Makhotso Lekhooa
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View article: Phytochemistry, Antibacterial and Antioxidant Activities of <i>Grewia lasiocarpa</i> E. Mey. Ex Harv. Fungal Endophytes: A Computational and Experimental Validation Study
Phytochemistry, Antibacterial and Antioxidant Activities of <i>Grewia lasiocarpa</i> E. Mey. Ex Harv. Fungal Endophytes: A Computational and Experimental Validation Study Open
The genus Grewia are well‐known for their medicinal properties and are widely used in traditional remedies due to their rich phytochemical composition and potential health benefits. This study isolated and characterized five endophytic fun…
View article: Phytochemical Profiles, Micromorphology, and Elemental Composition of Gomphocarpus fruticosus (L.) W.T. Aiton and Leonotis leonurus (L.) R.Br., Plants Used for Managing Antidepressant-like Conditions in Folk Medicine
Phytochemical Profiles, Micromorphology, and Elemental Composition of Gomphocarpus fruticosus (L.) W.T. Aiton and Leonotis leonurus (L.) R.Br., Plants Used for Managing Antidepressant-like Conditions in Folk Medicine Open
Medicinal plants have been used to treat mental health-related conditions among different ethic groups. Among the commonly used plants in South Africa are Gomphocarpus fruticosus (L.) W.T.Aiton and Leonotis leonurus (L.) R.Br. This study a…
View article: South African medicinal plants used for health conditions affecting males: an ethnobotanical review
South African medicinal plants used for health conditions affecting males: an ethnobotanical review Open
Health issues affecting males remain a public health challenge due to the limited treatments and male health-seeking behaviour. In South Africa, local communities have relied on plant-based therapies to address health issues including thos…
View article: Chemical composition and antifertility effect of a South African herbal mixture in female Sprague-Dawley rats
Chemical composition and antifertility effect of a South African herbal mixture in female Sprague-Dawley rats Open
Herbal contraceptives are often considered as an affordable and accessible option for birth control practice. This study evaluated the antifertility activity of a South African herbal mixture made from three plants (Helichrysum caespititiu…
View article: Utilisation of medicinal plants for their antifertility activities: A bibliometric analysis of research endeavours from 1968 to 2023
Utilisation of medicinal plants for their antifertility activities: A bibliometric analysis of research endeavours from 1968 to 2023 Open
Background: The exponential expansion of the population, in conjunction with the escalating negative side effects associated with synthetic contraceptives, has prompted the exploration of alternative fertility control agents, particularly …
View article: Preliminary Screening of South African Plants for Binding Affinity to the Serotonin Reuptake Transporter and Adenosine A1/A2A Receptors
Preliminary Screening of South African Plants for Binding Affinity to the Serotonin Reuptake Transporter and Adenosine A1/A2A Receptors Open
In South African traditional medicine, Gomphocarpus fruticosus (L.) W.T. Aiton, Hypoxis hemerocallidea Fisch. & C.A. Mey., and Leonotis leonurus. (L.) R.Br. have been recorded among different ethnic groups to be a valuable herbal remedy fo…
View article: Antidepressant effects of coumarins and their derivatives: A critical analysis of research advances
Antidepressant effects of coumarins and their derivatives: A critical analysis of research advances Open
Coumarins and their derivatives are non-flavonoids polyphenols with diverse pharmacological activities including anti-depressant effects. This study systematically examines the antidepressant effects of coumarins and their derivatives in r…
View article: Development and Biomechanics of Grewia lasiocarpa E. Mey. Ex Harv. Trichomes Exudate
Development and Biomechanics of Grewia lasiocarpa E. Mey. Ex Harv. Trichomes Exudate Open
Grewia lasiocarpa E. Mey. Ex Harv., Malvaceae (forest raisin) is a tropical small tree or shrub valued for its ecological importance as well as its nutritional, antioxidant, antibacterial, and anti-cancer properties as well as its ecologic…
View article: Endophytic Effect of the South African Beauveria bassiana Strain PPRI 7598 on the Population Growth and Development of the Russian Wheat Aphid, Diuraphis noxia
Endophytic Effect of the South African Beauveria bassiana Strain PPRI 7598 on the Population Growth and Development of the Russian Wheat Aphid, Diuraphis noxia Open
The Russian wheat aphid (RWA), Diuraphis noxia (Kurdjumov), is one of the main pests of small-grain cereal crops, including bread wheat, Triticum aestivum (Poaceae). In a series of glasshouse experiments, we evaluated the systemic effect o…
View article: Antidepressant Effects of South African Plants: An Appraisal of Ethnobotanical Surveys, Ethnopharmacological and Phytochemical Studies
Antidepressant Effects of South African Plants: An Appraisal of Ethnobotanical Surveys, Ethnopharmacological and Phytochemical Studies Open
Globally, the search for safe and potent natural-based treatment for depression is receiving renewed interest given the numerous side-effects associated with many existing drugs. In South Africa, the use of plants to manage depression and …
View article: Reduction in basal plasma Adrenocorticotropic hormone (ACTH) and Prolactin during treatment with escitalopram for depression
Reduction in basal plasma Adrenocorticotropic hormone (ACTH) and Prolactin during treatment with escitalopram for depression Open
Reduction in basal plasma Adrenocorticotropic hormone (ACTH) and prolactin during treatment with escitalopram for depression.
View article: African molecular diversity for library design and discovery
African molecular diversity for library design and discovery Open
Background: Recent efforts in the discovery of novel drug-like molecules through conventional synthetic chemical and virtual libraries and computational screenings have made only marginal progress to present novel therapeutic modalities to…
View article: A case study of Phela an African herbal medicine on evidence based research
A case study of Phela an African herbal medicine on evidence based research Open
BACKGROUND: Phela is an African herbal medicine derived from four South-African plants. For generations, combination of these plants has been used successfully to alleviate symptoms in patients with a wasting syndrome, commonly seen in HIV…