Maite Colinas
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View article: Discovery of iridoid cyclase completes the iridoid pathway in asterids
Discovery of iridoid cyclase completes the iridoid pathway in asterids Open
Iridoids are specialized monoterpenes ancestral to asterid flowering plants 1,2 that play key roles in defence and are also essential precursors for pharmacologically important alkaloids 3,4 . The biosynthesis of all iridoids involves the …
View article: Discovery of iridoid cyclase completes the iridoid pathway in asterids
Discovery of iridoid cyclase completes the iridoid pathway in asterids Open
Iridoids are specialized monoterpenes ancestral to asterid flowering plants (Albach et al , 2001; Stull et al , 2018). Iridoids play key roles in plant defense and are also essential precursors for pharmacologically important alkaloids (Do…
View article: Cell‐type‐aware regulatory landscapes governing monoterpene indole alkaloid biosynthesis in the medicinal plant <i>Catharanthus roseus</i>
Cell‐type‐aware regulatory landscapes governing monoterpene indole alkaloid biosynthesis in the medicinal plant <i>Catharanthus roseus</i> Open
Summary In plants, the biosynthetic pathways of some specialized metabolites are partitioned into specialized or rare cell types, as exemplified by the monoterpenoid indole alkaloid (MIA) pathway of Catharanthus roseus (Madagascar Periwink…
View article: Streamlined screening platforms lead to the discovery of pachysiphine synthase from <i>Tabernanthe iboga</i>
Streamlined screening platforms lead to the discovery of pachysiphine synthase from <i>Tabernanthe iboga</i> Open
Summary Plant‐specialized metabolism is largely driven by the oxidative tailoring of key chemical scaffolds catalyzed by cytochrome P450 (CYP450s) enzymes. Monoterpene indole alkaloids (MIAs) tabersonine and pseudo‐tabersonine, found in th…
View article: Streamlined screening platforms lead to the discovery of pachysiphine synthase from<i>Tabernanthe iboga</i>
Streamlined screening platforms lead to the discovery of pachysiphine synthase from<i>Tabernanthe iboga</i> Open
Summary Plant-specialized metabolism is largely driven by the oxidative tailoring of key chemical scaffolds catalyzed by cytochrome P450 (CYP450s) enzymes. The monoterpene indole alkaloids tabersonine and pseudo-tabersonine, found in the m…
View article: Cell-type aware regulatory landscapes governing monoterpene indole alkaloid biosynthesis in the medicinal plant<i>Catharanthus roseus</i>
Cell-type aware regulatory landscapes governing monoterpene indole alkaloid biosynthesis in the medicinal plant<i>Catharanthus roseus</i> Open
In plants, the biosynthetic pathways of some specialized metabolites are partitioned into specialized or rare cell types, as exemplified by the monoterpenoid indole alkaloid (MIA) pathway of Catharanthus roseus (Madagascar Periwinkle), the…
View article: PYRIDOX(AM)INE 5′-PHOSPHATE OXIDASE3 of<i>Arabidopsis thaliana</i>maintains carbon/nitrogen balance in distinct environmental conditions
PYRIDOX(AM)INE 5′-PHOSPHATE OXIDASE3 of<i>Arabidopsis thaliana</i>maintains carbon/nitrogen balance in distinct environmental conditions Open
The identification of factors that regulate C/N utilization in plants can make a substantial contribution to optimization of plant health. Here, we explored the contribution of pyridox(am)ine 5′-phosphate oxidase3 (PDX3), which regulates v…
View article: PDX3 is important for carbon/nitrogen balance in Arabidopsis associated with distinct environmental conditions
PDX3 is important for carbon/nitrogen balance in Arabidopsis associated with distinct environmental conditions Open
To survive and proliferate in diverse environments with varying climate and nutrient availability, plants modulate their metabolism. Achieving a balance between carbon (C) and nitrogen (N) use such that growth and defense mechanisms can be…
View article: Corrigendum: Interference between ER stress-related bZIP-type and jasmonate-inducible bHLH-type transcription factors in the regulation of triterpene saponin biosynthesis in Medicago truncatula
Corrigendum: Interference between ER stress-related bZIP-type and jasmonate-inducible bHLH-type transcription factors in the regulation of triterpene saponin biosynthesis in Medicago truncatula Open
[This corrects the article DOI: 10.3389/fpls.2022.903793.].
