Maia Merabishvili
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View article: Phage Therapy for Orthopaedic Infections: The First Three Cases from the United Kingdom
Phage Therapy for Orthopaedic Infections: The First Three Cases from the United Kingdom Open
Background: Bacteriophages (phages) are viruses that infect and kill bacteria. The antimicrobial resistance crisis has driven renewed interest in phage therapy, including the use of phages to treat chronic orthopaedic infections. Methods: …
View article: Bacteriophage ISP eliminates Staphylococcus aureus in planktonic phase, but not in the various stages of the biofilm cycle
Bacteriophage ISP eliminates Staphylococcus aureus in planktonic phase, but not in the various stages of the biofilm cycle Open
View article: Bacteriophages for the treatment of pseudomonas-infected vascular prosthesis
Bacteriophages for the treatment of pseudomonas-infected vascular prosthesis Open
We present a case report detailing therapeutic application of two lytic antipseudomonal bacteriophages to treat a chronic relapsing Pseudomonas aeruginosa infection of a prosthetic aortic graft. As there are currently no Danish laboratorie…
View article: Characterization of a Bacteriophage GEC_vB_Bfr_UZM3 Active against Bacteroides fragilis
Characterization of a Bacteriophage GEC_vB_Bfr_UZM3 Active against Bacteroides fragilis Open
Bacteroides fragilis is a commensal gut bacterium that is associated with a number of blood and tissue infections. It has not yet been recognized as one of the drug-resistant human pathogens, but cases of the refractory infections, caused …
View article: Screening of Anorectal and Oropharyngeal Samples Fails to Detect Bacteriophages Infecting Neisseria gonorrhoeae
Screening of Anorectal and Oropharyngeal Samples Fails to Detect Bacteriophages Infecting Neisseria gonorrhoeae Open
There are real concerns that Neisseria gonorrhoeae may become untreatable in the near future due to the rapid emergence of antimicrobial resistance. Alternative therapies are thus urgently required. Bacteriophages active against N. gonorrh…
View article: Bacteriophage Therapy for Difficult-to-Treat Infections: The Implementation of a Multidisciplinary Phage Task Force (The PHAGEFORCE Study Protocol)
Bacteriophage Therapy for Difficult-to-Treat Infections: The Implementation of a Multidisciplinary Phage Task Force (The PHAGEFORCE Study Protocol) Open
In times where only a few novel antibiotics are to be expected, antimicrobial resistance remains an expanding global health threat. In case of chronic infections caused by therapy-resistant pathogens, physicians have limited therapeutic op…
View article: P084 Screening of anorectal and oropharyngeal samples fails to detect bacteriophages infecting Neisseria gonorrhoeae
P084 Screening of anorectal and oropharyngeal samples fails to detect bacteriophages infecting Neisseria gonorrhoeae Open
Background There are real concerns that Neisseria gonorrhoeae may become untreatable in the near future due to the rapid emergence of antimicrobial resistance. Alternative therapies are thus urgently required. Bacteriophages active against…
View article: A Case of Phage Therapy against Pandrug-Resistant Achromobacter xylosoxidans in a 12-Year-Old Lung-Transplanted Cystic Fibrosis Patient
A Case of Phage Therapy against Pandrug-Resistant Achromobacter xylosoxidans in a 12-Year-Old Lung-Transplanted Cystic Fibrosis Patient Open
Bacteriophages are a promising therapeutic strategy among cystic fibrosis and lung-transplanted patients, considering the high frequency of colonization/infection caused by pandrug-resistant bacteria. However, little clinical data are avai…
View article: Characterization of Salmonella Isolates from Various Geographical Regions of the Caucasus and Their Susceptibility to Bacteriophages
Characterization of Salmonella Isolates from Various Geographical Regions of the Caucasus and Their Susceptibility to Bacteriophages Open
Non-typhoidal Salmonella present a major threat to animal and human health as food-borne infectious agents. We characterized 91 bacterial isolates from Armenia and Georgia in detail, using a suite of assays including conventional microbiol…
View article: Bacteriophages as potential controlling agents against cholera in the Democratic Republic of Congo (DRC)
Bacteriophages as potential controlling agents against cholera in the Democratic Republic of Congo (DRC) Open
View article: The Unique Role That WHO Could Play in Implementing Phage Therapy to Combat the Global Antibiotic Resistance Crisis
The Unique Role That WHO Could Play in Implementing Phage Therapy to Combat the Global Antibiotic Resistance Crisis Open
OPINION article Front. Microbiol., 03 September 2020Sec. Antimicrobials, Resistance and Chemotherapy Volume 11 - 2020 | https://doi.org/10.3389/fmicb.2020.01982
View article: Bacteriophage Application for Difficult-To-Treat Musculoskeletal Infections: Development of a Standardized Multidisciplinary Treatment Protocol
Bacteriophage Application for Difficult-To-Treat Musculoskeletal Infections: Development of a Standardized Multidisciplinary Treatment Protocol Open
Bacteriophage therapy has recently attracted increased interest, particularly in difficult-to-treat infections. Although it is not a novel concept, standardized treatment guidelines are currently lacking. We present the first steps towards…
View article: Phage typing, antibiotic resistance and genomic rep-PCR fingerprinting of clinical Salmonella isolates from the Caucasus region
Phage typing, antibiotic resistance and genomic rep-PCR fingerprinting of clinical Salmonella isolates from the Caucasus region Open
Background: In reaction to the use of antibiotics in farming and veterinary practices, MDR phenotypes have emerged. As Salmonella enterica serovars are widely diverse and spread through the food chain, rapid increase in antibiotic resistan…
View article: Could bacteriophages help with managing cholera in The Democratic Republic of Congo (DRC)?
