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View article: Altered methylation of imprinted genes in neuroblastoma: implications for prognostic refinement
Altered methylation of imprinted genes in neuroblastoma: implications for prognostic refinement Open
Background Neuroblastoma (NB) is a complex disease, and the current understanding of NB biology is limited. Deregulation in genomic imprinting is a common event in malignancy. Since imprinted genes play crucial roles in early fetal growth …
View article: DNA methylation profiling improves routine diagnosis of paediatric central nervous system tumours: A prospective population‐based study
DNA methylation profiling improves routine diagnosis of paediatric central nervous system tumours: A prospective population‐based study Open
Aims Paediatric brain tumours are rare, and establishing a precise diagnosis can be challenging. Analysis of DNA methylation profiles has been shown to be a reliable method to classify central nervous system (CNS) tumours with high accurac…
View article: DNA methylation alterations across time and space in paediatric brain tumours
DNA methylation alterations across time and space in paediatric brain tumours Open
DNA methylation is increasingly used for tumour classification and has expanded upon the > 100 currently known brain tumour entities. A correct diagnosis is the basis for suitable treatment for patients with brain tumours, which is the lea…
View article: ETMR-10. Retrospective molecular re-evaluation of CNS PNETs; a population-based study
ETMR-10. Retrospective molecular re-evaluation of CNS PNETs; a population-based study Open
BACKGROUND: The heterogeneous group of tumors, primitive neuro-ectodermal tumors of the central nervous system (CNS-PNETs), is a group of rare childhood embryonal tumors associated with a poor prognosis. In recent years, molecular analyzes…
View article: PATH-08. DNA methylation profiling improves routine diagnostics of paediatric CNS tumours: a prospective population-based study
PATH-08. DNA methylation profiling improves routine diagnostics of paediatric CNS tumours: a prospective population-based study Open
AIMS: Paediatric brain tumours are rare and establishing a precise diagnosis can be challenging. Analysis of DNA methylation profiles has been shown to be a reliable method to classify central nervous system (CNS) tumours with high accurac…
View article: A SNP in the 5’ flanking region of the SAA1 gene is associated with serum levels of serum amyloid A and cardiovascular risk factors
A SNP in the 5’ flanking region of the SAA1 gene is associated with serum levels of serum amyloid A and cardiovascular risk factors Open
Background Elevated serum levels of serum amyloid A (SAA) are associated with increased risk of cardiovascular disease. In this study, we examine associations between allelic variation in the rs11024595 single nucleotide polymorphism (SNP)…