells in the spleen of mice bearing KO-Gal1 tumors injected with either WT- or KO-Gal1 CM for 3 weeks. C. …
View article: Supplementary Figure 1 from Galectin-1 Mediates Chronic STING Activation in Tumors to Promote Metastasis through MDSC Recruitment
Supplementary Figure 1 from Galectin-1 Mediates Chronic STING Activation in Tumors to Promote Metastasis through MDSC Recruitment Open
A. Terminal Tumor volume of MOC2 WT/KO-Gal1 tumors in Rag2-/- IL2rg-/- mice. B. Gating strategy used for analyses of PMN-MDSCs and M-MDSCs in tumor and lung tissues. C. Unsupervised tSNE clustering of live cells in MOC2 WT/KO-Gal1 tumor sh…
View article: Supplemental Figure 1 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells
Supplemental Figure 1 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells Open
Mutational landscape and details of NFE2L2 gene mutation in a cohort of oral cavity cancer patients treated with surgery and postoperative (chemo)radiotherapy at Stanford University.
View article: Supplemental Figure 4 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells
Supplemental Figure 4 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells Open
NFE2L2 mutation leads to extrinsic radiation resistance.
View article: Supplementary Figure Legends from Galectin-1 Mediates Chronic STING Activation in Tumors to Promote Metastasis through MDSC Recruitment
Supplementary Figure Legends from Galectin-1 Mediates Chronic STING Activation in Tumors to Promote Metastasis through MDSC Recruitment Open
sh-RNA knockdown sequences used in the study
View article: Supplementary Figure 6 from Galectin-1 Mediates Chronic STING Activation in Tumors to Promote Metastasis through MDSC Recruitment
Supplementary Figure 6 from Galectin-1 Mediates Chronic STING Activation in Tumors to Promote Metastasis through MDSC Recruitment Open
Immunoblot showing knockdown of STING in MOC2 WT/KO cells.
View article: Supplemental Figure 3 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells
Supplemental Figure 3 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells Open
Somatic mutation of NFE2L2 leads to Nrf2 activation and promotes intrinsic radiation resistance in human head and neck squamous cell carcinoma (HNSCC).
View article: Supplemental Figure 5 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells
Supplemental Figure 5 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells Open
Nrf2 mutation leads to extrinsic radiation resistance through recruitment of PMN-MDSC in tumors.
View article: Targeting C5aR1 Reveals Protective Macrophage Maturation States in Intestinal Injury
Targeting C5aR1 Reveals Protective Macrophage Maturation States in Intestinal Injury Open
Inflammatory intestinal injury, which may occur following cytotoxic cancer treatments such as radiotherapy, compromises homeostasis when intestinal stem cells undergo apoptosis and regeneration programmes are not effectively engaged. Recen…
View article: Association of life’s crucial 9 and gallstone disease in United States adults compared to life’s essential 8: NHANES 2017-2018
Association of life’s crucial 9 and gallstone disease in United States adults compared to life’s essential 8: NHANES 2017-2018 Open
Objective: Cardiovascular health (CVH) represents a composite measure of key lifestyle behaviors and physiological factors. Life’s Essential 8 (LE8) quantifies eight domains of CVH, while Life’s Crucial 9 (LC9) extends this framework by in…
View article: 671 Gold-siRNA supracluster targeting galectin-1 to enhance immuno-radiotherapy
671 Gold-siRNA supracluster targeting galectin-1 to enhance immuno-radiotherapy Open
View article: Outcomes Of Homograft Pulmonary Valve Replacement At Viet Duc University Hospital
Outcomes Of Homograft Pulmonary Valve Replacement At Viet Duc University Hospital Open
Introduction: Pulmonary valve disease is the least common of valvular heart diseases and is primarily associated with congenital heart diseases such as pulmonary valve stenosis, pulmonary valve atresia with ventricular septal defect, tetra…
View article: From Local to Global: Revisiting Structured Pruning Paradigms for Large Language Models
From Local to Global: Revisiting Structured Pruning Paradigms for Large Language Models Open
Structured pruning is a practical approach to deploying large language models (LLMs) efficiently, as it yields compact, hardware-friendly architectures. However, the dominant local paradigm is task-agnostic: by optimizing layer-wise recons…
View article: Cerebral mycotic aneurysm with internal carotid artery occlusion: a case description
Cerebral mycotic aneurysm with internal carotid artery occlusion: a case description Open
View article: Development and Validation of a Digital Pathology-Based, Multimodal Artificial Intelligence (MMAI) Biomarker in Patients with Head and Neck Cancer
Development and Validation of a Digital Pathology-Based, Multimodal Artificial Intelligence (MMAI) Biomarker in Patients with Head and Neck Cancer Open
View article: Discovery of potent inhibitors of NS4B protein of dengue virus type 2 from natural compounds: an in silico approach
Discovery of potent inhibitors of NS4B protein of dengue virus type 2 from natural compounds: an in silico approach Open
Dengue fever is an annual infectious epidemic disease caused by the Dengue virus, mainly found in tropical and subtropical regions. Of which, Dengue virus type 2 (DENV2) has been a major cause of severe cases globally. Currently, NS4B is o…
View article: Automated radiotherapy treatment planning guided by GPT-4Vision
Automated radiotherapy treatment planning guided by GPT-4Vision Open
Objective . Radiotherapy treatment planning is a time-consuming and potentially subjective process that requires iterative adjustment of model parameters to balance multiple conflicting objectives. Recent advancements in frontier artificia…
View article: Phase 2 Study of Low-Dose Paclitaxel and Cisplatin in Combination With Split-Course Concomitant Twice-Daily Reirradiation in Recurrent Squamous Cell Carcinoma of the Head and Neck: Long-term Follow-up of NRG Oncology Radiation Therapy Oncology Group Protocol 9911
Phase 2 Study of Low-Dose Paclitaxel and Cisplatin in Combination With Split-Course Concomitant Twice-Daily Reirradiation in Recurrent Squamous Cell Carcinoma of the Head and Neck: Long-term Follow-up of NRG Oncology Radiation Therapy Oncology Group Protocol 9911 Open
Despite a high incidence of grade 5 toxicity, OS rates for this trial evaluating concurrent split course twice a day reirradiation with cisplatin and paclitaxel exceeded results seen historically with chemotherapy alone.
