Majid Ebrahimi Warkiani
YOU?
Author Swipe
View article: Extracellular vesicles as a promising platform of precision medicine in liver cancer
Extracellular vesicles as a promising platform of precision medicine in liver cancer Open
Extracellular vesicles (EVs) are natural carriers of biological information and play pivotal roles in intercellular communication. EVs are biocompatible, have low immunogenicity, and are capable of traversing biological barriers, making th…
View article: Liquid Biopsy in Hepatocellular Carcinoma: ctDNA as a Potential Biomarker for Diagnosis and Prognosis
Liquid Biopsy in Hepatocellular Carcinoma: ctDNA as a Potential Biomarker for Diagnosis and Prognosis Open
View article: Prognostic Value of the Number of Circulating Tumor Cells in Patients with Metastatic Non-Small Cell Lung Cancer
Prognostic Value of the Number of Circulating Tumor Cells in Patients with Metastatic Non-Small Cell Lung Cancer Open
Investigating the molecular and genetic characteristics of circulating tumor cells (CTCs) presents a promising approach for personalizing treatment in patients with malignant neoplasms, given the limitations of traditional biopsy and histo…
View article: Revolutionizing biological digital twins: Integrating internet of bio-nano things, convolutional neural networks, and federated learning
Revolutionizing biological digital twins: Integrating internet of bio-nano things, convolutional neural networks, and federated learning Open
Digital twins (DTs) are advancing biotechnology by providing digital models for drug discovery, digital health applications, and biological assets, including microorganisms. However, the hypothesis posits that implementing micro- and nanos…
View article: The FKBPL-based therapeutic peptide, AD-01, protects the endothelium from hypoxia-induced damage by stabilising hypoxia inducible factor-α and inflammation
The FKBPL-based therapeutic peptide, AD-01, protects the endothelium from hypoxia-induced damage by stabilising hypoxia inducible factor-α and inflammation Open
Background Endothelial dysfunction is a hallmark feature of cardiovascular disease (CVD), yet the underlying mechanisms are still poorly understood. This has impeded the development of effective therapies, particularly for peripheral arter…
View article: Spatial interaction mapping of PD-1/PD-L1 in head and neck cancer reveals the role of macrophage-tumour barriers associated with immunotherapy response
Spatial interaction mapping of PD-1/PD-L1 in head and neck cancer reveals the role of macrophage-tumour barriers associated with immunotherapy response Open
Background Mucosal head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage, where the prognosis is poor due to the high rates of recurrence and metastasis. With approximately one million new cases projected in…
View article: A COVID‐19 rapid antigen test employing upconversion nanoparticles
A COVID‐19 rapid antigen test employing upconversion nanoparticles Open
The COVID‐19 pandemic has underscored the critical need for rapid and accurate diagnostic tools. Current methods, including Polymerase Chain Reaction and rapid antigen tests (RAT), have limitations in speed, sensitivity, and the requiremen…
View article: Decoding sEV-Mediated Metastasis in Organoid-on-a-Chip Models: Advancing from Static to Dynamic Imaging
Decoding sEV-Mediated Metastasis in Organoid-on-a-Chip Models: Advancing from Static to Dynamic Imaging Open
View article: Spatial interaction mapping of PD-1/PD-L1 in Head and Neck Cancer reveals the role of Macrophage-Tumour Barriers associated with immunotherapy response
Spatial interaction mapping of PD-1/PD-L1 in Head and Neck Cancer reveals the role of Macrophage-Tumour Barriers associated with immunotherapy response Open
Background Mucosal head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage, where the prognosis is poor due to the high rates of recurrence and metastasis [1]. With approximately one million new cases projecte…
View article: Spatial interaction mapping of PD-1/PD-L1 in Head and Neck Cancer reveals the role of Macrophage-Tumour Barriers associated with immunotherapy response
Spatial interaction mapping of PD-1/PD-L1 in Head and Neck Cancer reveals the role of Macrophage-Tumour Barriers associated with immunotherapy response Open
Background Mucosal head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage, where the prognosis is poor due to the high rates of recurrence and metastasis [1]. With approximately one million new cases projecte…
View article: A biomimetic sperm selection device for routine sperm selection
A biomimetic sperm selection device for routine sperm selection Open
Channel-based biomimetic sperm selection can passively select motile sperm with low DNA fragmentation. When compared with DGC, this method isolates fewer sperm but with a higher proportion of progressively motile cells and greater DNA inte…
View article: A COVID-19 Rapid Antigen Test Employing Upconversion Nanoparticles
A COVID-19 Rapid Antigen Test Employing Upconversion Nanoparticles Open
The COVID-19 pandemic has underscored the critical need for rapid and accurate diagnostic tools. Current methods, including PCR and rapid antigen tests (RAT), have limitations in speed, sensitivity, and the requirement for specialized equi…
View article: Spatial dynamics of tertiary lymphoid aggregates in head and neck cancer: insights into immunotherapy response
Spatial dynamics of tertiary lymphoid aggregates in head and neck cancer: insights into immunotherapy response Open
Background Recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) generally has a poor prognosis for patients with limited treatment options. While incorporating immune checkpoint inhibitors (ICIs) has now become the standa…
View article: The FKBPL-based therapeutic peptide, AD-01, protects the endothelium from hypoxia-induced damage by stabilizing hypoxia inducible factor-α and inflammation
The FKBPL-based therapeutic peptide, AD-01, protects the endothelium from hypoxia-induced damage by stabilizing hypoxia inducible factor-α and inflammation Open
Aims: FK506-binding protein like (FKBPL) and its therapeutic peptide mimetic, AD-01, are crucial negative regulators of angiogenesis, yet the underlying mechanisms involved in hypoxia- and/or inflammation-induced cardiovascular disease (CV…
