Mailton Vasconcelos
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View article: A shedding analysis after AAV8 CNS injection revealed fragmented viral DNA without evidence of functional AAV particles in mice
A shedding analysis after AAV8 CNS injection revealed fragmented viral DNA without evidence of functional AAV particles in mice Open
Adeno-associated viruses (AAV) are commonly used in the scientific field due to their diverse application range. However, AAV shedding, the release of virions from the host organism, can impact the safety of AAV-based approaches. An increa…
View article: A shedding analysis after AAV8 CNS injection revealed fragmented viral DNA without evidence of functional AAV particles in mice.
A shedding analysis after AAV8 CNS injection revealed fragmented viral DNA without evidence of functional AAV particles in mice. Open
Adeno-associated viruses (AAV) are commonly used in the scientific field due to their diverse application range. However, AAV-shedding, the release of virions from the host organism, can impact the safety of AAV-based approaches. An increa…
View article: Reliability of Point-of-Collection Testing Devices for Cannabinoid Detection in Oral Fluid
Reliability of Point-of-Collection Testing Devices for Cannabinoid Detection in Oral Fluid Open
View article: Behavioral manifestations in rodent models of autism spectrum disorder: protocol for a systematic review and network meta-analysis
Behavioral manifestations in rodent models of autism spectrum disorder: protocol for a systematic review and network meta-analysis Open
View article: Projeto Drogômetros: avaliação da usabilidade de dispositivos de detecção de substâncias psicoativas em amostras de fluido oral no trânsito brasileiro
Projeto Drogômetros: avaliação da usabilidade de dispositivos de detecção de substâncias psicoativas em amostras de fluido oral no trânsito brasileiro Open
View article: Corticotropin-releasing factor receptor signaling and modulation: implications for stress response and resilience
Corticotropin-releasing factor receptor signaling and modulation: implications for stress response and resilience Open
Introduction In addition to their role in regulation of the hypothalamic-pituitary-adrenal-axis, corticotropin-releasing factor (CRF) and its related peptides, the urocortins, are important mediators of physiological and pathophysiological…
View article: Role of CRF receptor 1 antagonism in the bed nucleus of the stria terminalis of male rats after intermittent social defeat stress
Role of CRF receptor 1 antagonism in the bed nucleus of the stria terminalis of male rats after intermittent social defeat stress Open
We recently demonstrated that the experience of brief episodes of social defeat caused impairments in social behaviors. Moreover, we provided evidence that the antagonism of corticotropin-releasing factor binding protein (CRFBP) in the bed…
View article: Estresse por derrota social intermitente em ratos Wistar machos : revisão e modulação farmacológica experimental do sistema CRF
Estresse por derrota social intermitente em ratos Wistar machos : revisão e modulação farmacológica experimental do sistema CRF Open
O neuropeptídeo/hormônio CRF integra respostas de estresse a nível endócrino, imunológico e comportamental dos mamíferos. A atividade neuronal CRFérgica inapropriada pode estar por trás do aparecimento de sintomas associados a transtornos …
View article: Microglial Over-Activation by Social Defeat Stress Contributes to Anxiety- and Depressive-Like Behaviors
Microglial Over-Activation by Social Defeat Stress Contributes to Anxiety- and Depressive-Like Behaviors Open
Hyper activation of the neuroimmune system is strongly related to the development of neuropsychiatric disorders. Psychosocial stress has been postulated to play an important role in triggering anxiety and major depression. In preclinical m…
View article: Administration of a Histone Deacetylase Inhibitor into the Basolateral Amygdala Enhances Memory Consolidation, Delays Extinction, and Increases Hippocampal BDNF Levels
Administration of a Histone Deacetylase Inhibitor into the Basolateral Amygdala Enhances Memory Consolidation, Delays Extinction, and Increases Hippocampal BDNF Levels Open
Gene expression related to the formation and modification of memories is regulated epigenetically by chromatin remodeling through histone acetylation. Memory formation and extinction can be enhanced by treatment with inhibitors of histone …
View article: Social instigation and repeated aggressive confrontations in male Swiss mice: analysis of plasma corticosterone, CRF and BDNF levels in limbic brain areas
Social instigation and repeated aggressive confrontations in male Swiss mice: analysis of plasma corticosterone, CRF and BDNF levels in limbic brain areas Open
Introduction: Agonistic behaviors help to ensure survival, provide advantage in competition, and communicate social status. The resident-intruder paradigm, an animal model based on male intraspecific confrontations, can be an ethologically…
View article: Social instigation and repeated aggressive confrontations in male Swiss mice: analysis of plasma corticosterone, CRF and BDNF levels in limbic brain areas
Social instigation and repeated aggressive confrontations in male Swiss mice: analysis of plasma corticosterone, CRF and BDNF levels in limbic brain areas Open
Introduction: Agonistic behaviors help to ensure survival, provide advantage in competition, and communicate social status. The resident-intruder paradigm, an animal model based on male intraspecific confrontations, can be an ethologically…
View article: It is pleasant and heavy: convergence of visual contents in tobacco, alcohol and food marketing in Brazil
It is pleasant and heavy: convergence of visual contents in tobacco, alcohol and food marketing in Brazil Open
The tactical use of visuoperceptual content in marketing may encourage impulsive consumption of unhealthy products. In this study, the application of visuoperceptual content was compared in advertisements used by industries of tobacco, alc…
View article: Social defeat protocol and relevant biomarkers, implications for stress response physiology, drug abuse, mood disorders and individual stress vulnerability: a systematic review of the last decade
Social defeat protocol and relevant biomarkers, implications for stress response physiology, drug abuse, mood disorders and individual stress vulnerability: a systematic review of the last decade Open
Introduction: Social defeat (SD) in rats, which results from male intraspecific confrontations, is ethologically relevant and useful to understand stress effects on physiology and behavior.Methods: A systematic review of studies about biom…