Makoto Sonobe
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View article: Management and survival outcomes of patients with postoperative recurrence of non-small cell lung cancer at isolated ipsilateral hilar or mediastinal lymph node
Management and survival outcomes of patients with postoperative recurrence of non-small cell lung cancer at isolated ipsilateral hilar or mediastinal lymph node Open
Our data suggest that various treatments are administered for postoperative recurrence at isolated ipsilateral hilar or mediastinal LN, differing from current guideline recommendations, which is associated with acceptable survival outcomes…
View article: Left Upper Lobectomy for Pulmonary Vein Occlusion After Catheter Ablation for Atrial Fibrillation
Left Upper Lobectomy for Pulmonary Vein Occlusion After Catheter Ablation for Atrial Fibrillation Open
A 64-year-old man complained of recurrent bloody sputum 6 months after catheter ablation for atrial fibrillation. Contrast-enhanced chest computed tomography revealed left upper pulmonary vein occlusion. Due to challenges in revascularizat…
View article: Characteristics and outcomes of salvage surgery after immune checkpoint inhibitor therapy for initially unresectable non-small cell lung cancer
Characteristics and outcomes of salvage surgery after immune checkpoint inhibitor therapy for initially unresectable non-small cell lung cancer Open
Salvage surgery after ICIs may be associated with low perioperative morbidity and acceptable long-term outcomes in selected patients. Salvage resection of primary lesions may be associated with more favorable PFS than of metastatic lesions.
View article: Case Series of Tracheal Cancer Subsequent to Primary Lung Cancer Surgery
Case Series of Tracheal Cancer Subsequent to Primary Lung Cancer Surgery Open
背景.気管内悪性腫瘍は非常にまれな腫瘍であり,発見及び診断に難渋することが多い.今回,原発性肺癌手術後の経過観察中に気管癌を発症した症例を経験したので報告する.症例1.81歳,女性.右下葉肺扁平上皮癌に対して右中下葉切除及びリンパ節郭清を施行した.術後3年6ヶ月のCTで気管壁の肥厚を認めた.気管支鏡下の擦過細胞診で扁平上皮癌と診断した.症例2.81歳,男性.右下葉肺扁平上皮癌に対して右肺下葉切除及びリンパ節郭清を施行した.術後2年6ヶ月に撮影したPET-CTで気管周囲の異常…
View article: Adjuvant Chemotherapy After Neoadjuvant Therapy and Surgery for Non-Small Cell Lung Cancer
Adjuvant Chemotherapy After Neoadjuvant Therapy and Surgery for Non-Small Cell Lung Cancer Open
Adjuvant chemotherapy was not associated with favorable survival outcomes in patients treated with surgery after neoadjuvant therapy for locally advanced NSCLC.
View article: Gingival Metastasis After Surgery for Early-Stage Lung Adenocarcinoma
Gingival Metastasis After Surgery for Early-Stage Lung Adenocarcinoma Open
A 69-year-old male patient underwent a left upper lung lobectomy and nodal dissection for left upper lung adenocarcinoma. His pathologic stage was pT2aN0M0, stage 1B. He received oral tegafur/uracil for adjuvant chemotherapy and visited ou…
View article: Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses
Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses Open
View article: Lymphedema After Salvage Surgery for Thymic Carcinoma
Lymphedema After Salvage Surgery for Thymic Carcinoma Open
View article: COVID-19 Vaccine-related Lymphadenopathy in Lung Cancer Patients: a Presentation of Three Cases with Suggestions for Management
COVID-19 Vaccine-related Lymphadenopathy in Lung Cancer Patients: a Presentation of Three Cases with Suggestions for Management Open
Background. Axillary lymphadenopathy after COVID-19 vaccination have been frequently reported in the medical literature. This benign reaction can be confused with metastases of thoracic malignancies. We experienced three lung cancer cases …
View article: Epidermal growth factor receptor tyrosine kinase inhibitors as first-line treatment for postoperative recurrent <i>EGFR</i>-mutated lung adenocarcinoma: a multi-institutional retrospective study
Epidermal growth factor receptor tyrosine kinase inhibitors as first-line treatment for postoperative recurrent <i>EGFR</i>-mutated lung adenocarcinoma: a multi-institutional retrospective study Open
