Maki Ikeura
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View article: AB012. Tissue uptake of novel boron neutron capture therapy compounds in a mouse model, with pharmacokinetic and dosimetric extrapolation to human treatment
AB012. Tissue uptake of novel boron neutron capture therapy compounds in a mouse model, with pharmacokinetic and dosimetric extrapolation to human treatment Open
View article: First Estimation of the Clinical Utility of Boronotyrosine as a Boron Delivery Compound for Boron Neutron Capture Therapy in Head and Neck Cancer
First Estimation of the Clinical Utility of Boronotyrosine as a Boron Delivery Compound for Boron Neutron Capture Therapy in Head and Neck Cancer Open
View article: First estimation of the clinical utility of boronotyrosine as a boron delivery compound for boron neutron capture therapy in head and neck cancer
First estimation of the clinical utility of boronotyrosine as a boron delivery compound for boron neutron capture therapy in head and neck cancer Open
View article: Supplementary Figures 1 - 2 from STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment
Supplementary Figures 1 - 2 from STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment Open
Supplementary Figure 1. Induction profiles of various known DNA sensors and adaptors in the glioma microenvoironment. Supplementary Figure 2. STING agonist promotes type-I IFN signaling in BILs.
View article: Data from STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment
Data from STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment Open
Although type I IFNs play critical roles in antiviral and antitumor activity, it remains to be elucidated how type I IFNs are produced in sterile conditions of the tumor microenvironment and directly affect tumor-infiltrating immune cells.…
View article: Data from STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment
Data from STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment Open
Although type I IFNs play critical roles in antiviral and antitumor activity, it remains to be elucidated how type I IFNs are produced in sterile conditions of the tumor microenvironment and directly affect tumor-infiltrating immune cells.…
View article: Supplementary Figures 1 - 2 from STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment
Supplementary Figures 1 - 2 from STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment Open
Supplementary Figure 1. Induction profiles of various known DNA sensors and adaptors in the glioma microenvoironment. Supplementary Figure 2. STING agonist promotes type-I IFN signaling in BILs.
View article: Supplementary Figure 2 from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma
Supplementary Figure 2 from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma Open
PDF file - 439K, Additional representative images of HLA Class I and CD8 immunohistochemistry.
View article: Supplementary Figure 1 from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma
Supplementary Figure 1 from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma Open
PDF file - 75K, Microsatellite markers on chromosome 6.
View article: Data from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma
Data from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma Open
Purpose: Glioblastoma (GBM) shows downregulated expression of human leukocyte antigen (HLA) class I, thereby escaping from cytotoxic T cells and limiting the efficacy of immunotherapy. Loss of heterozygosity (LOH) of HLA class I (6p…
View article: Supplementary Table 2 from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma
Supplementary Table 2 from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma Open
PDF file - 96K, Summary of specificity of anti-HLA Class I antibodies.
View article: Supplementary Table 2 from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma
Supplementary Table 2 from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma Open
PDF file - 96K, Summary of specificity of anti-HLA Class I antibodies.
View article: Supplementary Table 1 from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma
Supplementary Table 1 from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma Open
PDF file - 67K, Characteristics of patients who underwent standard of care.
View article: Supplementary Figure Legend from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma
Supplementary Figure Legend from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma Open
PDF file - 65K
View article: Supplementary Table 1 from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma
Supplementary Table 1 from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma Open
PDF file - 67K, Characteristics of patients who underwent standard of care.
View article: Supplementary Figure 1 from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma
Supplementary Figure 1 from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma Open
PDF file - 75K, Microsatellite markers on chromosome 6.
View article: Supplementary Figure Legend from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma
Supplementary Figure Legend from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma Open
PDF file - 65K
View article: Data from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma
Data from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma Open
Purpose: Glioblastoma (GBM) shows downregulated expression of human leukocyte antigen (HLA) class I, thereby escaping from cytotoxic T cells and limiting the efficacy of immunotherapy. Loss of heterozygosity (LOH) of HLA class I (6p…
View article: Supplementary Figure 2 from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma
Supplementary Figure 2 from LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma Open
PDF file - 439K, Additional representative images of HLA Class I and CD8 immunohistochemistry.
View article: IFN-γ- and IL-17-producing CD8<sup>+</sup> T (Tc17-1) cells in combination with poly-ICLC and peptide vaccine exhibit antiglioma activity
IFN-γ- and IL-17-producing CD8<sup>+</sup> T (Tc17-1) cells in combination with poly-ICLC and peptide vaccine exhibit antiglioma activity Open
Background While adoptive transfer of T-cells has been a major medical breakthrough for patients with B cell malignancies, the development of safe and effective T-cell-based immunotherapy for central nervous system (CNS) tumors, such as gl…
View article: Histamine deficiency promotes accumulation of immunosuppressive immature myeloid cells and growth of murine gliomas
Histamine deficiency promotes accumulation of immunosuppressive immature myeloid cells and growth of murine gliomas Open
To elucidate mechanisms underlying epidemiological findings of decreased risk of glioma development in patients with allergies and asthma, gliomas were induced in mice deficient for histidine decarboxylase (HDC), the enzyme responsible for…
View article: Transgene-derived overexpression of miR-17-92 in CD8+ T-cells confers enhanced cytotoxic activity
Transgene-derived overexpression of miR-17-92 in CD8+ T-cells confers enhanced cytotoxic activity Open