Mala Chakraborty
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View article: 804 4–1BBL/4–1BB interaction is critical for EBV-transformed B cells to induce NK cell proliferation
804 4–1BBL/4–1BB interaction is critical for EBV-transformed B cells to induce NK cell proliferation Open
View article: Spleen tyrosine kinase inhibition restores neutrophil homeostasis in COVID-19
Spleen tyrosine kinase inhibition restores neutrophil homeostasis in COVID-19 Open
Spleen tyrosine kinase (SYK) is a novel therapeutic target that inhibits neutrophil and macrophage activation in coronavirus disease 2019 (COVID-19). Fostamatinib, a SYK inhibitor, was studied in a phase 2 placebo-controlled randomized cli…
View article: Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19
Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19 Open
Spleen tyrosine kinase (SYK) is a previously unidentified therapeutic target that inhibits neutrophil and macrophage activation in coronavirus disease 2019 (COVID-19). Fostamatinib, a SYK inhibitor, was studied in a phase 2 placebo-control…
View article: Expanded NK cells used for adoptive cell therapy maintain diverse clonality and contain long-lived memory-like NK cell populations
Expanded NK cells used for adoptive cell therapy maintain diverse clonality and contain long-lived memory-like NK cell populations Open
View article: High-affinity CD16 integration into a CRISPR/Cas9-edited CD38 locus augments CD38-directed antitumor activity of primary human natural killer cells
High-affinity CD16 integration into a CRISPR/Cas9-edited CD38 locus augments CD38-directed antitumor activity of primary human natural killer cells Open
Background Adoptive transfer of natural killer (NK) cells with augmented antibody-dependent cellular cytotoxicity (ADCC) capabilities and resistance to CD38 targeting has the potential to enhance the clinical anti-myeloma activity of darat…
View article: 170 Novel gene editing approach to enhance CD38-directed antitumor activity of primary human natural killer cells
170 Novel gene editing approach to enhance CD38-directed antitumor activity of primary human natural killer cells Open
Background Natural killer (NK) cells play an important role in the antitumor responses of therapeutic monoclonal antibodies (mAbs) by mediating antibody-dependent cellular cytotoxicity (ADCC). ADCC occurs when tumor-ligated mAbs trigger NK…
View article: Fostamatinib for the Treatment of Hospitalized Adults With Coronavirus Disease 2019: A Randomized Trial
Fostamatinib for the Treatment of Hospitalized Adults With Coronavirus Disease 2019: A Randomized Trial Open
Background Coronavirus disease 2019 (COVID-19) requiring hospitalization is characterized by robust antibody production, dysregulated immune response, and immunothrombosis. Fostamatinib is a novel spleen tyrosine kinase inhibitor that we h…
View article: Systematic improvements in lentiviral transduction of primary human natural killer cells undergoing ex vivo expansion
Systematic improvements in lentiviral transduction of primary human natural killer cells undergoing ex vivo expansion Open
View article: Augmentation of NK Cell Proliferation and Anti-tumor Immunity by Transgenic Expression of Receptors for EPO or TPO
Augmentation of NK Cell Proliferation and Anti-tumor Immunity by Transgenic Expression of Receptors for EPO or TPO Open
View article: Drug‐induced allergic hepatitis develops in mice when myeloid‐derived suppressor cells are depleted prior to halothane treatment
Drug‐induced allergic hepatitis develops in mice when myeloid‐derived suppressor cells are depleted prior to halothane treatment Open
Clinical evidence suggests that many cases of serious idiosyncratic drug‐induced liver injury are mediated by the adaptive immune system in response to hepatic drug‐protein adducts, also referred to as “drug‐induced allergic hepatitis”; bu…