OBJECTIVES The aim of this study was to analyse the long-term survival outcomes and prognostic factors of patients receiving epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) as first-line treatment for postoperative …
View article: Pure red cell aplasia with thymoma maintaining remission without treatment after cyclosporine therapy and thymomectomy: Report of a case
Pure red cell aplasia with thymoma maintaining remission without treatment after cyclosporine therapy and thymomectomy: Report of a case Open
62歳，男性．呼吸困難感のため救急外来を受診され，ヘモグロビンが4.1 g/dLの高度貧血で，骨髄検査では赤芽球のみが低形成，胸部CTでは右肺上葉の結節影と前縦隔の腫瘤影を認めた．胸腺腫を合併した赤芽球癆と診断し，胸腔鏡下胸腺腫摘除術，右肺部分切除術を施行した．病理組織検査では正岡分類I期，type AB胸腺腫および肺過誤腫であった．術後8日よりシクロスポリンを導入した．寛解を得てシクロスポリンを緩徐に減量し，術後1年4ヵ月に投与を終了した．術後5年を経過し，赤芽球癆は寛解…
View article: Surgical management of hemothorax after radiofrequency ablation for liver tumor
Surgical management of hemothorax after radiofrequency ablation for liver tumor Open
【はじめに】肝腫瘍に対するラジオ波焼灼術は安全性が高く，大量血胸の発症は稀である．【対象】2006年から2015年までに当院で施行したラジオ波焼灼術の3,228例のうち，血胸を合併し手術を要した5例について検討した．【結果】全例が肝硬変および肝細胞癌を罹患していた．術前に1例が経カテーテル的肋間動脈塞栓術を施行され，2例が胸腔穿刺を行われた．アプローチは開胸が1例，小開胸が3例，完全鏡視下が1例であった．術中に1例で活動性出血を認め，自然止血していた4例中3例で出血部位が推…
View article: Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301
Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301 Open
Background The aim of this multicenter, randomized phase II study was to analyze the feasibility and safety of alternate-day S-1, an oral fluoropyrimidine, for adjuvant chemotherapy in patients with completely resected pathological stage I…
View article: Validation Study of the International Association for the Study of Lung Cancer Histologic Grading System of Invasive Lung Adenocarcinoma
Validation Study of the International Association for the Study of Lung Cancer Histologic Grading System of Invasive Lung Adenocarcinoma Open
We reported that the IASLC system for invasive lung ADC has prognostic significance by evaluating a large Japanese cohort. We believe that the IASLC grading system will provide physicians with better information for postsurgery treatment.
View article: Lymph node dissection in thymic carcinomas and neuroendocrine carcinomas
Lymph node dissection in thymic carcinomas and neuroendocrine carcinomas Open
OBJECTIVES Although lymph node (LN) metastases are not uncommon in thymic carcinomas, preoperative LN evaluation, intraoperative lymph node dissection (LND) and postoperative outcomes remain unknown. The aim of this study was to elucidate …
View article: Prognostic significance of cribriform adenocarcinoma of the lung: validation analysis of 1,057 Japanese patients with resected lung adenocarcinoma and a review of the literature
Prognostic significance of cribriform adenocarcinoma of the lung: validation analysis of 1,057 Japanese patients with resected lung adenocarcinoma and a review of the literature Open
Cribri-ADC is associated with a higher risk of recurrence; however, most patients can be successfully treated with TKIs.
View article: Additional file 4 of Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301
Additional file 4 of Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301 Open
Additional file 4. Online Resource 4. Method for dose reduction of S-1.
View article: Additional file 6 of Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301
Additional file 6 of Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301 Open
Additional file 6. Online resourse 6. Follow-up assessment.
View article: Additional file 3 of Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301
Additional file 3 of Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301 Open
Additional file 3. Online Resource 3. Criteria for dose reduction.
View article: Additional file 2 of Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301
Additional file 2 of Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301 Open
Additional file 2. Online Resource 2. The criteria for discontinuation and restant of S-1 administration.
