Maico Lechner
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View article: Comparative Analysis of Lysine-Specific Peptidases for Optimizing Proteomics Workflows
Comparative Analysis of Lysine-Specific Peptidases for Optimizing Proteomics Workflows Open
This study presents a comparative analysis of three LysC endopeptidase homologues from Achromobacter lyticus (A. lyticus),Pseudomonas aeruginosa and Lysobacter enzymogenes for mass spectrometry-based proteomics. Utilizing a protein aggrega…
View article: Single-cell proteomics of pancreatic islet cells reveals type 1 diabetes and donor-specific features
Single-cell proteomics of pancreatic islet cells reveals type 1 diabetes and donor-specific features Open
Type 1 diabetes mellitus (T1DM) is the most common severe chronic disease in children and adolescents and requires life-long exogenous insulin treatment. Investigating key differences between the pancreas of healthy and T1DM patients is ke…
View article: Formaldehyde Fixation Helps Preserve the Proteome State during Single-Cell Proteomics Sample Processing and Analysis
Formaldehyde Fixation Helps Preserve the Proteome State during Single-Cell Proteomics Sample Processing and Analysis Open
Mass spectrometry-based single-cell proteomics (SCP) is gaining momentum but remains limited to a few laboratories due to the high costs and specialized expertise required. The ability to send samples to specialized core facilities would b…
View article: Comparative Analysis of Lysine-Specific Peptidases for Optimizing Proteomics Workflows
Comparative Analysis of Lysine-Specific Peptidases for Optimizing Proteomics Workflows Open
This study presents a comparative analysis of three LysC homologues from Achromobacter lyticus, Pseudomonas aeruginosa, and Lysobacter enzymogenes for mass spectrometry-based proteomics. Utilizing a protein aggregation capture (PAC) workfl…
View article: Global analysis of protein turnover dynamics in single cells
Global analysis of protein turnover dynamics in single cells Open
Even with recent improvements in sample preparation and instrumentation, single-cell proteomics (SCP) analyses mostly measure protein abundances, making the field unidimensional. In this study, we employ a pulsed stable isotope labeling by…
View article: One-Tip enables comprehensive proteome coverage in minimal cells and single zygotes
One-Tip enables comprehensive proteome coverage in minimal cells and single zygotes Open
Mass spectrometry (MS)-based proteomics workflows typically involve complex, multi-step processes, presenting challenges with sample losses, reproducibility, requiring substantial time and financial investments, and specialized skills. Her…