Maike Heppelmann
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Hock Lesions, Cow Hygiene, and Compost Quality in Compost-Bedded Pack Barns in Germany Open
The aim of the study was to evaluate the prevalence of hock lesions and cow hygiene as a cross-sectional study in dairy cows housed in compost-bedded pack barns (CBPs) in southern Germany. The effects of season, compost variables, and hous…
View article: Spina bifida, diplomyelia, and Chiari-like malformation in an Aberdeen Angus calf
Spina bifida, diplomyelia, and Chiari-like malformation in an Aberdeen Angus calf Open
Background Spina bifida and Chiari-like malformation are rare congenital anomalies resulting in severe neurological signs in calves. The cause is unclear, but genetic and environmental factors are thought to play a role. Case presentation …
View article: Gene profiles of peripheral white blood cells as potential predictors of pregnancy in embryo-recipient heifers
Gene profiles of peripheral white blood cells as potential predictors of pregnancy in embryo-recipient heifers Open
The bovine endometrium undergoes cellular, molecular, and functional changes to support embryo survival and development to term. These changes involve a finely coordinated series of events at both local and systemic levels. We postulated t…
Invited review: Development of a dairy barn concept to improve animal welfare Open
Owing to political and societal requirements, farmers are required to produce animal-friendly and sustainable products in an economic manner. Investments have been made to improve housing conditions for farm animals such as cattle, but fur…
The Effect of Compost-Bedded Pack Barns on Claw Health and Lameness in Dairy Herds in Southern Germany Open
The aim of this study was to determine claw health and lameness prevalence in cows housed in CBPs in southern Germany. Eight farms that housed their dairy cows in CBPs were visited for data collection once in the warm season and once in th…
View article: A Missense Mutation in the Collagen Triple Helix of EDA Is Associated with X-Linked Recessive Hypohidrotic Ectodermal Dysplasia in Fleckvieh Cattle
A Missense Mutation in the Collagen Triple Helix of EDA Is Associated with X-Linked Recessive Hypohidrotic Ectodermal Dysplasia in Fleckvieh Cattle Open
Mutations within the ectodysplasin A (EDA) gene have been associated with congenital hypotrichosis and anodontia (HAD/XHED) in humans, mice, dogs and cattle. We identified a three-generation family of Fleckvieh cattle with male calves exhi…
Simulator-Assisted Training of Abomasal Surgery—A Pilot Study Using Blended Learning and Face-to-Face Teaching Open
Two stimulators were developed, one simplified and one realistic, in the present study for learning abomasal surgery for veterinary students. The simulators were tested in a pilot study: The upcoming blended learning format was compared wi…
Effect of Different Thawing Methods for Frozen Bull Semen and Additional Factors on the Conception Rate of Dairy Cows in Artificial Insemination Open
Recommendations for thawing methods of frozen bovine semen vary and clear data evaluating their influence on fertility are contradictory. In this respect, the aim of this study was to investigate the influence of different thawing methods …
Prevalence and Risk Factors for ESBL/AmpC-E. coli in Pre-Weaned Dairy Calves on Dairy Farms in Germany Open
The objectives of this study were to ascertain the fecal ESBL/AmpC-E. coli prevalence and to detect risk factors for their occurrence in young pre-weaned calves and their dams on large dairy farms in Germany. From 2018–2019 we investigated…
In vitro effects of lipopolysaccharides on bovine uterine contractility Open
Metritis is an important disorder in dairy cows during the early postpartum period. Myometrial contractility is a prerequisite for uterine involution; however, very scanty literature is available about the effect of metritis on this proces…
Clinical, cytogenetic and molecular genetic characterization of a tandem fusion translocation in a male Holstein cattle with congenital hypospadias and a ventricular septal defect Open
Hypospadias, disorder of sex development (DSD), is a sporadic congenital abnormality of the genital region in male ruminants, which is characterized by a non-fused urethra during fetal development. Detailed clinical examination classified …
Study of congenital Morgagnian cataracts in Holstein calves Open
Cataracts are focal to diffuse opacities of the eye lens causing impaired vision or complete blindness. For bilateral congenital cataracts in Red Holsteins a perfectly cosegregating mutation within the CPAMD8 gene (CPAMD8:g.5995966C>T) has…
View article: Subclinical endometritis in dairy cattle is associated with distinct mRNA expression patterns in blood and endometrium
Subclinical endometritis in dairy cattle is associated with distinct mRNA expression patterns in blood and endometrium Open
Cattle with subclinical endometritis (SCE) are sub-fertile and diagnosing subclinical uterine disease remains a challenge. The hypothesis for this study was that endometrial inflammation is reflected in mRNA expression patterns of peripher…
View article: TLR2/4 signaling pathway mediates sperm-induced inflammation in bovine endometrial epithelial cells in vitro
TLR2/4 signaling pathway mediates sperm-induced inflammation in bovine endometrial epithelial cells in vitro Open
We have recently shown that sperm attachment to bovine endometrial epithelial cells (BEECs) triggers uterine local innate immunity with induction of a pro-inflammatory response in vitro, however details of the mechanism remain unknown. Her…
Comparison Between K3EDTA and Lithium Heparin as Anticoagulant to Isolate Bovine Granulocytes From Blood Open
Granulocytes play a key role in the defense against invading pathogens. To study granulocyte functions, the isolation of a pure and active cell population from fresh blood is required. Anticoagulants and red blood cells (RBCs) lysis used i…
Curly coat caused by a <i>keratin 27</i> variant was transmitted from Fleckvieh into German Angus Open
The most common coat type in cattle is short, straight hair. Curly coat was described in Swedish Cattle, Ayrshire, German Fleckvieh (GF) and Montbéliarde with an autosomal dominant pattern of heredity.1-3 A sequence-based association study…
View article: Short communication: Pilot study on hormonal, metabolic, and behavioral stress response to treatment of claw horn lesions in acutely lame dairy cows
Short communication: Pilot study on hormonal, metabolic, and behavioral stress response to treatment of claw horn lesions in acutely lame dairy cows Open
Short-term effects of therapeutic claw trimming in acutely lame cows (n=21) with nonadvanced claw horn lesions on the endocrine, metabolic, and behavioral stress responses were investigated in comparison to regular claw trimming in nonlame…
Clinical and subclinical endometritis induced alterations in bovine endometrial transcriptome and miRNome profile Open
The results of this study unraveled endometrial transcriptome and miRNome profile alterations in cows affected by subclinical or clinical endometritis which may have a significant effect on the uterine homeostasis and uterine receptivity.
Additional file 1: Table S1. of Clinical and subclinical endometritis induced alterations in bovine endometrial transcriptome and miRNome profile Open
The list of differentially expressed genes between CE and HE animals along with their fold change, p values and FDR. (XLSX 31 kb)
Additional file 2: Table S2. of Clinical and subclinical endometritis induced alterations in bovine endometrial transcriptome and miRNome profile Open
The list of differentially expressed genes between SE and HE animals along with their fold change, p values and FDR. (XLSX 12 kb)
Additional file 4: Table S3. of Clinical and subclinical endometritis induced alterations in bovine endometrial transcriptome and miRNome profile Open
The list of differentially expressed miRNAs between SE and HE animal groups. (XLSX 12 kb)