View article: Small Extracellular Vesicle-Derived Circular RNA hsa_circ_0007386 as a Biomarker for the Diagnosis of Pleural Mesothelioma
Small Extracellular Vesicle-Derived Circular RNA hsa_circ_0007386 as a Biomarker for the Diagnosis of Pleural Mesothelioma Open
Pleural mesothelioma (PM) is a highly aggressive tumor that is caused by asbestos exposure and lacks effective therapeutic regimens. Current procedures for PM diagnosis are invasive and can take a long time to reach a definitive result. Sm…
View article: Circulating tumour cells predict recurrences and survival in head and neck squamous cell carcinoma patients
Circulating tumour cells predict recurrences and survival in head and neck squamous cell carcinoma patients Open
View article: Enrichment of T-lymphocytes from leukemic blood using inertial microfluidics toward improved chimeric antigen receptor-T cell manufacturing
Enrichment of T-lymphocytes from leukemic blood using inertial microfluidics toward improved chimeric antigen receptor-T cell manufacturing Open
Chimeric antigen receptor (CAR-T) cell therapy is a successful immunotherapy for treatment of blood cancers. However, hurdles in their manufacturing remain including efficient isolation and purification of the T-cell starting material. Her…
View article: Advancements in Aptamer‐Driven DNA Nanostructures for Precision Drug Delivery
Advancements in Aptamer‐Driven DNA Nanostructures for Precision Drug Delivery Open
DNA nanostructures exhibit versatile geometries and possess sophisticated capabilities not found in other nanomaterials. They serve as customizable nanoplatforms for orchestrating the spatial arrangement of molecular components, such as bi…
View article: Small extracellular vesicle-derived circular RNA hsa_circ_0007386 as a biomarker for the diagnosis of Pleural Mesothelioma
Small extracellular vesicle-derived circular RNA hsa_circ_0007386 as a biomarker for the diagnosis of Pleural Mesothelioma Open
Pleural mesothelioma (PM) is a highly aggressive tumor that is caused by asbestos exposure and lacks effective therapeutic regimens. Current procedures for PM diagnosis are invasive and can take a long time to reach a definitive result. Sm…
View article: Poor patient outcome correlates with active engulfment of cytokeratin positive CTCs within cancer-associated monocyte population in lung cancer
Poor patient outcome correlates with active engulfment of cytokeratin positive CTCs within cancer-associated monocyte population in lung cancer Open
View article: Evaluation of an artificial intelligence-facilitated sperm detection tool in azoospermic samples for use in ICSI
Evaluation of an artificial intelligence-facilitated sperm detection tool in azoospermic samples for use in ICSI Open
Can artificial intelligence (AI) improve the efficiency and efficacy of sperm searches in azoospermic samples? This two-phase proof-of-concept study began with a training phase using eight azoospermic patients (>10,000 sperm images) to pro…
View article: In situ characterization of the tumor microenvironment
In situ characterization of the tumor microenvironment Open
The development of new therapies for cancer is underpinned by an increasing need to comprehensively characterize the tumor microenvironment (TME). While traditional approaches have relied on bulk or single-cell approaches, these are limite…
View article: Spatial proteomic profiling of tumor and stromal compartments in non‐small‐cell lung cancer identifies signatures associated with overall survival
Spatial proteomic profiling of tumor and stromal compartments in non‐small‐cell lung cancer identifies signatures associated with overall survival Open
Objectives Non‐small‐cell lung carcinoma (NSCLC) is the most prevalent and lethal form of lung cancer. The need for biomarker‐informed stratification of targeted therapies has underpinned the need to uncover the underlying properties of th…
View article: Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signatures
Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signatures Open
Objectives Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) virus infection in pregnancy is associated with higher incidence of placental dysfunction, referred to by a few studies as a ‘preeclampsia‐like syndrome’. However, the…
View article: Characterisation of circulating tumor‐associated and immune cells in patients with advanced‐stage non‐small cell lung cancer
Characterisation of circulating tumor‐associated and immune cells in patients with advanced‐stage non‐small cell lung cancer Open
Objectives Globally, non‐small cell lung cancer (NSCLC) is the most prevalent form of lung cancer and the leading cause of cancer‐related deaths. Tumor‐associated circulating cells in NSCLC can have a wide variety of morphological and phen…
View article: Nanomaterial-assisted wearable glucose biosensors for noninvasive real-time monitoring: Pioneering point-of-care and beyond
Nanomaterial-assisted wearable glucose biosensors for noninvasive real-time monitoring: Pioneering point-of-care and beyond Open
This review explores glucose monitoring and management strategies, emphasizing the need for reliable and user-friendly wearable sensors that are the next generation of sensors for continuous glucose detection. In addition, examines key str…
View article: A hybridized mechano-electroporation technique for efficient immune cell engineering
A hybridized mechano-electroporation technique for efficient immune cell engineering Open
View article: AI facilitated sperm detection in azoospermic samples for use in ICSI
AI facilitated sperm detection in azoospermic samples for use in ICSI Open
Research question Can artificial intelligence (AI) improve efficiency and efficacy of sperm searches in azoospermic samples? Design This two-phase proof-of-concept study beginning with a training phase using 8 azoospermic patients (>10000 …
View article: Zerumbone liquid crystalline nanoparticles protect against oxidative stress, inflammation and senescence induced by cigarette smoke extract in vitro
Zerumbone liquid crystalline nanoparticles protect against oxidative stress, inflammation and senescence induced by cigarette smoke extract in vitro Open
View article: <i>Green Biomaterials</i> : fundamental principles
<i>Green Biomaterials</i> : fundamental principles Open
Non peer reviewed