Hidetoshi Eguchi
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View article: Prognostic Impact of Immunoscore in Pathological Stage <scp>III</scp> Differentiated Gastric Cancer: A Multicenter Cohort Study Including <scp>PD</scp> ‐ <scp>L1</scp> / <scp>PD</scp> ‐ <scp>L2</scp> Expression Analysis
Prognostic Impact of Immunoscore in Pathological Stage <span>III</span> Differentiated Gastric Cancer: A Multicenter Cohort Study Including <span>PD</span> ‐ <span>L1</span> / <span>PD</span> ‐ <span>L2</span> Expression Analysis Open
Background The clinical use of the tumor microenvironment as a biomarker remains difficult in gastric cancer (GC). This multicenter, retrospective cohort study assessed the prognostic ability of the Immunoscore (IS) and the expression of p…
View article: Bacteria-derived DNA in serum extracellular vesicles as a biomarker for gastric cancer
Bacteria-derived DNA in serum extracellular vesicles as a biomarker for gastric cancer Open
View article: Clinical Significance of Copper Chaperone for Superoxide Dismutase in Colorectal Cancer
Clinical Significance of Copper Chaperone for Superoxide Dismutase in Colorectal Cancer Open
Background Targeting Cu transport proteins is an innovative therapeutic approach for combating cancer. However, the mechanisms underlying the malignant potential of Cu transport proteins remain largely unknown. To address this issue, we fo…
View article: Pre‐Operative Resistance Training and Amino Acid Supplementation in Frail Patients With Gastrointestinal Cancer: A Randomized Clinical Trial
Pre‐Operative Resistance Training and Amino Acid Supplementation in Frail Patients With Gastrointestinal Cancer: A Randomized Clinical Trial Open
Aim To investigate the impact of preoperative exercise and nutritional interventions on postoperative complications, physical function, and activities of daily living ( ADL ) 1 year postoperatively in frail older patients with gastrointest…
View article: Manual repositioning of the small bowel and omentum prevents early postoperative small bowel obstruction after laparoscopic colorectal surgery: a propensity score-matched study
Manual repositioning of the small bowel and omentum prevents early postoperative small bowel obstruction after laparoscopic colorectal surgery: a propensity score-matched study Open
Background Early postoperative small bowel obstruction (EPSBO) is a common complication after colorectal cancer surgery, even with minimally invasive techniques. While anti-adhesion agents are used, effective intraoperative strategies rema…
View article: Epigenetic Regulation of <scp>G6PD</scp> Drives Metabolic Reprogramming in Intrahepatic Cholangiocarcinoma
Epigenetic Regulation of <span>G6PD</span> Drives Metabolic Reprogramming in Intrahepatic Cholangiocarcinoma Open
Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive malignancy with poor prognosis and significant molecular heterogeneity. This study investigates the role of tumor‐specific enhancers in metabolic reprogramming, focusing on gluco…
View article: Saireito (TJ-114) for Preventing High-Output Syndrome After Temporary Ileostomy in Rectal Cancer Surgery
Saireito (TJ-114) for Preventing High-Output Syndrome After Temporary Ileostomy in Rectal Cancer Surgery Open
View article: Efficacy and safety of anamorelin for cancer cachexia in patients with unresectable or recurrent gastric cancer: a multicentre, open-label, randomised controlled trial
Efficacy and safety of anamorelin for cancer cachexia in patients with unresectable or recurrent gastric cancer: a multicentre, open-label, randomised controlled trial Open
Ono Pharmaceutical Co., Ltd.
