Maha Othman
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View article: Proton beam therapy indications in the Kingdom of Saudi Arabia
Proton beam therapy indications in the Kingdom of Saudi Arabia Open
The Panel did not recommend the routine use of proton therapy for all cancers. Each case should be assessed individually following a multidisciplinary review and expert consultation while accounting for financial, logistical, and patient-s…
View article: Clinicopathological insights and management of liver metastases: Current advances and future perspectives
Clinicopathological insights and management of liver metastases: Current advances and future perspectives Open
Liver metastases are a leading contributor to cancer-related illness and death, occurring far more frequently than primary liver tumors. Their management remains highly challenging due to the complexity of disease behavior and the need for…
View article: Developing an AI-Generated Peptide Targeting Platelet-type von Willebrand Disease
Developing an AI-Generated Peptide Targeting Platelet-type von Willebrand Disease Open
Platelet-type von Willebrand disease (PT-VWD) is a rare bleeding disorder caused by gain-of-function mutations in platelet glycoprotein Ib alpha (GPIbα). These mutations lead to a hyperactive protein-protein interaction (PPI) with von Will…
View article: Coagulation markers as independent predictors of colorectal cancer aggressiveness
Coagulation markers as independent predictors of colorectal cancer aggressiveness Open
Background Colorectal cancer (CRC) is frequently associated with thrombosis with thrombotic events, such as deep vein thrombosis or pulmonary embolism, often correlate with poor clinical outcomes. Coagulation markers have been suggested as…
View article: Optimal Cutoff for the Neutrophil-to-Lymphocyte Ratio as a Tool for Pre-chemotherapy Prognosis Stratification of Breast Cancer Patients
Optimal Cutoff for the Neutrophil-to-Lymphocyte Ratio as a Tool for Pre-chemotherapy Prognosis Stratification of Breast Cancer Patients Open
Introduction The neutrophil-to-lymphocyte ratio (NLR) is an established inflammatory marker in cancer patients. The optimal cut-off as an independent prognostic factor for breast cancer (BC) progression in patients undergoing chemotherapy …
View article: Deciphering prognostic markers in gastric signet ring cell carcinoma: Human epidermal growth factor receptor 2 and other key factors
Deciphering prognostic markers in gastric signet ring cell carcinoma: Human epidermal growth factor receptor 2 and other key factors Open
BACKGROUND Gastric signet ring cell carcinoma (SRCC) is a rare, aggressive subtype of gastric cancer characterized by poor prognosis and distinctive biological behavior. Despite advances in gastric cancer treatment, SRCC remains difficult …
View article: Diagnostic insights into solid pseudopapillary neoplasms of the pancreas: a decade of experience with pediatric representation
Diagnostic insights into solid pseudopapillary neoplasms of the pancreas: a decade of experience with pediatric representation Open
Background Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare, low-grade malignancies that predominantly affect young females. Their diagnosis is often facilitated by a characteristic histomorphological pattern and immunohisto…
View article: Adherence to Parenteral Methotrexate Compared to Oral Route in Patients with Rheumatoid Arthritis
Adherence to Parenteral Methotrexate Compared to Oral Route in Patients with Rheumatoid Arthritis Open
Background and objectives: Rheumatoid arthritis is a chronic autoimmune inflammatory disease, which causes discomfort, swelling, stiffness, and eventual joint destruction. Methotrexate is a Disease Modifying Anti-Rheumatic Drug with a spec…
View article: Optimal Cutoff for Neutrophil-to-Lymphocyte Ratio as a Tool for Pre-Chemotherapy Prognosis Stratification of Breast Cancer Patients
Optimal Cutoff for Neutrophil-to-Lymphocyte Ratio as a Tool for Pre-Chemotherapy Prognosis Stratification of Breast Cancer Patients Open
Introduction: The neutrophil-to-lymphocyte ratio (NLR) is an established inflammatory marker in cancerpatients. The optimal cut-off as an independent prognostic factor for breast cancer (BC) progression in patients undergoing chemotherapy …
View article: Thromboelastometry (<scp>ROTEM</scp>) Assessing Hypercoagulability in Patients Referred for Thrombophilia Screening
Thromboelastometry (<span>ROTEM</span>) Assessing Hypercoagulability in Patients Referred for Thrombophilia Screening Open
Introduction Thrombophilia, a blood coagulation disorder, poses risks of venous thromboembolism (VTE). Coagulation assays may not be sufficient to assess VTE risk and global assays such as Rotational Thromboelastometry (ROTEM) may add valu…
View article: Red Cell Distribution Width and the Early Detection of Ovarian Cancer
Red Cell Distribution Width and the Early Detection of Ovarian Cancer Open
Ovarian Cancer is a leading cause of mortality and morbidity, lacking clinical manifestations and effective early diagnostic techniques. The majority of cases are diagnosed at later stages; however, asymptomatic screening is currently not …
View article: Characterizing coagulation responses in humans and nonhuman primates following kidney xenotransplantation—A narrative review
Characterizing coagulation responses in humans and nonhuman primates following kidney xenotransplantation—A narrative review Open
The recent report of the first pig kidney transplant in a living human brings hope to thousands of people with end‐stage kidney failure. The scientific community views this early success with caution as kidney xenotransplantation exhibits …
View article: Management of Venous and Arterial Thrombosis
Management of Venous and Arterial Thrombosis Open
A thrombus is a hemostatic plug localized in a blood vessel [...]
