Maisa Feghali
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View article: Fetal Polygenic Growth Score and Risk for Large for Gestational Age Birth Weight in Nulliparas: Secondary Analysis of a Prospective Cohort Study
Fetal Polygenic Growth Score and Risk for Large for Gestational Age Birth Weight in Nulliparas: Secondary Analysis of a Prospective Cohort Study Open
Background Large for gestational age birth weight is associated with both short- and long-term health consequences for offspring, and fetal genetics may contribute to risk for large for gestational age birth weight. Objectives We evaluated…
View article: Maternal and offspring genome-wide association study of C-reactive protein reveals limited polygenic association with gestational diabetes mellitus
Maternal and offspring genome-wide association study of C-reactive protein reveals limited polygenic association with gestational diabetes mellitus Open
Background C-reactive protein (CRP) is a well-established biomarker of systemic inflammation. In pregnancy, several studies show association of elevated CRP with gestational diabetes mellitus (GDM). However, the genetic contributions of CR…
View article: Periconceptional glycemic index and the risk of gestational diabetes mellitus and a large-for-gestational-age infant
Periconceptional glycemic index and the risk of gestational diabetes mellitus and a large-for-gestational-age infant Open
In a prospective cohort of nulliparous individuals with predominantly low GI in early pregnancy, the GI was not consistently associated with GDM or LGA birth. Further studies are needed to better understand the mechanisms by which diet-bas…
View article: From Standard of Care to Emerging Innovations: Navigating the Evolution of Pharmacological Treatment of Gestational Diabetes
From Standard of Care to Emerging Innovations: Navigating the Evolution of Pharmacological Treatment of Gestational Diabetes Open
The incidence of gestational diabetes mellitus (GDM) continues to increase in the United States and globally. While the first-line treatment of GDM remains diet and exercise, 30% of patients with GDM will require pharmacotherapy. However, …
View article: Comparative effectiveness trial of metformin versus insulin for the treatment of gestational diabetes in the USA: clinical trial protocol for the multicentre DECIDE study
Comparative effectiveness trial of metformin versus insulin for the treatment of gestational diabetes in the USA: clinical trial protocol for the multicentre DECIDE study Open
Introduction Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy. Glycaemic control decreases the risk of adverse pregnancy outcomes for the affected pregnant individual and the infant exposed i…
View article: Intensive glycaemic targets in overweight and obese individuals with gestational diabetes mellitus: clinical trial protocol for the iGDM study
Intensive glycaemic targets in overweight and obese individuals with gestational diabetes mellitus: clinical trial protocol for the iGDM study Open
Introduction The prevalence of both obesity and gestational diabetes mellitus (GDM) has increased, and each is associated with adverse perinatal outcomes including fetal overgrowth, neonatal morbidity, hypertensive disorders of pregnancy a…
View article: Study Design and Protocol of the Multisite Pregnancy 24/7 Cohort Study
Study Design and Protocol of the Multisite Pregnancy 24/7 Cohort Study Open
Hypertensive disorders of pregnancy and other adverse pregnancy outcomes (APOs) are associated with an increased risk of future maternal cardiovascular disease. Physical activity during pregnancy reduces the risk of these APOs, yet few mee…
View article: Mid-pregnancy sleep disturbances are not associated with mid-pregnancy maternal glycemia
Mid-pregnancy sleep disturbances are not associated with mid-pregnancy maternal glycemia Open
Background In pregnancy, epidemiological data have consistently shown strong associations between sleep quality and duration and maternal glycemia. However, other sleep disturbances such as difficulty falling asleep and staying asleep are …
View article: Treatment of Gestational Diabetes Mellitus and Offspring Early Childhood Growth
Treatment of Gestational Diabetes Mellitus and Offspring Early Childhood Growth Open
Background Gestational diabetes mellitus (GDM) is associated with fetal overgrowth, and certain treatments are associated with an increased risk of macrosomia. However, there are limited data about the long-term effect of GDM treatment on …
View article: Timing of Gestational Weight Gain and Adverse Perinatal Outcomes in Overweight and Obese Women
Timing of Gestational Weight Gain and Adverse Perinatal Outcomes in Overweight and Obese Women Open
OBJECTIVE: To evaluate whether inadequate or excessive gestational weight gain before the third trimester is associated with adverse pregnancy outcomes, and to evaluate the association of weight gain in the third trimester with fetal growt…