View article: The PRK/Rubisco shunt strongly influences Arabidopsis seed metabolism and oil accumulation, affecting more than carbon recycling
The PRK/Rubisco shunt strongly influences Arabidopsis seed metabolism and oil accumulation, affecting more than carbon recycling Open
The carbon efficiency of storage lipid biosynthesis from imported sucrose in green Brassicaceae seeds is proposed to be enhanced by the PRK/Rubisco shunt, in which ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco) acts outside the …
View article: Interference between ER stress-related bZIP-type and jasmonate-inducible bHLH-type transcription factors in the regulation of triterpene saponin biosynthesis in Medicago truncatula
Interference between ER stress-related bZIP-type and jasmonate-inducible bHLH-type transcription factors in the regulation of triterpene saponin biosynthesis in Medicago truncatula Open
Triterpene saponins (TS) are a structurally diverse group of metabolites that are widely distributed in plants. They primarily serve as defense compounds and their production is often triggered by biotic stresses through signaling cascades…
View article: Coenzymes and the primary and specialized metabolism interface
Coenzymes and the primary and specialized metabolism interface Open
In plants, primary and specialized metabolism have classically been distinguished as either essential for growth or required for survival in a particular environment. Coenzymes (organic cofactors) are essential for growth but their importa…
View article: Phosphorylated B6 vitamer deficiency in SALT OVERLY SENSITIVE 4 mutants compromises shoot and root development
Phosphorylated B6 vitamer deficiency in SALT OVERLY SENSITIVE 4 mutants compromises shoot and root development Open
Stunted growth in saline conditions is a signature phenotype of the Arabidopsis SALT OVERLY SENSITIVE mutants (sos1-5) affected in pathways regulating the salt stress response. One of the mutants isolated, sos4, encodes a kinase that phosp…
View article: Subfunctionalization of Paralog Transcription Factors Contributes to Regulation of Alkaloid Pathway Branch Choice in Catharanthus roseus
Subfunctionalization of Paralog Transcription Factors Contributes to Regulation of Alkaloid Pathway Branch Choice in Catharanthus roseus Open
Catharanthus roseus produces a diverse range of specialized metabolites of the monoterpenoid indole alkaloid (MIA) class in a heavily branched pathway. Recent great progress in identification of MIA biosynthesis genes revealed that the dif…
View article: Subfunctionalization of paralog transcription factors contributes to regulation of alkaloid pathway branch choice in<i>Catharanthus roseus</i>
Subfunctionalization of paralog transcription factors contributes to regulation of alkaloid pathway branch choice in<i>Catharanthus roseus</i> Open
SUMMARY Catharanthus roseus produces a diverse range of specialized metabolites of the monoterpenoid indole alkaloid (MIA) class in a heavily branched pathway. Recent great progress in identification of MIA biosynthesis genes revealed that…
View article: ER-Anchored Transcription Factors bZIP17 and bZIP60 Regulate Triterpene Saponin Biosynthesis in<i>Medicago truncatula</i><sup>1[OPEN]</sup>
ER-Anchored Transcription Factors bZIP17 and bZIP60 Regulate Triterpene Saponin Biosynthesis in<i>Medicago truncatula</i><sup>1[OPEN]</sup> Open
Triterpene saponins (TS) are a structurally diverse group of metabolites that are widely distributed in plants. They primarily serve as defense compounds and their production is often triggered by biotic stresses through signaling cascades…
View article: Mutant-Based Model of Two Independent Pathways for Carotenoid-Mediated Chloroplast Biogenesis in Arabidopsis Embryos
Mutant-Based Model of Two Independent Pathways for Carotenoid-Mediated Chloroplast Biogenesis in Arabidopsis Embryos Open
Chloroplasts are essential for autonomous plant growth, and their biogenesis is a complex process requiring both plastid and nuclear genome. One of the essential factors required for chloroplast biogenesis are carotenoids. Carotenoids are …
View article: Jasmonate and auxin perception: how plants keep F-boxes in check
Jasmonate and auxin perception: how plants keep F-boxes in check Open
Phytohormones regulate the plasticity of plant growth and development, and responses to biotic and abiotic stresses. Many hormone signal transduction cascades involve ubiquitination and subsequent degradation of proteins by the 26S proteas…
View article: Identification of Iridoid Glucoside Transporters in Catharanthus roseus
Identification of Iridoid Glucoside Transporters in Catharanthus roseus Open
Monoterpenoid indole alkaloids (MIAs) are plant defense compounds and high-value pharmaceuticals. Biosynthesis of the universal MIA precursor, secologanin, is organized between internal phloem-associated parenchyma (IPAP) and epidermis cel…
View article: Interaction between vitamin B<sub>6</sub>metabolism, nitrogen metabolism and autoimmunity
Interaction between vitamin B<sub>6</sub>metabolism, nitrogen metabolism and autoimmunity Open
The essential micronutrient vitamin B6 is best known in its enzymatic cofactor form, pyridoxal 5'-phosphate (PLP). However, vitamin B6 comprises the amine pyridoxamine 5'-phosphate (PMP) and the alcohol pyridoxine 5'-phosphate (PNP) in add…
View article: Balancing of B<sub>6</sub> Vitamers Is Essential for Plant Development and Metabolism in Arabidopsis
Balancing of B<sub>6</sub> Vitamers Is Essential for Plant Development and Metabolism in Arabidopsis Open
Vitamin B6 comprises a family of compounds that is essential for all organisms, most notable among which is the cofactor pyridoxal 5'-phosphate (PLP). Other forms of vitamin B6 include pyridoxamine 5'-phosphate (PMP), pyridoxine 5'-phospha…
View article: <i>Arabidopsis </i><scp>GERANYLGERANYL DIPHOSPHATE SYNTHASE</scp> 11 is a hub isozyme required for the production of most photosynthesis‐related isoprenoids
<i>Arabidopsis </i><span>GERANYLGERANYL DIPHOSPHATE SYNTHASE</span> 11 is a hub isozyme required for the production of most photosynthesis‐related isoprenoids Open
Summary Most plastid isoprenoids, including photosynthesis‐related metabolites such as carotenoids and the side chain of chlorophylls, tocopherols (vitamin E), phylloquinones (vitamin K), and plastoquinones, derive from geranylgeranyl diph…