View article: VATS right upper lobectomy for primary lung cancer after esophagectomy: Report of a case
VATS right upper lobectomy for primary lung cancer after esophagectomy: Report of a case Open
症例は75歳，男性．胸部下部食道癌に対して胸腔鏡下食道亜全摘術，後縦隔経路胃管再建，2領域リンパ節郭清を施行された．食道癌術後1年3ヵ月，胸部CTで右上葉陰影の増大と右肺門リンパ節の腫大を指摘され，原発性肺癌（cT1bN1M0，StageIIB）を疑い，手術の方針とした．胸腔内は，再建胃管およびその周囲の縦隔部分が肺と強固に癒着していた．再建胃管周囲を可能な限り愛護的に剥離を行い，上葉切除および上縦隔郭清を完遂できた．食道癌根治術後の右上葉肺癌手術における術前および術中の注…
View article: Large nest micropapillary pattern of lung adenocarcinoma has poorer prognosis than typical floret pattern: analysis of 1,062 resected tumors
Large nest micropapillary pattern of lung adenocarcinoma has poorer prognosis than typical floret pattern: analysis of 1,062 resected tumors Open
Large nest MP-p should be included in the original MP-p and recorded separately.
View article: Tranilast Inhibits TGF-β1–induced Epithelial-mesenchymal Transition and Invasion/Metastasis <i>via</i> the Suppression of Smad4 in Human Lung Cancer Cell Lines
Tranilast Inhibits TGF-β1–induced Epithelial-mesenchymal Transition and Invasion/Metastasis <i>via</i> the Suppression of Smad4 in Human Lung Cancer Cell Lines Open
Tranilast inhibited TGF-β1-induced EMT and cellular invasion/metastasis by suppressing Smad4 expression in cancer cells.
View article: Discohesive growth pattern (Disco-p) as an unfavorable prognostic factor in lung adenocarcinoma: an analysis of 1062 Japanese patients with resected lung adenocarcinoma
Discohesive growth pattern (Disco-p) as an unfavorable prognostic factor in lung adenocarcinoma: an analysis of 1062 Japanese patients with resected lung adenocarcinoma Open
View article: A case report: primary thymic adenocarcinoma with enteric differentiation
A case report: primary thymic adenocarcinoma with enteric differentiation Open
View article: Videothoracoscopic closure of pleuroperitoneal communication with hepatic hydrothorax preoperatively detected using contrast-enhanced ultrasonography
Videothoracoscopic closure of pleuroperitoneal communication with hepatic hydrothorax preoperatively detected using contrast-enhanced ultrasonography Open
肝性胸水は肝硬変に伴う漏出性胸水の貯留であり，横隔膜の瘻孔により腹腔と胸腔とが交通し，腹水が胸腔内に流入するということが原因の1つとして知られている．我々は難治性の肝性胸水に対し，超音波造影剤であるペルフルブタンを腹腔内に注入し造影超音波検査を行うことで横隔膜の瘻孔を同定し，胸腔鏡にポリグルコール酸シート付きの自動縫合器を用いて瘻孔を閉鎖した例を経験した．造影超音波検査は簡便であり，手術前に瘻孔の局在を確認できるので有用であると考えられた．
View article: Prognostic factors related to postoperative survival in the newly classified clinical T4 lung cancer
Prognostic factors related to postoperative survival in the newly classified clinical T4 lung cancer Open
OBJECTIVES T4 lung cancer has become a more heterogeneous group since the 8th edition of tumour, node, metastasis classification. The aim of this study was to identify predictive factors related to post-surgical survival in patients with c…
View article: Salvage Surgery After Chemotherapy or Chemoradiotherapy for Initially Unresectable Lung Carcinoma
Salvage Surgery After Chemotherapy or Chemoradiotherapy for Initially Unresectable Lung Carcinoma Open
View article: Statins may have double-edged effects in patients with lung adenocarcinoma after lung resection
Statins may have double-edged effects in patients with lung adenocarcinoma after lung resection Open
Shigeto Nishikawa,1 Toshi Menju,1 Koji Takahashi,1 Ryo Miyata,1 Toyofumi Fengshi Chen-Yoshikawa,1 Makoto Sonobe,1 Akihiko Yoshizawa,2 Hisataka Sabe,3 Tosiya Sato,4 Hiroshi Date11Department of Thoracic Surgery, Graduate School of Medicine, …
View article: Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma
Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma Open
Current clinically approved biomarkers for the PD-1 blockade cancer immunotherapy are based entirely on the properties of tumour cells. With increasing awareness of clinical responses, more precise biomarkers for the efficacy are required …