Mala Ananth
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View article: A central role for acetylcholine in entorhinal cortex function and dysfunction with age in humans and mice
A central role for acetylcholine in entorhinal cortex function and dysfunction with age in humans and mice Open
Structural and functional changes in the entorhinal cortex (EC) are among the earliest signs of cognitive aging. Here, we ask whether a compromised cholinergic system influences early EC impairments and plays a primary role in EC cognition…
View article: Loss of cholinergic input to the entorhinal cortex is an early indicator of cognitive impairment in natural aging of humans and mice
Loss of cholinergic input to the entorhinal cortex is an early indicator of cognitive impairment in natural aging of humans and mice Open
In a series of translational experiments using fully quantitative positron emission tomography (PET) imaging with a new tracer specific for the vesicular acetylcholine transporter ([ 18 F]VAT) in vivo in humans, and genetically targeted ch…
View article: Functionally refined encoding of threat memory by distinct populations of basal forebrain cholinergic projection neurons
Functionally refined encoding of threat memory by distinct populations of basal forebrain cholinergic projection neurons Open
Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/SI p ) comprise the major source of cholinergic input to the basolateral amygdala (BLA). Using a genetically encoded acetylcholine (ACh) sensor in mice…
View article: Functionally refined encoding of threat memory by distinct populations of basal forebrain cholinergic projection neurons.
Functionally refined encoding of threat memory by distinct populations of basal forebrain cholinergic projection neurons. Open
Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/SI p ) comprise the major source of cholinergic input to the basolateral amygdala (BLA). Using a genetically-encoded acetylcholine (ACh) sensor in mice…
View article: Loss of septal cholinergic input to lateral entorhinal cortex is an early indicator of cognitive impairment
Loss of septal cholinergic input to lateral entorhinal cortex is an early indicator of cognitive impairment Open
Although alterations to central cholinergic signaling are characteristic of late-stage cognitive deficits, the early temporal profile of these alterations and their relationship to more subtle changes in cognition are less clear. In a seri…
View article: Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli
Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli Open
The ventral pallidum (VP) mediates motivated behaviors largely via the action of VP GABA and glutamatergic neurons. In addition to these neuronal subtypes, there is a population of cholinergic projection neurons in the VP, whose functional…
View article: <i>In vivo</i> serotonin 1A receptor hippocampal binding potential in depression and reported childhood adversity
<i>In vivo</i> serotonin 1A receptor hippocampal binding potential in depression and reported childhood adversity Open
Background Reported childhood adversity (CA) is associated with development of depression in adulthood and predicts a more severe course of illness. Although elevated serotonin 1A receptor (5-HT 1A R) binding potential, especially in the r…
View article: NeuroConstruct: 3D Reconstruction and Visualization of Neurites in Optical Microscopy Brain Images
NeuroConstruct: 3D Reconstruction and Visualization of Neurites in Optical Microscopy Brain Images Open
We introduce NeuroConstruct, a novel end-to-end application for the segmentation, registration, and visualization of brain volumes imaged using wide-field microscopy. NeuroConstruct offers a Segmentation Toolbox with various annotation hel…
View article: Basal forebrain cholinergic neurons are part of the threat memory engram
Basal forebrain cholinergic neurons are part of the threat memory engram Open
Summary Although the engagement of cholinergic signaling in threat memory is well established (Knox, 2016a), our finding that specific cholinergic neurons are requisite partners in a threat memory engram is likely to surprise many. Neurons…
View article: The functional networks of a novel environment: Neural activity mapping in awake unrestrained rats using positron emission tomography
The functional networks of a novel environment: Neural activity mapping in awake unrestrained rats using positron emission tomography Open
Introduction Novel environment stimulation is thought to have an important role in cognitive development and has been shown to encourage exploratory behavior in rats. However, psychopathology or perceived danger or stress can impede this e…
View article: Chronic Methamphetamine Effects on Brain Structure and Function in Rats
Chronic Methamphetamine Effects on Brain Structure and Function in Rats Open
Methamphetamine (MA) addiction is a growing epidemic worldwide. Chronic MA use has been shown to lead to neurotoxicity in rodents and humans. Magnetic resonance imaging (MRI) studies in MA users have shown enlarged striatal volumes and pos…
View article: Specific Basal Forebrain–Cortical Cholinergic Circuits Coordinate Cognitive Operations
Specific Basal Forebrain–Cortical Cholinergic Circuits Coordinate Cognitive Operations Open
Based on recent molecular genetics, as well as functional and quantitative anatomical studies, the basal forebrain (BF) cholinergic projections, once viewed as a diffuse system, are emerging as being remarkably specific in connectivity. Ac…
View article: Decreased Pretreatment Amygdalae Serotonin Transporter Binding in Unipolar Depression Remitters: A Prospective PET Study
Decreased Pretreatment Amygdalae Serotonin Transporter Binding in Unipolar Depression Remitters: A Prospective PET Study Open
Major depressive disorder (MDD) is a debilitating condition that affects over 14 million Americans. Remission occurs only in a minority of individuals after first-line antidepressant treatment (∼35%); predictors of treatment outcome are th…
View article: Electrophysiological properties of basal forebrain cholinergic neurons identified by genetic and optogenetic tagging
Electrophysiological properties of basal forebrain cholinergic neurons identified by genetic and optogenetic tagging Open
Recent developments in the generation of neuronal population‐specific, genetically modified mouse lines have allowed precise identification and selective stimulation of cholinergic neurons in vivo . Although considerably less laborious tha…
View article: Correction: Chronic Methamphetamine Effects on Brain Structure and Function in Rats
Correction: Chronic Methamphetamine Effects on Brain Structure and Function in Rats Open
[This corrects the article DOI: 10.1371/journal.pone.0155457.].
View article: Chronic Methamphetamine Effects on Brain Structure and Function in Rats
Chronic Methamphetamine Effects on Brain Structure and Function in Rats Open
Methamphetamine (MA) addiction is a growing epidemic worldwide. Chronic MA use has been shown to lead to neurotoxicity in rodents and humans. Magnetic resonance imaging (MRI) studies in MA users have shown enlarged striatal volumes and pos…