View article: Flexible suction–coagulation probe restores dexterity in robot-assisted surgery: bench-to-bedside evaluation
Flexible suction–coagulation probe restores dexterity in robot-assisted surgery: bench-to-bedside evaluation Open
Objective Rigid suction–coagulation probes constrain the wrist-like articulation that is central to robotic surgery. We therefore designed a 5-mm single-use flexible suction ball coagulator (flex-SBC) with a modified core design to restore…
View article: Targeting yes-associated protein to overcome imatinib resistance in gastrointestinal stromal tumor drug-tolerant persister cells
Targeting yes-associated protein to overcome imatinib resistance in gastrointestinal stromal tumor drug-tolerant persister cells Open
View article: Impact of PD-1+Tim-3+CD8+ T cells in pretreatment tumors on chemotherapy responses in esophageal cancer
Impact of PD-1+Tim-3+CD8+ T cells in pretreatment tumors on chemotherapy responses in esophageal cancer Open
While chemotherapy has traditionally been recognized for its direct cytotoxic effects on cancer cells, increasing attention has been directed towards its capability to modulate tumor immune mechanisms. However, the majority of studies have…
View article: Tumor Endothelial Cells Induce <scp>M2</scp> Macrophage Polarization via <scp>IL</scp> ‐4, Enhancing Tumor Growth in Hepatocellular Carcinoma
Tumor Endothelial Cells Induce <span>M2</span> Macrophage Polarization via <span>IL</span> ‐4, Enhancing Tumor Growth in Hepatocellular Carcinoma Open
Tumor‐associated macrophages (TAMs) and tumor endothelial cells (TECs) are important components in tumor microenvironments. This study examined the interaction between TECs and TAMs in hepatocellular carcinoma (HCC). The aim of this study …
View article: Outcome of Conversion Surgery After Induction Therapy for Esophageal Cancer with Synchronous Para-Aortic Lymph Node Metastasis: A Multi-institutional Retrospective Study
Outcome of Conversion Surgery After Induction Therapy for Esophageal Cancer with Synchronous Para-Aortic Lymph Node Metastasis: A Multi-institutional Retrospective Study Open
Background Systemic chemotherapy is the standard treatment for esophageal cancer with synchronous distant metastasis including para-aortic lymph node (PALN) metastasis. The significance of conversion surgery for esophageal cancer with sync…
View article: Bacteria-derived DNA in serum extracellular vesicles as a biomarker for gastric cancer
Bacteria-derived DNA in serum extracellular vesicles as a biomarker for gastric cancer Open
Bacterial flora is present in various parts of the human body, and recent studies have detected bacterial 16S rRNA genes in the bloodstream. Distinct blood microbiomes have been identified in various diseases, including cancer, and are tho…
View article: The Role of Mitochondrial DNA in Modulating Chemoresistance in Esophageal Cancer: Mechanistic Insights and Therapeutic Potential
The Role of Mitochondrial DNA in Modulating Chemoresistance in Esophageal Cancer: Mechanistic Insights and Therapeutic Potential Open
Chemotherapy remains a cornerstone in the treatment of esophageal cancer (EC), yet chemoresistance remains a critical challenge, leading to poor outcomes and limited therapeutic success. Mitochondrial DNA (mtDNA) has emerged as a pivotal p…
View article: Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution Open
View article: Intraoperative visualization of lymphatic flow along the ileocolic artery using ICG fluorescence imaging and its implications for right-sided colon cancer surgery
Intraoperative visualization of lymphatic flow along the ileocolic artery using ICG fluorescence imaging and its implications for right-sided colon cancer surgery Open
Background In colorectal cancer surgery, especially for right-sided colon cancer, understanding the anatomical course of lymphatic flow along the ileocolic artery (ICA) is crucial for safe and oncologically adequate mesenteric dissection. …
View article: Clinical impact of primary and secondary KIT mutations on the efficacy of molecular-targeted therapies in gastrointestinal stromal tumors
Clinical impact of primary and secondary KIT mutations on the efficacy of molecular-targeted therapies in gastrointestinal stromal tumors Open
View article: The effect of neoadjuvant chemoradiation therapy in resectable pancreatic cancer was independent of intratumoral vascularization
The effect of neoadjuvant chemoradiation therapy in resectable pancreatic cancer was independent of intratumoral vascularization Open
The histopathological efficacy of NACRT for resectable PC did not differ significantly on the basis of enhancement pattern observed on CH-EUS. NACRT may provide additional therapeutic benefit independent of blood flow considerations.