Could bacteriophages help with managing cholera in The Democratic Republic of Congo (DRC)? Open
International audience
View article: Development of a transportable single-use biomanufacturing system for therapeutic phage preparations
Development of a transportable single-use biomanufacturing system for therapeutic phage preparations Open
Background: The worldwide antibiotic crisis has led to a renewed interest in phage therapy. Lytic phages against bacterial pathogens can be isolated from the environment or selected from a collection in a matter of days. Product discovery …
View article: Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains
Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains Open
Phage therapy is increasingly put forward as a “new” potential tool in the fight against antibiotic resistant infections. During the “Centennial Celebration of Bacteriophage Research” conference in Tbilisi, Georgia on 26–29 June 2017, an i…
View article: Staphylococcus aureus controls interleukin-5 release in upper airway inflammation
Staphylococcus aureus controls interleukin-5 release in upper airway inflammation Open
View article: Stability of bacteriophages in burn wound care products
Stability of bacteriophages in burn wound care products Open
Bacteriophages could be used along with burn wound care products to enhance antimicrobial pressure during treatment. However, some of the components of the topical antimicrobials that are traditionally used for the prevention and treatment…
View article: Use of bacteriophages in the treatment of colistin-only-sensitive Pseudomonas aeruginosa septicaemia in a patient with acute kidney injury—a case report
Use of bacteriophages in the treatment of colistin-only-sensitive Pseudomonas aeruginosa septicaemia in a patient with acute kidney injury—a case report Open
View article: Molecular Epidemiology and Clinical Impact of Acinetobacter calcoaceticus-baumannii Complex in a Belgian Burn Wound Center
Molecular Epidemiology and Clinical Impact of Acinetobacter calcoaceticus-baumannii Complex in a Belgian Burn Wound Center Open
Multidrug resistant Acinetobacter baumannii and its closely related species A. pittii and A. nosocomialis, all members of the Acinetobacter calcoaceticus-baumannii (Acb) complex, are a major cause of hospital acquired infection. In the bur…
View article: A bacteriophage journey at the European Medicines Agency
A bacteriophage journey at the European Medicines Agency Open
The seriously and globally increasing bacterial multi-drug resistance calls out on concerted counteractive measures: international health authorities give consideration to the therapeutical use of bacteriophage therapy.
View article: Pre‐adapting parasitic phages to a pathogen leads to increased pathogen clearance and lowered resistance evolution with <i>Pseudomonas aeruginosa</i> cystic fibrosis bacterial isolates
Pre‐adapting parasitic phages to a pathogen leads to increased pathogen clearance and lowered resistance evolution with <i>Pseudomonas aeruginosa</i> cystic fibrosis bacterial isolates Open
Recent years have seen renewed interest in phage therapy – the use of viruses to specifically kill disease‐causing bacteria – because of the alarming rise in antibiotic resistance. However, a major limitation of phage therapy is the ease a…
View article: Unexploited opportunities for phage therapy
Unexploited opportunities for phage therapy Open
This opinion article reports on a number of bacterial pathogens for which virulent phages can still be isolated but till now have been neglected due to various reasons listed below.
View article: Quality and Safety Requirements for Sustainable Phage Therapy Products
Quality and Safety Requirements for Sustainable Phage Therapy Products Open