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View article: Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF
Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF Open
Stromal cells support epithelial cell and immune cell homeostasis and play an important role in inflammatory bowel disease (IBD) pathogenesis. Here, we quantify the stromal response to inflammation in pediatric IBD and reveal subset-specif…
View article: The single-cell transcriptional landscape of innate and adaptive lymphocytes in pediatric-onset colitis
The single-cell transcriptional landscape of innate and adaptive lymphocytes in pediatric-onset colitis Open
Innate lymphoid cells (ILCs) are considered innate counterparts of adaptive T cells; however, their common and unique transcriptional signatures in pediatric inflammatory bowel disease (pIBD) are largely unknown. Here, we report a dysregul…
View article: Frequent Occurrence of Perianal Disease and Granuloma Formation in Patients with Crohn’s Disease and Coexistent Orofacial Granulomatosis
Frequent Occurrence of Perianal Disease and Granuloma Formation in Patients with Crohn’s Disease and Coexistent Orofacial Granulomatosis Open
The results support the notion that CD in conjunction with OFG represents a specific phenotype of CD that is characterized by frequent perianal disease, pronounced intestinal granuloma formation and a need for extensive therapy.
View article: Patients with both Langerhans cell histiocytosis and Crohn’s disease highlight a common role of interleukin‐23
Patients with both Langerhans cell histiocytosis and Crohn’s disease highlight a common role of interleukin‐23 Open
Aim To present the first case series of patients with Langerhans cell histiocytosis (LCH) also affected by Crohn's disease (CD), both of which are granulomatous diseases, and in LCH investigate the role of interleukin (IL)‐23, which is a w…
View article: P054 Innate lymphoid cells in paediatric inflammatory bowel disease
P054 Innate lymphoid cells in paediatric inflammatory bowel disease Open
The incidence of paediatric IBD (PIBD) is on the rise. However, the underlying aetiology of PIBD remains largely unknown, indicating the dire need for more knowledge on the mechanisms driving this disease. Innate lymphoid cells (ILCs) cons…