View article: Prognostic Impact of Pancreatic Body/Tail Cancer Involving the Portal Vein: A Project Study of the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery
Prognostic Impact of Pancreatic Body/Tail Cancer Involving the Portal Vein: A Project Study of the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery Open
Background Although portal vein (PV) contact ≤ 180° in pancreatic body/tail ductal adenocarcinoma (PbtCa) is a criterion for resectable, adequate evidence has not been established yet. Methods This retrospective study analyzed 1693 patient…
View article: Intraoperative corticosteroid administration for resectable gastric cancer: a multicenter, randomized, open-label, phase II/III study
Intraoperative corticosteroid administration for resectable gastric cancer: a multicenter, randomized, open-label, phase II/III study Open
View article: Effect of anamorelin on body weight in patients with gastric cancer-associated cachexia: an observational study
Effect of anamorelin on body weight in patients with gastric cancer-associated cachexia: an observational study Open
Background In 2021, anamorelin, a ghrelin receptor agonist, was approved in Japan for cancer cachexia in select cancers, including gastric cancer. However, evidence regarding its efficacy and predictive factors in patients with gastric can…
View article: Enrichment of ornithine decarboxylase degron transduced colorectal cancer cells for extended application of cancer stem cell models
Enrichment of ornithine decarboxylase degron transduced colorectal cancer cells for extended application of cancer stem cell models Open
View article: Discrepancy Between Radiographic and Pathological Response Assessment in Neoadjuvant Treatment for Pancreatic Cancer: A Comparison Between Neoadjuvant Chemotherapy and Neoadjuvant Chemoradiotherapy
Discrepancy Between Radiographic and Pathological Response Assessment in Neoadjuvant Treatment for Pancreatic Cancer: A Comparison Between Neoadjuvant Chemotherapy and Neoadjuvant Chemoradiotherapy Open
Aim Appropriate reassessment of treatment response plays a crucial role in identifying optimal candidates for resection in neoadjuvant treatment (NAT) strategy for pancreatic cancer (PC); however, radiological evaluations are associated wi…
View article: Conditional Survival for Pancreas Graft and Its Associated Factors After Pancreas Transplantation
Conditional Survival for Pancreas Graft and Its Associated Factors After Pancreas Transplantation Open
Aim Traditional actuarial graft survival estimates are useful in pancreas transplantation (PTx) cases. From the perspective of patients, however, a more accurate estimate is necessary to predict long‐term prognosis with consideration of th…
View article: Dynamic contrast-enhanced CT-derived extracellular volume fraction for predicting postoperative oncologic outcomes in pancreatic ductal adenocarcinoma
Dynamic contrast-enhanced CT-derived extracellular volume fraction for predicting postoperative oncologic outcomes in pancreatic ductal adenocarcinoma Open
The fECV of noncancerous pancreatic parenchyma from CE-CT was a significant predictor of survival outcomes in PDAC.
View article: Development of novel thoracic retractor for resuscitative thoracotomy
Development of novel thoracic retractor for resuscitative thoracotomy Open
View article: Significance of Neoadjuvant S‐1‐Based Chemotherapy for Older Patients With Locally Advanced Gastric Cancer
Significance of Neoadjuvant S‐1‐Based Chemotherapy for Older Patients With Locally Advanced Gastric Cancer Open
Background Neoadjuvant chemotherapy (NAC) has been extensively developed for locally advanced gastric cancer (GC). In Asia, S‐1‐based regimens, such as docetaxel, oxaliplatin, and S‐1 (DOS) and S‐1 and oxaliplatin (SOX), are expected to be…
View article: Role of the Circadian Clock Gene<i>DEC1</i>in Chemosensitivity and Apoptosis in Colorectal Cancer
Role of the Circadian Clock Gene<i>DEC1</i>in Chemosensitivity and Apoptosis in Colorectal Cancer Open
DEC1 expression is related to the circadian rhythm in colorectal cancer cells, and several other genes contribute to this relationship. Overall, DEC1 may function beyond circadian rhythm regulation, potentially affecting the development an…
View article: Effects of Saireito (TJ-114), a traditional Japanese herbal medicine, on high-output syndrome after the creation of a temporary ileostomy in rectal cancer surgery
Effects of Saireito (TJ-114), a traditional Japanese herbal medicine, on high-output syndrome after the creation of a temporary ileostomy in rectal cancer surgery Open
Purpose: In rectal cancer surgery, a temporary ileostomy is often created to prevent clinical anastomotic leakage. However, high-output syndrome (HOS) frequently arises as a postoperative complication. We aimed to investigate the preventiv…