View article: Assessing hypercoagulability and <scp>VTE</scp> risk using thromboelastography and Khorana score in women with cancers receiving chemotherapy
Assessing hypercoagulability and <span>VTE</span> risk using thromboelastography and Khorana score in women with cancers receiving chemotherapy Open
Venous thromboembolism (VTE) is a common occurrence in cancer and chemotherapy increases thrombosis risk. Current risk assessment models such as the Khorana score (KS) and its modifications have limitations in female cancers. We assessed t…
View article: Incidence and risk factors of venous and arterial thromboembolic events among patients with ovarian cancer- data from a large Canadian database
Incidence and risk factors of venous and arterial thromboembolic events among patients with ovarian cancer- data from a large Canadian database Open
Risk factors predictive of thrombosis in ovarian cancer patients are not consistent between ATE and VTE, thus thrombotic events should not be combined for analysis. Differential thrombosis risk assessment is needed to improve prevention st…
View article: Hematologic characteristics and coagulopathy in pregnancy with COVID-19 succeeding the first wave: a multicenter retrospective cross-sectional study
Hematologic characteristics and coagulopathy in pregnancy with COVID-19 succeeding the first wave: a multicenter retrospective cross-sectional study Open
Our findings add valuable insights into the nature of hematologic test characteristics, bleeding, and thrombotic complications for those affected with COVID-19 in pregnancy, reassuring readers of the low incidence of bleeding and thromboti…
View article: Report of the ISTH registry on pregnancy and COVID-19-associated coagulopathy (COV-PREG-COAG)
Report of the ISTH registry on pregnancy and COVID-19-associated coagulopathy (COV-PREG-COAG) Open
Background Concerns about COVID-19-associated coagulopathy (CAC) in pregnant individuals were raised in early pandemic. Methods An ISTH-sponsored COVID-19 coagulopathy in pregnancy (COV-PREG-COAG) international registry was developed to de…
View article: PB0744 Examining the Effect of Chemotherapy on Platelet Count and Function in Women with Cancer
PB0744 Examining the Effect of Chemotherapy on Platelet Count and Function in Women with Cancer Open
treatment response particularly in older patients.
View article: PB0993 Thromboelastometry (ROTEM) in Detection of Hypercoagulability in Patients Referred for Thrombophilia Screening
PB0993 Thromboelastometry (ROTEM) in Detection of Hypercoagulability in Patients Referred for Thrombophilia Screening Open
Comparison of TG parameters in NDMM patients at baseline, after cycle 1 and after cycle 4.Data represent mean ± standard deviation.P values less than 0.05 were considered statistically significant.
View article: Effect of diode laser irradiation in combination with different re-mineralizing agents on enamel micro-hardness (in-vitro study)
Effect of diode laser irradiation in combination with different re-mineralizing agents on enamel micro-hardness (in-vitro study) Open
Objective: This study was carried to evaluate the influence of Fluor protectors (1.5% amonium fluoride varnish) and white varnish (5% sodium fluoride varnish) after irradiation with diode laser on enamel micro-hardness. Materials and metho…
View article: Comparison of 2 ways of performing ristocetin-induced platelet agglutination mixing study for diagnosis of type 2B von Willebrand disease. Response to the publication of Soleimani et al
Comparison of 2 ways of performing ristocetin-induced platelet agglutination mixing study for diagnosis of type 2B von Willebrand disease. Response to the publication of Soleimani et al Open
We are thankful for the opportunity to respond to the recent letter from Soleimani et al. [[1]Soleimani R, Khourssaji M, Cabo J, Guldenpfennig M, Baudar J, Chatelain B, et al. Comparison of two ways of performing ristocetin-induced platele…
View article: Uncoupling Protein 2 and Dynamin-related Protein 1mRNA Expression as Genetic Markers for Vitiligo
Uncoupling Protein 2 and Dynamin-related Protein 1mRNA Expression as Genetic Markers for Vitiligo Open
Background: Vitiligo is a depigmenting skin condition characterized by specific melanocyte depletion, resulting in the attenuation of melanin within the affected skin regions.Mitochondrial dysfunction and oxidative stress have been implica…