Makoto Tominaga
YOU?
Author Swipe
View article: Monoacylglycerol acyltransferase maintains ionotropic receptor expression for cool temperature sensing and avoidance in Drosophila
Monoacylglycerol acyltransferase maintains ionotropic receptor expression for cool temperature sensing and avoidance in Drosophila Open
View article: Alternative Splicing in TRPA1 Drives Sensory Adaptation to Electrophiles in Drosophilids
Alternative Splicing in TRPA1 Drives Sensory Adaptation to Electrophiles in Drosophilids Open
Behaviors are among the first traits to evolve as animals enter new niches, but their molecular bases are poorly understood. To address this gap, we used the mustard-feeding drosophilid fly Scaptomyza flava , which feeds on toxic Brassical…
View article: Editorial: Special issue on thermosensitive TRP channels
Editorial: Special issue on thermosensitive TRP channels Open
View article: TRPA1 and thermosensitivity
TRPA1 and thermosensitivity Open
TRPA1 was first identified as a noxious cold receptor in mice in 2003. Multiple TRPA1 genes have since been isolated, indicating that TRPA1 emerged early in evolution and showing the existence of TRPA1 variants in a range of species, inclu…
View article: TRPV3 in skin thermosensation and temperature responses
TRPV3 in skin thermosensation and temperature responses Open
View article: TRPV1 and thermosensitivity
TRPV1 and thermosensitivity Open
View article: Aluminum potassium sulfate inhibits TRPV1 and TRPA1 activation
Aluminum potassium sulfate inhibits TRPV1 and TRPA1 activation Open
View article: Functional characterization of thermosensitive TRPV channels from holocephalan elephant shark (<i>Callorhinchus milii</i>) illuminate the ancestral thermosensory system in vertebrates
Functional characterization of thermosensitive TRPV channels from holocephalan elephant shark (<i>Callorhinchus milii</i>) illuminate the ancestral thermosensory system in vertebrates Open
Homeostasis and survival of various animal species have been affected by changes in environmental temperature, causing animals to evolve physiological systems for sensing ambient and body temperature. Temperature-sensitive transient recept…
View article: Retraction for Hiramatsu et al., “The Mechanism of Pertussis Cough Revealed by the Mouse-Coughing Model”
Retraction for Hiramatsu et al., “The Mechanism of Pertussis Cough Revealed by the Mouse-Coughing Model” Open
View article: Propofol reduces human TRPA1 activity in a warm environment
Propofol reduces human TRPA1 activity in a warm environment Open
View article: TRPV1-Expressing Neurons in the Dorsal Raphe Nucleus are Activated by Self or Others’ Pain
TRPV1-Expressing Neurons in the Dorsal Raphe Nucleus are Activated by Self or Others’ Pain Open
View article: Transient receptor potential vanilloid 4 gene-deficiency attenuates the inhibitory effect of 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid on vascular permeability in mice
Transient receptor potential vanilloid 4 gene-deficiency attenuates the inhibitory effect of 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid on vascular permeability in mice Open
We investigated whether an anti-inflammatory lipid metabolite named 5,6-DiHETE reduces vascular permeability by inhibiting TRPV4 channels in vivo. In wild-type (WT) mice, histamine-induced dye extravasation was reduced by pre-administratio…
View article: Structural basis of TRPV1 inhibition by SAF312 and cholesterol
Structural basis of TRPV1 inhibition by SAF312 and cholesterol Open
View article: Monoacylglycerol acyltransferase maintains ionotropic receptor expression for cool temperature sensing and avoidance in<i>Drosophila</i>
Monoacylglycerol acyltransferase maintains ionotropic receptor expression for cool temperature sensing and avoidance in<i>Drosophila</i> Open
Sensory inputs of temperature dynamics in the environment are essential for appropriate physiological outputs. The responsiveness of sensory neurons is maintained by functional thermosensor expression. However, the mechanism by which their…
View article: Functional relationship between peripheral thermosensation and behavioral thermoregulation
Functional relationship between peripheral thermosensation and behavioral thermoregulation Open
Thermoregulation is a fundamental mechanism for maintaining homeostasis in living organisms because temperature affects essentially all biochemical and physiological processes. Effector responses to internal and external temperature cues a…
View article: Involvement of TRPV4 in temperature-dependent perspiration in mice
Involvement of TRPV4 in temperature-dependent perspiration in mice Open
Reports indicate that an interaction between TRPV4 and anoctamin 1 (ANO1) could be widely involved in water efflux of exocrine glands, suggesting that the interaction could play a role in perspiration. In secretory cells of sweat glands pr…
View article: Author response: Involvement of TRPV4 in temperature-dependent perspiration in mice
Author response: Involvement of TRPV4 in temperature-dependent perspiration in mice Open