View article: VISTA immune checkpoint blunts radiotherapy-induced antitumor immune response
VISTA immune checkpoint blunts radiotherapy-induced antitumor immune response Open
Radiotherapy (RT) is a key treatment for solid neoplasms like head and neck cancer (HNC), but it can also activate and recruit immunosuppressive myeloid cells, causing treatment failure. In this study, we examine the role of V-domain immun…
View article: The RNA demethylase FTO promotes glutamine metabolism in clear cell renal cell carcinoma through the regulation of SLC1A5
The RNA demethylase FTO promotes glutamine metabolism in clear cell renal cell carcinoma through the regulation of SLC1A5 Open
Glutamine reprogramming plays a crucial role in the growth and survival of clear cell renal cell carcinoma (ccRCC), although the mechanisms governing its regulation are still not fully understood. We demonstrate that the RNA demethylase fa…
View article: FTO inhibition enhances the therapeutic index of radiation therapy in head and neck cancer
FTO inhibition enhances the therapeutic index of radiation therapy in head and neck cancer Open
Despite aggressive chemoradiation treatment, the overall survival rate for patients with HPV- head and neck squamous cell carcinoma (HNSCC) remains poor, highlighting the urgent need for more effective drug-radiotherapy combinations to imp…
View article: Evaluation of Bioactivity Effects of <i>Paramignya trimera</i> in the Treatment of Lung Cancer through <i>In Silico</i> Approaches
Evaluation of Bioactivity Effects of <i>Paramignya trimera</i> in the Treatment of Lung Cancer through <i>In Silico</i> Approaches Open
The present study is an attempt to evaluate the bioactivity effects of the Paramignya trimera (P. trimera) extract using in silico approaches. Network pharmacology was initially applied to identify potential pathways and key targets…
View article: O-187 Individualized luteal phase support with intramuscular progesterone in patients with low serum progesterone on the day of frozen-thawed embryo transfer: a randomized clinical trial
O-187 Individualized luteal phase support with intramuscular progesterone in patients with low serum progesterone on the day of frozen-thawed embryo transfer: a randomized clinical trial Open
Study question Does the addition of intramuscular progesterone improve frozen embryo transfer (FET) outcomes in patients with low serum progesterone levels on the day of embryo transfer? Summary answer Supplementing with intramuscular prog…
View article: Sjögren’s Syndrome–Associated Fulminant Myocarditis Presenting as Cardiogenic Shock Requiring VA-ECMO: A Case Report
Sjögren’s Syndrome–Associated Fulminant Myocarditis Presenting as Cardiogenic Shock Requiring VA-ECMO: A Case Report Open
Fulminant autoimmune myocarditis is a rare but life-threatening condition that can present as the initial manifestation of an underlying autoimmune disease. Early recognition and prompt initiation of mechanical circulatory support and immu…
View article: International Consensus Guideline on Delineation of the Clinical Target Volumes at Different Dose Levels for Nasopharyngeal Carcinoma (2024 Version)
International Consensus Guideline on Delineation of the Clinical Target Volumes at Different Dose Levels for Nasopharyngeal Carcinoma (2024 Version) Open
Amidst the challenges of diverging practices, a comprehensive consensus guideline has been devised based on updated evidence and collective agreement among international experts. This serves as a practical reference for optimal target cove…
View article: Improved detection and localization of insulinoma using small field-of-view diffusion-weighted MRI: A case report
Improved detection and localization of insulinoma using small field-of-view diffusion-weighted MRI: A case report Open
View article: MONTAGE: A Computation Framework to Identify Spatially Resolved Functional Enrichment Gradients in the Tissue Microenvironment via Spatial Communities
MONTAGE: A Computation Framework to Identify Spatially Resolved Functional Enrichment Gradients in the Tissue Microenvironment via Spatial Communities Open
Single-cell spatial-omics has advanced our understanding of how tumor microenvironment contributes to cancer progression. However, most single-cell spatial-omics studies focus on cell types and neighborhoods, offering limited information a…