Explanipedia

Exploring the natural history of bone mineral density in Duchenne muscular dystrophy: a systematic literature review Open

C. De Ford, Maitea Guridi, Yingjia Chen, Alexander P. Murphy, Claire Wood , et al. · 2025

Understanding the natural history of BMD and disease progression relating to bone fragility will help to support clinical trial design to assess and improve bone strength in DMD. To our knowledge, this is the first SLR investigating BMD Z-…

AAV gene therapy for Duchenne muscular dystrophy: the EMBARK phase 3 randomized trial Open

Jerry R. Mendell, Francesco Muntoni, Craig M. McDonald, Eugenio Mercuri, Emma Ciafaloni , et al. · 2024

O19: Integrated analyses of data from clinical trials of delandistrogene moxeparvovec gene therapy in DMD* Open

Erin O’Rourke, Crystal M. Proud, Craig M. Zaidman, Perry B. Shieh, Craig M. McDonald , et al. · 2023

The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia Open

Daniel J. Ham, Anastasiya Börsch, Shuo Lin, Marco Thürkauf, Martin R. Weihrauch , et al. · 2020

With human median lifespan extending into the 80s in many developed countries, the societal burden of age-related muscle loss (sarcopenia) is increasing. mTORC1 promotes skeletal muscle hypertrophy, but also drives organismal aging. Here, …

mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4 Open

Perrine Castets, Nathalie Rion, Marine Théodore, Denis Falcetta, Shuo Lin , et al. · 2019

Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism Open

Maitea Guridi, Barbara Kupr, Klaas Romanino, Shuo Lin, Denis Falcetta , et al. · 2016

Antioxidant peroxiredoxin 6 protein rescues toxicity due to oxidative stress and cellular hypoxia in vitro, and attenuates prion-related pathology in vivo Open

Ayodeji A. Asuni, Maitea Guridi, Sandrine Sanchez, Martin Sadowski · 2015

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