View article: Joint Public Review: Involvement of TRPV4 in temperature-dependent perspiration in mice
Joint Public Review: Involvement of TRPV4 in temperature-dependent perspiration in mice Open
Reports indicate that an interaction between TRPV4 and anoctamin 1 could be widely involved in water efflux of exocrine glands, suggesting that the interaction could play a role in perspiration. In secretory cells of sweat glands present i…
View article: Involvement of TRPV4 in temperature-dependent perspiration in mice
Involvement of TRPV4 in temperature-dependent perspiration in mice Open
Reports indicate that an interaction between TRPV4 and anoctamin 1 could be widely involved in water efflux of exocrine glands, suggesting that the interaction could play a role in perspiration. In secretory cells of sweat glands present i…
View article: Author response: Involvement of TRPV4 in temperature-dependent perspiration in mice
Author response: Involvement of TRPV4 in temperature-dependent perspiration in mice Open
Reports indicate that an interaction between TRPV4 and anoctamin 1 could be widely involved in water efflux of exocrine glands, suggesting that the interaction could play a role in perspiration. In secretory cells of sweat glands present i…
View article: Interaction between TRP channels and anoctamins
Interaction between TRP channels and anoctamins Open
Anoctamin 1 (ANO1) binds to transient receptor potential (TRP) channels (protein-protein interaction) and then is activated by TRP channels (functional interaction). TRP channels are non-selective cation channels that are expressed through…
View article: Structural Pharmacology of TRPV4 Antagonists
Structural Pharmacology of TRPV4 Antagonists Open
The nonselective calcium‐permeable Transient Receptor Potential Cation Channel Subfamily V Member4 (TRPV4) channel regulates various physiological activities. Dysfunction of TRPV4 is linked to many severe diseases, including edema, pain, g…
View article: Integrin α5 regulates motility of human monocyte‐derived Langerhans cells during immune response
Integrin α5 regulates motility of human monocyte‐derived Langerhans cells during immune response Open
Langerhans cells (LCs) are mainly present in the epidermis and mucosa, and have important roles during skin infection. Migration of LCs to lymph nodes is essential for antigen presentation. However, due to the difficulties in isolating and…
View article: G protein-coupled receptor-based thermosensation determines temperature acclimatization of Caenorhabditis elegans
G protein-coupled receptor-based thermosensation determines temperature acclimatization of Caenorhabditis elegans Open
Animals must sense and acclimatize to environmental temperatures for survival, yet their thermosensing mechanisms other than transient receptor potential (TRP) channels remain poorly understood. We identify a trimeric G protein-coupled rec…
View article: Phosphorylated TRPV1 and ANO1 ⁄ TMEM16A interaction induced by low concentration of capsaicin or innocuous heat stimulation
Phosphorylated TRPV1 and ANO1 ⁄ TMEM16A interaction induced by low concentration of capsaicin or innocuous heat stimulation Open
Transient receptor potential vanilloid 1 (TRPV1), a capsaicin receptor, and anoctamin 1 (ANO1, also called TMEM16A), a calcium–activated chloride channel, are major ion channels involved in pain sensation in the peripheral nervous system.…
View article: Involvement of TRPV4 in temperature-dependent perspiration in mice
Involvement of TRPV4 in temperature-dependent perspiration in mice Open
Reports indicate that an interaction between TRPV4 and anoctamin 1 (ANO1) could be widely involved in water efflux of exocrine glands, suggesting that the interaction could play a role in perspiration. In secretory cells of sweat glands pr…
View article: Involvement of TRPV4 in temperature-dependent perspiration in mice
Involvement of TRPV4 in temperature-dependent perspiration in mice Open
Reports indicate that an interaction between TRPV4 and anoctamin 1 could be widely involved in water efflux of exocrine glands, suggesting that the interaction could play a role in perspiration. In secretory cells of sweat glands present i…
View article: Thermal gradient ring for analysis of temperature-dependent behaviors involving TRP channels in mice
Thermal gradient ring for analysis of temperature-dependent behaviors involving TRP channels in mice Open
View article: Propofol Reduces Human Trpa1 Activity in a Warm Environment
Propofol Reduces Human Trpa1 Activity in a Warm Environment Open
View article: Avoidance of thiazoline compound depends on multiple sensory pathways mediated by TrpA1 and ORs in Drosophila
Avoidance of thiazoline compound depends on multiple sensory pathways mediated by TrpA1 and ORs in Drosophila Open
Transient receptor potential (TRP) channels are primary sensory molecules in animals and are involved in detecting a diverse range of physical and chemical cues in the environments. Considering the crucial role of TRPA1 channels in nocifen…