Maike Roas
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Targeting FLT3 with a new-generation antibody-drug conjugate in combination with kinase inhibitors for treatment of AML Open
Fms-like tyrosine kinase 3 (FLT3) is often overexpressed or constitutively activated by internal tandem duplication (ITD) and tyrosine kinase domain (TKD) mutations in acute myeloid leukemia (AML). Despite the use of receptor tyrosine kina…
View article: The <scp>EMT</scp> transcription factor <scp>ZEB1</scp> blocks osteoblastic differentiation in bone development and osteosarcoma
The <span>EMT</span> transcription factor <span>ZEB1</span> blocks osteoblastic differentiation in bone development and osteosarcoma Open
Osteosarcoma is an often‐fatal mesenchyme‐derived malignancy in children and young adults. Overexpression of EMT‐transcription factors (EMT‐TFs) has been associated with poor clinical outcome. Here, we demonstrated that the EMT‐TF ZEB1 is …